NUCLEAR MAGNETIC RESONANCE (NMR) FINGERPRINTING
First Claim
1. A method, comprising:
- controlling a nuclear magnetic resonance (NMR) apparatus to apply radio frequency (RF) energy to a volume in an object in a series of variable sequence blocks, where a sequence block includes one or more excitation phases, one or more readout phases, and one or more waiting phases,where the volume contains one or more resonant species,where the RF energy applied during a sequence block is configured to cause the one or more resonant species in the volume to simultaneously produce individual NMR signals, andwhere at least one member of the series of variable sequence blocks differs from at least one other member of the series of variable sequence blocks in at least N sequence block parameters, N being an integer greater than one;
controlling the NMR apparatus to acquire the simultaneously produced individual NMR signals; and
controlling the NMR apparatus to compare the acquired NMR signals to one or more signal evolutions.
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Abstract
Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons.
81 Citations
39 Claims
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1. A method, comprising:
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controlling a nuclear magnetic resonance (NMR) apparatus to apply radio frequency (RF) energy to a volume in an object in a series of variable sequence blocks, where a sequence block includes one or more excitation phases, one or more readout phases, and one or more waiting phases, where the volume contains one or more resonant species, where the RF energy applied during a sequence block is configured to cause the one or more resonant species in the volume to simultaneously produce individual NMR signals, and where at least one member of the series of variable sequence blocks differs from at least one other member of the series of variable sequence blocks in at least N sequence block parameters, N being an integer greater than one; controlling the NMR apparatus to acquire the simultaneously produced individual NMR signals; and controlling the NMR apparatus to compare the acquired NMR signals to one or more signal evolutions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A nuclear magnetic resonance (NMR) apparatus, comprising:
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an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals, where members of the set of NMR signals are associated with different points in the (k, t, E) space, where t is time and E includes at least T1, T2, and one other relaxation parameter, T1 being spin-lattice relaxation, and T2 being spin-spin relaxation, and where one or more of, t, and E, vary non-linearly; a signal logic configured to produce an NMR signal evolution from the set of NMR signals, and a matching logic configured to compare the produced NMR signal evolution to a known NMR signal evolution. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37)
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38. A non-transitory computer-readable medium storing computer executable instructions that when executed by a computer control the computer to perform a method, the method comprising:
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controlling a nuclear magnetic resonance apparatus (NMR) to apply radio frequency (RF) energy suitable to produce nuclear magnetic resonance in a resonant species to a resonant species in a volume, where the NMR apparatus is controlled to apply the RF energy in at least two different sequence blocks that differ in at least the number of α
2 pulses; anddetermining two or more relaxation parameters for the resonant species by pattern matching NMR signals produced by the resonant species to characterizing signal evolutions. - View Dependent Claims (39)
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Specification