System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions
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Abstract
Systems, devices, methods, and compositions are described for providing real-time monitoring of cerebrospinal fluid for markers of progressive conditions.
19 Citations
380 Claims
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1-353. -353. (canceled)
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354. An implantable wireless biotelemetry device, comprising:
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a sensor component configured to detect at least one biomarker profile of a cerebrospinal fluid received within one or more fluid-flow passageways of the implantable wireless biotelemetry device; one or more computer-readable memory media including executable instructions stored thereon that, when executed on a computer, instruct a computing device to retrieve from storage one or more parameters associated with reference cerebrospinal fluid biomarker spectral information associated with at least one neuropsychiatric disorder, and to perform a comparison of a detected at least one biomarker profile to the retrieved one or more parameters; and a transceiver operable to concurrently or sequentially transmit or receive information in response to the comparison. - View Dependent Claims (356, 357, 359, 360, 361, 362, 364, 365)
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355. (canceled)
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358. (canceled)
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363. (canceled)
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366. A method, comprising:
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comparing an in vivo real-time detected measurand of cerebrospinal fluid from an indwelling implant to biological subject specific mental disorder filtering information configured as a physical data structure and stored in one or more non-transitory computer-readable memory media; and generating a response based at least in part on the generated one or more comparisons. - View Dependent Claims (367, 369, 371)
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368. (canceled)
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370. (canceled)
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372. An in vivo method for real-time monitoring of one or more biomarkers within a cerebrospinal fluid, comprising:
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performing an in vivo comparison of a detected change in a spectral absorption profile of one or more biomarkers present in a cerebrospinal fluid received with an implanted shunt to neuropsychiatric disorder information; and transcutaneously transmitting a response based on the comparison of the detected energy spectral profile to the characteristic spectral signature information. - View Dependent Claims (374)
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373. (canceled)
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375. A monitoring method, comprising:
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generating one or more comparisons between at least one in vivo real-time detected measurand from an indwelling implant and biological subject specific mental disorder filtering information configured as a physical data structure and stored in one or more non-transitory computer-readable memory media carried by the indwelling implant; and generating a response based at least in part on the generated one or more comparisons. - View Dependent Claims (376, 377, 379)
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378. (canceled)
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380-391. -391. (canceled)
Specification