System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions
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Abstract
Systems, devices, methods, and compositions are described for providing real-time monitoring of cerebrospinal fluid for markers of progressive conditions.
4 Citations
354 Claims
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1-323. -323. (canceled)
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324. A method, comprising:
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detecting, in vivo, a compositional profile of one or more cerebrospinal fluid measurands obtained at a plurality of sequential time points from a cerebrospinal fluid received within an indwelling implant; partitioning the detected compositional profile into one or more information subsets; and performing a real-time comparison of at least one of the one or more information subsets to reference neuropsychiatric disorder compositional information. - View Dependent Claims (325, 327, 329, 330, 331, 332, 333, 334)
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326. (canceled)
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328. (canceled)
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335. A method, comprising:
executing at least one of a Spectral Clustering protocol and a Spectral Learning protocol operable to compare one or more parameters from an in vivo detected energy spectral profile associated with at least one cerebrospinal fluid component, obtained at a plurality of sequential time points from a cerebrospinal fluid received within an indwelling implant, to one or more information subsets associated with reference neuropsychiatric disorder compositional information. - View Dependent Claims (336, 337, 338, 339, 341, 342, 344, 345, 346, 349, 350, 351)
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340. (canceled)
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343. (canceled)
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347. (canceled)
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348. (canceled)
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352. A method, comprising:
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performing a real-time comparison of a first detected electromagnetic energy absorption profile of a first portion of a cerebrospinal fluid proximate an indwelling implant sensor to characteristic cerebrospinal fluid spectral information; determining whether a neuropsychiatric disorder status change has occurred; obtaining a second detected electromagnetic energy absorption profile of a second portion of a cerebrospinal fluid proximate an indwelling implant sensor; performing a real-time comparison of the second detected optical energy absorption profile to the characteristic cerebrospinal fluid spectral information; and determining whether a neuropsychiatric disorder status change has occurred. - View Dependent Claims (353)
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354-391. -391. (canceled)
Specification