FORMULATIONS FOR C-MET KINASE INHIBITORS

• US 20120241402A1
• Filed: 09/21/2010
• Published: 09/27/2012
• Est. Priority Date: 09/30/2009
• Status: Active Grant

• Current Assignee: Merck Sharp & Dohme Limited (Merck & Co., Inc.)
• Original Assignee: Merck Sharp & Dohme Limited (Merck & Co., Inc.)
• Inventors: Ward, Robert
• Granted Patent: US 9,238,571 B2
• Time in Patent Office: Days
• US Class Current: 212/279
• CPC Class Codes: A61K 31/444 containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1694 resulting in granules or microspheres of the matrix type containing more than 5% of excipient
• CPC Class Codes: A61K 9/2013 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B66C 23/44 Jib-cranes adapted for attachment to standard vehicles, e.g. agricultural tractors
• CPC Class Codes: B66C 23/76 and movable to take account of variations of load or of variations of length of jib

Abstract

A pipelayer providing higher lifting capacities without adding weight or size to an undercarriage or boom of the pipelayer is disclosed. The pipelayer is designed and sized to have a maximum lifting capacity when the boom is extended from the undercarriage a predetermined, relatively short distance. However, in use the boom often needs to extend further away from the undercarriage, and in so doing the lifting capacity of the pipelayer decreases. The present disclosure provides additional lifting capacity in that extended range by selectively deploying a counterweight away from the undercarriage once the boom is extended past the predetermined distance. In so doing, not only is the lifting capacity of the pipelayer increased, but the size and weight of the undercarriage and boom are not increased. This enables standard sized undercarriages and other supporting structure to be used, thereby aiding in maneuverability and shipping of the pipelayers, while at the same time reducing manufacturing and usage costs.

Claims

1. A pipelayer (100), comprising:

an undercarriage (102);

a boom (124) movable relative to the undercarriage (102); and

a counterweight (142) movable relative to the undercarriage (102) ranging between fully deployed and fully refracted positions, the counterweight (148) being deployable only when the boom (124) has extended a predetermined distance from the undercarriage (148).

2. The pipelayer (100) of claim 1, further including an operator interface (164) and a position sensor (158), the operator interface (164) indicating to an operator of the pipelayer (100) that the counterweight (148) can be deployed when the position sensor (158) measures a boom overhang (146) as being greater than the predetermined distance from the undercarriage (102).

3. The pipelayer (100) of claim 2, wherein the predetermined distance is between six and ten feet from the undercarriage (102).

4. The pipelayer (100) of claim 3, wherein the predetermined distance is between four and twenty-eight feet from the undercarriage (102).

5. The pipelayer (100) of claim 1, wherein the counterweight (148) is mounted on a hinged counterweight frame, the hinged counterweight frame having multiple positions between fully deployed and fully retracted.

6. The pipelayer (100) of claim 1, wherein the weight of the counterweight (148) is adjustable.

7. The pipelayer (100) of claim 1, wherein the undercarriage (102) and boom (124) are designed for maximum lifting capacity at a boom overhang (146) of four feet from the undercarriage (102) and the lifting capacity of the pipelayer (100) decreases past a boom overhang (146) of four feet, and wherein the pipelayer (100) has increased lifting capacity when the boom overhang (146) is past four feet without increasing the size or weight of the undercarriage (102) and the boom (124) and without limiting the maximum lifting capacity of the pipelayer (100).

8. The pipelayer (100) of claim 1, further including a position sensor (158) adapted to monitor an overhang distance (146) the boom (124) has extended from the undercarriage (102) and a processor (160) in electronic communication with the position sensor (158).

9. The pipelayer (100) of claim 8, further including an operator interface (162) in electronic communication with the processor (160) and enabling the counterweight (148) to be deployed when the position sensor (158) detects the overhang distance (146) has extended the predetermined distance.

10. The pipelayer (100) of claim 9, further including a hydraulic cylinder (154) operatively coupled to the counterweight (148), the processor (160) automatically causing the hydraulic cylinder (154) to retract the counterweight (148) when the position sensor detects the boom overhang 146 has become less than the predetermined distance.

11. In a pipelayer (100) having an undercarriage (102), chassis (108) and boom (124) weight of A and a machine maximum lifting capacity of B, a heavy-lift attachment (156) adapted to increase the machine maximum lifting capacity to a value greater than B within a heavy lift operating range, while maintaining the undercarriage (102), chassis (108) and boom (124) weight as A.

12. The pipelayer (100) of claim 26, wherein the maximum lifting capacity is increased to at least 1.15 B.

13. The pipelayer (100) of claim 26, wherein the heavy-lift attachment (156) is retrofittable onto existing pipelayers.

14. The pipelayer (100) of claim 26, wherein A is roughly 15,000 pounds and B is roughly 200,000 pounds.

15. The pipelayer (100) of claim 26, wherein the heavy-lift attachment (156) includes a position sensor (158), a processor (160), an operator interface (162), and a counterweight (148).