MULTI-VESSEL COMPUTER CONTROL DRUG DELIVERY

• US 20120245560A1
• Filed: 03/22/2011
• Published: 09/27/2012
• Est. Priority Date: 03/22/2011
• Status: Abandoned Application

• Current Assignee: Milestone Scientific Incorporated
• Original Assignee: Milestone Scientific Incorporated
• Inventors: HOCHMAN, MARK N.
• Application Number:
  US13/053,518
• Publication Number:
  US 20120245560A1
• Time in Patent Office: Days
• US Class Current: 604/518
• CPC Class Codes: A61M 2005/2414 from the side
• CPC Class Codes: A61M 2005/247 with fixed or steady piercing means, e.g. piercing under movement of ampoule
• CPC Class Codes: A61M 2209/01 Remote controllers for specific apparatus
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54

Abstract

Apparatus for combining and subcutaneously injecting a mixture of drug and other liquid such as a buffering solution, uses cartridges with cylinders containing the drug and other liquid, and pistons pushable toward discharge ends of the cylinders for discharging the liquids. A drive unit housing with motor therein is activated by computer to linearly move a motor plunger. A multiple cartridge holder receives cartridges with the drug and other liquid and has a mixing chamber with inlets connected to the discharge ends for receiving a mixture of drug and other liquids. Micro-tubing is connected to an outlet of the chamber and has a handpiece with subcutaneous injection needle at its opposite end for receiving and injecting the mixture. Plural cartridge plungers are engages via a motion transmission to the motor plunger and move into open ends of the cartridges to push the pistons and discharge liquids from the cartridges into the mixing chamber.

Claims

1. An apparatus for combining together and for injecting into a subject, a mixture of a liquid drug and at least one other liquid in desired proportions, the liquid drug and the at least one other liquid each being provided in respective sealed cartridges (114, 116), each cartridge having a cartridge cylinder (113) for containing a quantity of liquid with a sealed discharge end (115) and an opposite open end (117), a cartridge piston (119) in the cartridge cylinder near the opposite open end when the cartridge is full, the piston being pushable toward the discharge end for discharging liquid when the discharge end is punctured, the apparatus comprising:

a drive unit housing (110);

a motor (120) mounted in the drive unit housing;

a motor plunger (122) engaged to the motor for lineal movement with respect to the drive unit housing when the motor is activated;

a computer (124) connected to the motor and programmed with a program for activating the motor to move the motor plunger at selected times and at selected speeds;

a multiple cartridge holder (130) connected to the drive unit housing and adapted to receive a plurality of the cartridges with one of the cartridges containing the liquid drug and at least one other of the cartridges containing the other liquid;

a mixing chamber (132) operatively connected to the multiple cartridge holder (130) and having a plurality of inlets (134) each connectable to the discharge end of one of the cartridges received in the multiple cartridge holder for unsealing each respective discharge end for receiving liquid from each cartridge, the mixing chamber mixing liquids from the cartridges together and having an outlet (135) for discharging a mixture of the liquids;

a length of micro-tubing (136) having one end connected to the outlet of the mixing chamber and an opposite end;

a handpiece assembly (140) connected to the opposite end of the micro-tubing for receiving the mixture of liquid, the handpiece assembly having a subcutaneous injection needle (142) for injecting the mixture of liquids into a subject;

a plurality of cartridge plungers (152, 154) mounted for movement with respect to the drive unit housing (110) and into respective opposite open ends of cartridges (114, 116) received by the multiple cartridge holder (130) for pushing the respective cartridge pistons (119) toward the respective discharge ends to discharge liquids from the cartridges into the mixing chamber;

a motion transmission (160) engaged between the motor plunger (122) and the cartridge plungers (152, 154) for moving the cartridge plungers into the respective opposite open ends of the cartridges when the computer (124) activates the motor (120) to move the motor plunger; and

a foot controller (102) connected to the computer (124) for activating the motor via the program for combining, proportioning, mixing and injecting of the mixture in a hands-free manner.

2. The apparatus according to claim 1, wherein the holder and mixing chamber are made as one unit and of transparent plastic.

3. The apparatus according to claim 1, wherein the motion transmission comprises a plate connected on one side to the motor plunger and on an opposite side to all of the cartridge plungers.

4. The apparatus according to claim 1, wherein the motion transmission comprises an adaptor (360) connected between the drive unit housing (310) over the motor plunger (322), and the multiple cartridge holder (330), a plate mounted for movement in the adapter and connected to the cartridge plungers (352, 354), the plate being engaged and moved by the motor plunger for moving the cartridge plungers (352, 354).

5. The apparatus according to claim 1, wherein the motion transmission comprises an adaptor (460) having an adapter housing (461) connected to the drive unit housing (410) over the motor plunger (422), a plate (462) connected between the motor plunger (422) and the cartridge plungers (452, 454), the cartridge holder (430) being connected to the adapter housing (461) and the cartridge plungers (452, 454) being movable through the adaptor housing (461) and into the open end of cartridges (414, 416) received in the cartridge holder (430).

6. The apparatus according to claim 1, wherein the mixing chamber (432) comprises a Y-shaped section of micro-tubing having two arms (434, 434) forming the inlets of the mixing chamber and a leg (435) forming the mixing chamber outlet, the arms and leg being connected together at a junction for receiving liquids from each of the cartridges (414, 416) received in the cartridge holder (430).

7. The apparatus according to claim 1, wherein the motion transmission comprises an adaptor (560) connected to the drive unit housing (510) over the motor plunger (522), and the multiple cartridge holder comprising a separated holder (530, 531) for receiving each cartridge, a plate (562) mounted for movement to the adapter and connected to the cartridge plungers (552, 554), the plate being engaged and moved by the motor plunger (522) for moving the cartridge plungers.

8. The apparatus according to claim 1, wherein the mixing chamber comprises a Y-shaped section (532) having two arms (534) forming the inlets of the mixing chamber and a leg (535) forming the mixing chamber outlet, the arms and leg being connected together at a junction for receiving liquids from each of the cartridges (514, 516) received in the cartridge holder (430), the motion transmission comprising an adaptor (560) connected to the drive unit housing (510) over the motor plunger (522), and the multiple cartridge holder comprising a separated holder (530, 531) for receiving each cartridge, a plate (562) mounted for movement to the adapter and connected to the cartridge plungers (552, 554), the plate being engaged and moved by the motor plunger (522) for moving the cartridge plungers.

9. The apparatus according to claim 1, wherein the motion transmission comprises an adaptor (760, 860) connected to the drive unit housing over the motor plunger, and a differential gear mechanism between the motor plunger and the cartridge plungers for moving cartridge plungers by different amounts when the motor plunger is moved.

10. The apparatus according to claim 1, wherein the multiple cartridge holder (130) is adapted to receive two of the cartridges, the apparatus including, in combination, first and second sealed cartridges (114, 116) each having a cartridge cylinder (113) for containing a quantity of liquid with a sealed discharge end (115) and an opposite open end (117), a cartridge piston (119) in each cartridge cylinder near the opposite open end when the cartridge is full, the piston being pushable toward the discharge end for discharging liquid when the discharge end is punctured, the liquid in the first cartridge being an analgesic and the liquid in the second cartridge being a buffering solution for the analgesic.

11. In a drive unit comprising:

a drive unit housing (110);

a motor (120) mounted in the drive unit housing;

a motor plunger (122) engaged to the motor for lineal movement with respect to the drive unit housing when the motor is activated;

a computer (124) connected to the motor and programmed with a program for activating the motor to move the motor plunger at selected times and at selected speeds; and

a foot controller (102) connected to the computer (124) for activating the motor for combining, proportioning, mixing and injecting of the mixture in a hands-free manner;

the improvement comprising;

a apparatus for combining together and for injecting into a subject, a mixture of a liquid drug and at least one other liquid in desired proportions, the liquid drug and the at least one other liquid each being provided in respective sealed cartridges (114, 116), each cartridge having a cartridge cylinder (113) for containing a quantity of liquid with a sealed discharge end (115) and an opposite open end (117), a cartridge piston (119) in the cartridge cylinder near the opposite open end when the cartridge is full, the piston being pushable toward the discharge end for discharging liquid when the discharge end is punctured, the apparatus further comprising;

a multiple cartridge holder (130) connected to the drive unit housing and adapted to receive a plurality of the cartridges with one of the cartridges containing the liquid drug and at least one other of the cartridges containing the other liquid;

a mixing chamber (132) operatively connected to the multiple cartridge holder (130) and having a plurality of inlets (134) each connectable to the discharge end of one of the cartridges received in the multiple cartridge holder for unsealing each respective discharge end for receiving liquid from each cartridge, the mixing chamber mixing liquids from the cartridges together and having an outlet (135) for discharging a mixture of the liquids;

a length of micro-tubing (136) having one end connected to the outlet of the mixing chamber and an opposite end;

a handpiece assembly (140) connected to the opposite end of the micro-tubing for receiving the mixture of liquid, the handpiece assembly having a subcutaneous injection needle (142) for injecting the mixture of liquids into a subject;

a plurality of cartridge plungers (152, 154) mounted for movement with respect to the drive unit housing (110) and into respective opposite open ends of cartridges (114, 116) received by the multiple cartridge holder (130) for pushing the respective cartridge pistons (119) toward the respective discharge ends to discharge liquids from the cartridges into the mixing chamber; and

a motion transmission (160) engaged between the motor plunger (122) and the cartridge plungers (152, 154) for moving the cartridge plungers into the respective opposite open ends of the cartridges when the computer (124) activates the motor (120) to move the motor plunger;

wherein the foot controller (102) connected to the computer (124) for activating the motor via the program facilitates combining, proportioning, mixing and injecting of the mixture in a hands-free manner.

12. The apparatus according to claim 11, wherein the holder and mixing chamber are make as one unit and of transparent plastic.

13. The apparatus according to claim 11, wherein the motion transmission comprises a plate connected on one side to the motor plunger and on an opposite side to the cartridge plungers.

14. The apparatus according to claim 11, wherein the motion transmission comprises an adaptor (360) connected between the drive unit housing (310) over the motor plunger (322), and the multiple cartridge holder (330), a plate mounted for movement in the adapter and connected to the cartridge plungers (352, 354), the plate being engaged and moved by the motor plunger for moving the cartridge plungers (352, 354).

15. The apparatus according to claim 11, wherein the motion transmission comprises an adaptor (460) having an adapter housing (461) connected to the drive unit housing (410) over the motor plunger (422), a plate (462) connected between the motor plunger (422) and the cartridge plungers (452, 454), the cartridge holder (430) being connected to the adapter housing (461) and the cartridge plungers (452, 454) being movable through the adaptor housing (461) and into the open end of cartridges (414, 416) received in the cartridge holder (430).

16. The apparatus according to claim 11, wherein the mixing chamber (432) comprises a Y-shaped section of micro-tubing having two arms (434, 434) forming the inlets of the mixing chamber and a leg (435) forming the mixing chamber outlet, the arms and leg being connected together at a junction for receiving liquids from each of the cartridges (414, 416) received in the cartridge holder (430).

17. The apparatus according to claim 11, wherein the motion transmission comprises an adaptor (560) connected to the drive unit housing (510) over the motor plunger (522), and the multiple cartridge holder comprising a separated holder (530, 531) for receiving each cartridge, a plate (562) mounted for movement to the adapter and connected to the cartridge plungers (552, 554), the plate being engages and moved by the motor plunger (522) for moving the cartridge plungers.

18. The apparatus according to claim 11, wherein the mixing chamber comprises a Y-shaped section (532) having two arms (534) forming the inlets of the mixing chamber and a leg (535) forming the mixing chamber outlet, the arms and leg being connected together at a junction for receiving liquids from each of the cartridges (514, 516) received in the cartridge holder (430), the motion transmission comprising an adaptor (560) connected to the drive unit housing (510) over the motor plunger (522), and the multiple cartridge holder comprising a separated holder (530, 531) for receiving each cartridge, a plate (562) mounted for movement to the adapter and connected to the cartridge plungers (552, 554), the plate being engaged and moved by the motor plunger (522) for moving the cartridge plungers.

19. The apparatus according to claim 11, wherein the motion transmission comprises an adaptor (760, 860) connected to the drive unit housing over the motor plunger, and a differential gear mechanism between the motor plunger and the cartridge plungers for moving cartridge plungers by different amount when the motor plunger is moved.

20. The apparatus according to claim 11, wherein the multiple cartridge holder (130) is adapted to receive two of the cartridges, the apparatus including, in combination, first and second sealed cartridges (114, 116) each having a cartridge cylinder (113) for containing a quantity of liquid with a sealed discharge end (115) and an opposite open end (117), a cartridge piston (119) in each cartridge cylinder near the opposite open end when the cartridge is full, the piston being pushable toward the discharge end for discharging liquid when the discharge end is punctured, the liquid in the first cartridge being an analgesic and the liquid in the second cartridge being a buffering solution for the analgesic.

21. A method for combining together and for injecting into a subject, a mixture of a liquid drug and at least one other liquid in desired proportions, the liquid drug and the at least one other liquid each being provided in respective sealed cartridges (114, 116), each cartridge having a cartridge cylinder (113) for containing a quantity of liquid with a sealed discharge end (115) and an opposite open end (117), a cartridge piston (119) in the cartridge cylinder near the opposite open end when the cartridge is full, the piston being pushable toward the discharge end for discharging liquid when the discharge end is punctured, the method comprising:

providing a drive unit housing (110);

providing a motor (120) mounted in the drive unit housing;

providing a motor plunger (122) engaged to the motor for lineal movement with respect to the drive unit housing when the motor is activated;

providing a computer (124) connected to the motor and programmed with a program for activating the motor to move the motor plunger at selected times and at selected speeds;

providing a multiple cartridge holder (130) connected to the drive unit housing and adapted to receive a plurality of the cartridges with one of the cartridges containing the liquid drug and at least one other of the cartridges containing the other liquid;

providing a mixing chamber (132) operatively connected to the multiple cartridge holder (130) and having a plurality of inlets (134) each connectable to the discharge end of one of the cartridges received in the multiple cartridge holder for unsealing each respective discharge end for receiving liquid from each cartridge, the mixing chamber mixing liquids from the cartridges together and having an outlet (135) for discharging a mixture of the liquids;

providing a length of micro-tubing (136) having one end connected to the outlet of the mixing chamber and an opposite end;

providing a handpiece assembly (140) connected to the opposite end of the micro-tubing for receiving the mixture of liquid, the handpiece assembly having a subcutaneous injection needle (142) for injecting the mixture of liquids into a subject;

providing a plurality of cartridge plungers (152, 154) mounted for movement with respect to the drive unit housing (110) and into respective opposite open ends of cartridges (114, 116) received by the multiple cartridge holder (130) for pushing the respective cartridge pistons (119) toward the respective discharge ends to discharge liquids from the cartridges into the mixing chamber;

providing a foot controller (102) connected to the computer (124) for activating the motor via the program;

using a motion transmission (160) engaged between the motor plunger (122) and the cartridge plungers (152, 154) to move the cartridge plungers into the respective opposite open ends of the cartridges when the computer (124) activates the motor (120) to move the motor plunger; and

depressing the foot controller (102) for activating the motor via the program to combine, proportion, mix and inject the mixture in a hands-free manner.