COMPOSITE BONE MATERIAL IMPLANT AND METHOD

• US 20120245703A1
• Filed: 01/23/2012
• Published: 09/27/2012
• Est. Priority Date: 01/02/2004
• Status: Abandoned Application

• Current Assignee: Meredith, Thomas L.
• Original Assignee: Meredith, Thomas L.
• Inventors: Meredith, Thomas L.
• Application Number:
  US13/356,646
• Publication Number:
  US 20120245703A1
• Time in Patent Office: Days
• US Class Current: 623/23.51
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2310/00359 Bone or bony tissue
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46

Abstract

The present invention relates to a method of forming a bone composite, comprising: providing bone tissue; grinding said bone tissue to form ground tissue; molding the ground bone tissue into a bone composite; applying a binder to the bone composite; applying a vacuum to the mold, and optionally milling or refining the bone composite to the desired shape. The present invention includes the use of a carbohydrate, water, cyanoacrylate and demineralized bone.

Claims

1. An injectable bone composite implanted into a bone structure within a species, the injectable bone composite consisting essentially of:

a demineralized bone matrix;

n-butyl cyanoacrylate;

sterilized water; and

carbohydrate.

2. The injectable bone composite of claim 1, wherein the water includes a pH factor greater than 7.0.

3. The injectable bone composite of claim 2, wherein the water is distilled.

4. The injectable bone composite of claim 1, wherein the n-Butyl Cyanoacrylate is absent methyl and ethyl.

5. The injectable bone composite of claim 1, wherein the carbohydrate comprises glucose.

6. The injectable bone composite of claim 1, wherein the carbohydrate is from about 0.05% to about 1% of the total weight of the injectable bone composite.

7. The injectable bone composite of claim 1, wherein the bone matrix comprises sterile allogeneic ground bone sized less than 1000 microns.

8. The injectable bone composite of claim 7, wherein the sterile allogeneic ground bone consists of bone particles sized greater than 10 microns.

9. The injectable bone composite of claim 7, wherein the sterile allogeneic ground bone consists of bone particles sized greater than 125 microns.

10. The injectable bone composite of claim 6, wherein the sterile allogeneic ground bone is freeze-dried.

11. The injectable bone composite of claim 1, wherein the concentration of demineralized bone matrix comprises from about 0.05% to about 1% carbohydrate with the balance of the composite comprising about equal portions of n-Butyl Cyanoacrylate, water and demineralized bone.

12. An injectable bone composite implanted into a bone structure within a species, the injectable bone composite consisting essentially of:

a demineralized bone matrix;

n-butyl cyanoacrylate;

sterilized water; and

glucose.

13. The injectable bone composite of claim 12, wherein the concentration of demineralized bone matrix comprises from about 0.05% to about 1% glucose with the balance of the composite comprising about equal portions of n-Butyl Cyanoacrylate, water and demineralized bone.

14. The method of claim 13, wherein a bone composite with approximately 1% glucose is more osteoinductive than a bone composite with less than 0.01% glucose.

15. The method of claim 13, wherein a bone composite with approximately 1% glucose has less compressive strength than a bone composite with less than 0.01% glucose.

16. A method of forming a bone composite comprising the steps of:

Providing about equal proportions of distilled water, cyanoacrylate, and demineralized bone;

choosing whether the bone composite should be more osetoinductive or have greater compressive strength;

selecting between the addition of a lower percentage of carbohydrate for a composite with greater compressive strength or a higher percentage of carbohydrate for a composite with greater osetoinductivity; and

providing an amount of carbohydrate ranging from about 0.05% of the total weight of the composite to about 1% of the total weight of the composite,

17. The method of claim 16, wherein the carbohydrate is glucose.