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TREATMENT OF LIVER DISORDERS BY ADMINISTRATION OF RAP CONJUGATES

  • US 20120251444A1
  • Filed: 09/18/2007
  • Published: 10/04/2012
  • Est. Priority Date: 03/21/2007
  • Status: Active Grant
First Claim
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1. A method of treating a liver disorder in a subject comprising:

  • administering to said subject an effective amount of a conjugate comprising (a) a receptor binding moiety selected from the group consisting of Receptor Associated Protein of SEQ ID NO;

    1 (RAP), RAP fragments, and RAP variants that retain RAP'"'"'s binding affinity to LRP1 of about 1-5 nM, attached to (b) an active agent for treatment of liver disorder.

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