ANTI-DIABETIC EXTRACT OF HONEYBUSH

• US 20120251643A1
• Filed: 06/11/2012
• Published: 10/04/2012
• Est. Priority Date: 03/12/2007
• Status: Abandoned Application

• Current Assignee: Zadec APS
• Original Assignee: Zadec APS
• Inventors: Larsen, Peter Mose, Fey, Stephen John, Louw, Johan, Joubert, Lizette
• Application Number:
  US13/493,614
• Publication Number:
  US 20120251643A1
• Time in Patent Office: Days
• US Class Current: 424/757
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 36/00 Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines antigens from pollen A61K39/36
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

Novel and useful compositions derived from honeybush plant extract for treating diabetes are provided. It has been found that the plant extract of the present invention exhibit a superior antidiabetic effect when administered in an amount from about 1 milligram to about 5 milligrams, preferably to about 2.5 milligrams, per kilogram body weight.

Claims

1-51. -51. (canceled)

52. A method for treating subjects who are hyperglycaemic with a plant extract obtainable by a method comprising steps of:

(a) providing Cyclopia plants or portions thereof;

(b) solubilizing said plants or portions thereof in a nontoxic solvent and heating the solvent to a temperature between 60°

C. and 95°

C. to provide plant extract; and

(c) recovering said plant extract.

53. A method according to claim 52, further comprising drying the plant extract.

54. A method for treating diabetes, including the prevention of the development of diabetes, with plant extract obtainable by a method comprising steps of:

(a) providing Cyclopia plants or portions thereof,

(b) solubilizing said plants or portions thereof in a nontoxic solvent and heating the solvent to a temperature between 60°

C. and 95°

C. to provide plant extract; and

(c) recovering said plant extract;

wherein said extract is administered in an amount from about 0.1 milligram to about 25 milligrams per kilogram body weight.

55. A method according to claim 54, further comprising drying the plant extract.

56. A method according to claim 54, wherein said extract is administered in an amount from about 1 milligram to about 5 milligrams per kilogram body weight.

57. A method according to claim 54, wherein said extract is administered in an amount from about 1 milligram to about 2.5 milligrams per kilogram body weight.

58. A method of maintaining normal blood glucose levels by administering to a human or animal a plant extract obtainable by a method comprising the steps of:

(a) providing Cyclopia plants or portions thereof;

(b) solubilizing said plants or portions thereof in a nontoxic solvent and heating the solvent to a temperature between 60°

C. and 95°

C. to provide plant extract; and

(c) recovering said plant extract;

wherein said extract is administered in an amount from about 0.1 milligram to about 25 milligrams per kilogram body weight.

59. A method according to claim 58, further comprising drying the plant extract.