MODULATION OF HUNTINGTIN EXPRESSION
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Abstract
Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington'"'"'s disease, or a symptom thereof.
18 Citations
100 Claims
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1-76. -76. (canceled)
- 77. A method for reducing the rate of progression of one or more symptoms of Huntington'"'"'s disease in a subject in need thereof, comprising administering to the subject a compound comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides, wherein said compound specifically hybridizes to a nucleic acid sequence of the huntingtin gene.
Specification