DRONABINOL TREATMENT FOR MIGRAINES

• US 20120252885A1
• Filed: 05/30/2012
• Published: 10/04/2012
• Est. Priority Date: 06/20/2005
• Status: Abandoned Application

• Current Assignee: Lou Barbato
• Original Assignee: Lou Barbato
• Inventors: Barbato, Lou
• Application Number:
  US13/483,211
• Publication Number:
  US 20120252885A1
• Time in Patent Office: Days
• US Class Current: 514/454
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: A61K 9/0075 for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
• CPC Class Codes: A61K 9/008 comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
• CPC Class Codes: A61K 9/48 Preparations in capsules, e.g. of gelatin, of chocolate A61K9/0004 takes precedence; bite capsules A61K9/0056
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

In various embodiments, the present invention provides pharmaceutical compositions comprising delta-9-tetrahydrocannabinol and methods of administering such compositions to treat migraines.

Claims

1. A method of treating migraine headaches comprising administering to a subject in need thereof an effective amount of dronabinol through a metered dose inhaler.

2. The method of claim 1, wherein the metered dose inhaler comprises about 0.5% delta-9-THC, about 10% dehydrated alcohol, and about 89.5.0% 1,1,1,2 tetrafluoroethane.

3. The method of claim 1, wherein the metered dose inhaler comprises about 2.0% delta-9-THC, about 10% dehydrated alcohol, and about 88.0% 1,1,1,2 tetrafluoroethane.

4. The method of claim 1, wherein the metered dose inhaler is obtained from a physician.

5. A method of treating migraine headaches comprising administering to a subject in need thereof an effective amount of dronabinol through an orally deliverable dosage unit.

6. The method of claim 5, wherein the orally deliverable dosage unit is a capsule.

7. A method of treating migraine headaches comprising administering to a subject in need thereof an effective amount of dronabinol through a transdermal delivery system

8. The method of claim 7, wherein the transdermal delivery system is a patch.

9. A method of treating acute migraine headaches in a subject in need thereof comprising treating the periaqueductal region of the brain by administering an effective amount of dronabinol.

10. A method of treating acute migraine headaches in a subject in need thereof comprising reducing platelet aggregation in the subject by administering an effective amount of dronabinol.