HEART FAILURE MONITORING

• US 20120253207A1
• Filed: 03/30/2012
• Published: 10/04/2012
• Est. Priority Date: 04/01/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sarkar, Shantanu, Redemske, Jodi L., Warman, Eduardo N., Hettrick, Douglas A., Ousdigian, Kevin T.
• Granted Patent: US 10,542,887 B2
• Time in Patent Office: Days
• US Class Current: 600/483
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

Techniques for transmitting diagnostic information stored in an implantable medical device (IMD) based on patient hospitalization are described. For example, the IMD may transmit higher resolution diagnostic information to a clinician and/or an external device during a hospitalization period to aid the clinician in evaluating heart failure treatment and when discharge is proper. This higher resolution diagnostic information may include one or more patient metrics automatically generated and transmitted by the IMD at least once every two hours. During a post-hospitalization period, the IMD may transmit lower resolution diagnostic information to a clinician that indicates a risk level of re-hospitalization. The lower resolution diagnostic information may include the risk level and/or patient metrics once a day, for example. In this manner, the IMD transmitted diagnostic information may be tailored to the specific heart failure monitoring needed by the patient.

Claims

1. A method comprising:

storing a plurality of automatically detected patient metrics within an implantable medical device of a patient;

transmitting higher resolution diagnostic information during a hospitalization period of the patient, wherein the higher resolution diagnostic information is based on at least one of the plurality of patient metrics and indicative of heart failure; and

transmitting lower resolution diagnostic information during a post-hospitalization period of the patient, wherein the lower resolution diagnostic information is based on the plurality of patient metrics and indicative of a risk of re-hospitalization due to heart failure.

2. The method of claim 1, wherein the higher resolution diagnostic information comprises values of the at least one patient metric detected at least one of:

once every two hours;

or

on-demand during the hospitalization period.

3. The method of claim 2, wherein the at least one patient metric comprises at least one of an intrathoracic impedance, a thoracic fluid level, an atrial fibrillation duration after cardioversion therapy, a heart rate variability, a stabilization of ventricular rate during persistent atrial fibrillation, a stabilization of night heart rate, and a cardiac resynchronization therapy percentage.

4. The method of claim 1, further comprising:

comparing each of the plurality of automatically detected patient metrics to a respective one of a plurality of metric-specific thresholds; and

automatically generating a heart failure risk level based on the comparison, wherein the heart failure risk level is indicative of the risk of re-hospitalization for heart failure, and wherein the lower resolution diagnostic information comprises the heart failure risk level.

5. The method of claim 4, wherein the heart failure risk level is based on a predetermined number of the plurality of automatically detected patient metrics that each exceed the respective one of the plurality of metric-specific thresholds.

6. The method of claim 5, wherein:

the heart failure risk level indicates a high risk of re-hospitalization when the predetermined number of the plurality of automatically detected patient metrics is two or more automatically detected patient metrics each exceeding the respective one of the plurality of metric-specific thresholds;

the heart failure risk level indicates a medium risk of re-hospitalization when the predetermined number of the plurality of automatically detected patient metrics is one automatically detected patient metric exceeding the respective one of the plurality of metric-specific thresholds;

the heart failure risk level indicates a low risk of re-hospitalization when the predetermined number of the plurality of automatically detected patient metrics is zero automatically detected patient metrics exceeding the respective one of the plurality of metric-specific thresholds; and

the plurality of automatically detected patient metrics includes at least eight different automatically detected patient metrics.

7. The method of claim 5, wherein:

the plurality of automatically detected patient metrics comprises at least two of a thoracic impedance, an atrial fibrillation duration, a ventricular contraction rate during atrial fibrillation, a patient activity, a nighttime heart rate, a heart rate variability, a cardiac resynchronization therapy percentage, a ventricular pacing percentage, and an electrical shock event; and

the plurality of metric-specific thresholds comprise at least two of an atrial fibrillation duration threshold of approximately 6 hours, a ventricular contraction rate threshold approximately equal to 90 beats per minute for 24 hours, a patient activity threshold approximately equal to 1 hour per day for seven consecutive days, a nighttime heart rate threshold of approximately 85 beats per minute for seven consecutive days, a heart rate variability threshold of approximately 40 milliseconds for seven consecutive days, a cardiac resynchronization therapy percentage threshold of 90 percent for five of seven consecutive days, and an electrical shock threshold of 1 electrical shock.

8. The method of claim 1, further comprising generating a heart failure risk level with a Bayesian Belief Network based on the plurality of automatically generated patient metrics, wherein the lower resolution diagnostic information comprises the heart failure risk level.

9. The method of claim 1, further comprising:

remotely interrogating a plurality of implantable medical devices during the post-hospitalization period for a plurality of patients to initiate transmission of lower resolution diagnostic information detected over a predetermined period, wherein each of the plurality of implantable medical devices is implanted in a different one of the plurality of patients;

transmitting lower resolution diagnostic information from each of the implantable medical devices; and

presenting the transmitted lower resolution diagnostic information arranged according to a re-hospitalization risk of each of the plurality of patients.

10. An implantable medical device comprising:

a memory configured to store a plurality of automatically detected patient metrics;

a metric detection module configured to generate higher resolution diagnostic information based on at least one of the plurality of patient metrics and indicative of heart failure and generate lower resolution diagnostic information based on the plurality of patient metrics and indicative of a potential re-hospitalization period due to heart failure; and

a telemetry module configured to transmit the higher resolution diagnostic information during a hospitalization period of the patient and lower resolution diagnostic information during a post-hospitalization period of the patient.

11. The implantable medical device of claim 10, wherein the metric detection module is configured to generate the higher resolution diagnostic information with values of the at least one patient metric detected at least one of once every two hours or on-demand during the hospitalization period.

12. The implantable medical device of claim 10, wherein the at least one patient metric comprises at least one of an intrathoracic impedance, a thoracic fluid level, an atrial fibrillation duration after cardioversion therapy, a heart rate variability, a stabilization of ventricular rate during persistent atrial fibrillation, a stabilization of night heart rate, and a cardiac resynchronization therapy percentage.

13. The implantable medical device of claim 10, wherein the metric detection module is configured to:

compare each of the plurality of automatically detected patient metrics to a respective one of a plurality of metric-specific thresholds; and

automatically generate a heart failure risk level based on the comparison, wherein the heart failure risk level is indicative of the risk of re-hospitalization for heart failure, and wherein the lower resolution diagnostic information comprises the heart failure risk level.

14. The implantable medical device of claim 13, wherein the heart failure risk level is based on a predetermined number of the plurality of automatically detected patient metrics that each exceed the respective one of the plurality of metric-specific thresholds.

15. The implantable medical device of claim 14, wherein:

the heart failure risk level indicates a high risk of re-hospitalization when the predetermined number of the plurality of automatically detected patient metrics is two or more automatically detected patient metrics each exceeding the respective one of the plurality of metric-specific thresholds;

the heart failure risk level indicates a medium risk of re-hospitalization when the predetermined number of the plurality of automatically detected patient metrics is one automatically detected patient metrics exceeding the respective one of the plurality of metric-specific thresholds;

the heart failure risk level indicates a low risk of re-hospitalization when the predetermined number of the plurality of automatically detected patient metrics is zero automatically detected patient metrics exceeding the respective one of the plurality of metric-specific thresholds; and

the plurality of automatically detected patient metrics includes at least eight different automatically detected patient metrics.

16. The implantable medical device of claim 10, wherein the telemetry module is configured to transmit the lower resolution diagnostic information to an external device prior to the hospitalization period.

17. The implantable medical device of claim 10, wherein the telemetry module is configured to switch to transmitting higher resolution diagnostic information during the post-hospitalization period in response to the metric detection module determining one of the plurality of automatically detected patient metrics exceeds a respective one of a plurality of metric-specific thresholds.

18. The implantable medical device of claim 10, wherein the metric detection module is configured to store the plurality of automatically detected patient metrics in the memory with a dynamic data storage rate, and wherein the dynamic storage rate is higher for the higher resolution diagnostic information and lower for the lower resolution diagnostic information.

19. The implantable medical device of claim 10, wherein the telemetry module is configured to initiate transmission of lower resolution diagnostic information detected over a predetermined period in response to receiving a remote interrogation request during the post-hospitalization period.

20. A system comprising:

means for storing a plurality of automatically detected patient metrics within an implantable medical device of a patient; and

means for transmitting information, wherein;

the means for transmitting information comprises means for transmitting higher resolution diagnostic information during a hospitalization period of the patient;

the higher resolution diagnostic information is based on at least one of the plurality of patient metrics and indicative of heart failure;

the means for transmitting information comprises means for transmitting lower resolution diagnostic information during a post-hospitalization period of the patient; and

the lower resolution diagnostic information is based on the plurality of patient metrics and indicative of a potential re-hospitalization period due to heart failure.