PAPER BASED SPECTROPHOTOMETRIC DETECTION OF BLOOD HEMOGLOBIN CONCENTRATION
First Claim
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1. A method for measuring hemoglobin concentration, comprising the acts of:
- emitting a first wavelength of light through a blood sample on a paper medium;
detecting absorbance of the first wavelength of light;
emitting a second wavelength of light through the blood sample on the paper medium;
detecting absorbance of the second wavelength of light; and
calculating a hemoglobin concentration associated with the blood sample based on the detected absorbance of the first wavelength of light and the detected absorbance of the second wavelength of light.
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Abstract
The present disclosure relates to the use of a paper medium to measure blood hemoglobin concentration. In certain embodiments, spectrophotometric techniques are used to measure light transmission at specified wavelengths through a paper medium containing a blood sample. The light transmission information is then used in the calculation of blood hemoglobin concentration. In certain embodiments, the paper medium may be chemically treated to lyse the blood sample prior to measurement of the light transmission information.
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20 Claims
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1. A method for measuring hemoglobin concentration, comprising the acts of:
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emitting a first wavelength of light through a blood sample on a paper medium; detecting absorbance of the first wavelength of light; emitting a second wavelength of light through the blood sample on the paper medium; detecting absorbance of the second wavelength of light; and calculating a hemoglobin concentration associated with the blood sample based on the detected absorbance of the first wavelength of light and the detected absorbance of the second wavelength of light. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. One or more machine readable media encoding routines that, when executed by a processor, cause acts to be performed comprising:
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receiving a first input indicative of absorbance of light at a first wavelength through a blood sample on a paper medium; receiving a second input indicative of absorbance of light at a second wavelength through the blood sample on the paper medium; correcting for baseline intensity in the first input based on the second input to generate a normalized measure of absorbance by hemoglobin; calculating a hemoglobin concentration using the normalized measure. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A method for measuring hemoglobin concentration, comprising the acts of:
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measuring the absorption of light by a blood sample on a paper medium at two wavelengths; subtracting a value representative of the absorption of light at the second wavelength from a value representative of the absorption of light at the first wavelength to derive a normalized absorption value; and calculating a hemoglobin concentration based on the normalized absorption value using an empirically determined correlation or constant relating optical density and hemoglobin concentration. - View Dependent Claims (19, 20)
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Specification