BALLOON CATHETER FOR LAUNCHING DRUG DELIVERY DEVICE

• US 20120259401A1
• Filed: 03/30/2012
• Published: 10/11/2012
• Est. Priority Date: 04/08/2011
• Status: Abandoned Application

• Current Assignee: Sanovas Intellectual Property, LLC
• Original Assignee: Sanovas Intellectual Property, LLC
• Inventors: Gerrans, Lawrence J., Gunday, Erhan H.
• Application Number:
  US13/436,423
• Publication Number:
  US 20120259401A1
• Time in Patent Office: Days
• US Class Current: 623/1.11
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2025/109 having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

A method and apparatus for delivering a therapeutic and/or diagnostic agent to tissue within a bodily cavity is provided herein. The apparatus may include a catheter assembly including a catheter and a delivery balloon having an expandable material disposed thereon, wherein the expandable material may be an absorbent at least partially charged with a therapeutic and/or diagnostic agent. The method may include the step of delivering a therapeutic and/or diagnostic agent to tissue by inflating the delivery balloon by supplying fluid thereto until the expandable material adopts an expanded state in which the expandable material contacts the tissue and is implanted in a bodily cavity.

Claims

1. A method of delivery of a therapeutic and/or diagnostic agent to tissue, comprising the steps of:

inserting a catheter assembly into a bodily cavity, the catheter assembly comprising

a catheter and a delivery balloon;

said delivery balloon having an expandable material disposed thereon;

said expandable material comprising an absorbent at least partially charged with a therapeutic and/or diagnostic agent; and

delivering said therapeutic and/or diagnostic agent to tissue by inflating said delivery balloon by supplying fluid thereto until said expandable material adopts an expanded state in which the expandable material contacts tissue and is implanted in the bodily cavity.

2. The method of claim 1 further comprising the step of recharging at least a portion of said implanted expandable material with a therapeutic and/or diagnostic agent after at least some of said agent has been absorbed by the tissue.

3. The method of claim 1 further comprising the steps of deflating said delivery balloon and removing said delivery balloon from said bodily cavity while said expandable material remains in the expanded state and implanted in said bodily cavity.

5. The method of claim 3 wherein said expandable material further comprises a micro RF tag.

6. The method of claim 1 further comprising the step of curing said expandable material to adopt a rigid shape within said bodily cavity.

7. The method of claim 6 wherein said curing step comprises introducing a probe into said catheter to apply a curing treatment to said expandable material.

8. The method of claim 1 wherein said absorbent is retained on said delivery balloon in a contracted state with at least one string and wherein the step of inflating said delivery balloon causes said at least one string to break such that said absorbent adopts an expanded state within said bodily cavity.

9. The method of claim 1, wherein fluid is supplied to said delivery balloon with an electro-pneumatic pump.

10. The method of claim 1, wherein a vacuum source evacuates fluid from said delivery balloon.

11. The method of claim 1, wherein said fluid is a gas.

4. The method of claim 4 further comprising the step of recharging at least a portion of said implanted expandable material with a therapeutic and/or diagnostic agent after at least some of said agent has been absorbed by the tissue.

12. A balloon catheter for supplying a therapeutic and/or diagnostic agent to tissue, comprising:

a catheter having a distal end and a proximal end;

a delivery balloon positioned near the distal end of said catheter, said delivery balloon having an expandable material disposed thereon;

said expandable material being at least partially charged with a therapeutic and/or diagnostic agent;

a proximal balloon positioned proximal of said delivery balloon and a distal balloon positioned distal of said delivery balloon;

a first lumen in said catheter through which fluid is supplied to said delivery balloon for inflating said delivery balloon until said expandable material adopts an expanded state against the tissue within a bodily cavity; and

at least one additional lumen through which fluid is supplied to said proximal and distal balloons for inflating said proximal and distal balloons;

said proximal and distal balloons, when inflated, creating a chamber between the proximal balloon and the distal balloon.

13. The balloon catheter of claim 12 wherein said expandable material is a stent.

14. The balloon catheter of claim 13 wherein said expandable material further comprises an absorbent disposed on at least a portion of said stent.

15. The balloon catheter of claim 12 wherein said expandable material comprises an absorbent.

16. The balloon catheter of claim 15 wherein said absorbent adopts a rigid shape within a bodily cavity when cured.

17. The balloon catheter of claim 16 further comprising a probe for applying a curing treatment to said absorbent.

18. The balloon catheter of claim 15 wherein said absorbent is retained on said delivery balloon in a contracted state with at least one string, said at least one string being adapted to break when said delivery balloon is inflated.

19. The balloon catheter of claim 12 wherein said expandable material further comprises a micro RF tag.

20. The balloon catheter of claim 12, further comprising at least one fluid source that supplies fluid to said delivery, proximal and distal balloons.

21. The balloon catheter of claim 20, wherein said at least one fluid source further comprises at least one vacuum source that evacuates fluid from said delivery, proximal and distal balloons.

22. The balloon catheter of claim 12 wherein said fluid is a gas.

23. A method of delivery of a therapeutic and/or diagnostic agent to tissue, comprising the steps of:

inserting a catheter assembly into a bodily cavity, the catheter assembly comprising

a catheter and a delivery balloon;

said delivery balloon having an expandable material disposed thereon;

said expandable material being at least partially charged with a therapeutic and/or diagnostic agent; and

delivering said therapeutic and/or diagnostic agent to tissue in a pulsing manner by inflating said delivery balloon until said expandable material contacts tissue in the bodily cavity and then deflating said delivery balloon for a desired number of cycles.

24. The method of claim 23, wherein said expandable material comprises an absorbent.

25. The method of claim 23, further comprising the step of recharging at least a portion of said implanted expandable material with a therapeutic and/or diagnostic agent.

26. A balloon catheter for supplying a therapeutic and/or diagnostic agent to tissue, comprising:

a catheter having a distal end and a proximal end;

a delivery balloon positioned near the distal end of said catheter, said delivery balloon having an expandable material disposed on at least a portion thereof;

said expandable material comprising said absorbent being at least partially charged with a therapeutic and/or diagnostic agent; and

a first lumen in said catheter through which fluid is supplied to said delivery balloon for inflating said delivery balloon until said expandable material adopts an expanded state against the tissue within a bodily cavity.

27. The balloon catheter of claim 26 wherein said absorbent comprises a sleeve around said delivery balloon.

28. The balloon catheter of claim 26 wherein said absorbent adopts a rigid shape within a bodily cavity when cured.

29. The balloon catheter of claim 28 further comprising a probe for applying a curing treatment to said expandable material.

30. The balloon catheter of claim 26 wherein said absorbent is retained on said delivery balloon in a contracted state with at least one string, said at least one string being adapted to break when said delivery balloon is inflated.

31. The balloon catheter of claim 26 wherein said expandable material further comprises a micro RF tag.

32. The balloon catheter of claim 26, further comprising at least one fluid source that supplies fluid to said delivery balloon.

33. The balloon catheter of claim 32, wherein said at least one fluid source further comprises at least one vacuum source that evacuates fluid from said delivery balloon.

34. The balloon catheter of claim 26 wherein said fluid is a gas.

35. A method of delivery of a therapeutic and/or diagnostic agent to tissue, comprising the steps of:

inserting a catheter assembly into a bodily cavity, the catheter assembly comprising

a catheter and a delivery balloon;

said delivery balloon having an expandable material disposed thereon;

said expandable material being at least partially charged with a therapeutic and/or diagnostic agent;

a proximal balloon positioned proximal of said delivery balloon and a distal balloon positioned distal of said delivery balloon; and

at least one fluid source that inflates said delivery, proximal and distal balloons by supplying fluid thereto;

inflating said proximal and distal balloons by supplying fluid thereto to create a chamber between the proximal balloon and the distal balloon; and

delivering said therapeutic and/or diagnostic agent to tissue by inflating said delivery balloon by supplying fluid thereto until said expandable material contacts tissue and is implanted in the bodily cavity.

36. The method of claim 35 further comprising the step of recharging at least a portion of said implanted expandable material with a therapeutic and/or diagnostic agent after at least some of said agent has been absorbed by the tissue.

37. The method of claim 35 further comprising the steps of deflating said delivery balloon and removing said delivery balloon from said bodily cavity, wherein said expandable material remains implanted in said bodily cavity.

38. The method of claim 37 further comprising the step of recharging at least a portion of said implanted expandable material with a therapeutic and/or diagnostic agent.

39. The method of claim 38 wherein said expandable material further comprises a micro RF tag.

40. The method of claim 35 wherein said expandable material is a stent.

41. The method of claim 40 wherein said expandable material further comprises an absorbent disposed on at least a portion of said stent.

42. The method of claim 35 wherein said expandable material comprises an absorbent.

43. The method of claim 42 further comprising the step of curing said absorbent to adopt a rigid shape within said bodily cavity.

44. The method of claim 43 wherein said curing step comprises introducing a probe into said catheter to apply a curing treatment to said absorbent.

45. The method of claim 42 wherein said absorbent is retained on said delivery balloon in a contracted state with at least one string and wherein the step of inflating said delivery balloon causes said at least one string to break such that said absorbent adopts an expanded state within said bodily cavity.

46. The method of claim 35, wherein said at least one fluid source comprises an electro-pneumatic pump.

47. The method of claim 35, wherein said at least one fluid source further comprises at least one vacuum source that evacuates fluid from said delivery, proximal and distal balloons.