DETECTION DEVICE

• US 20120262718A1
• Filed: 04/11/2012
• Published: 10/18/2012
• Est. Priority Date: 04/12/2011
• Status: Active Grant

• Current Assignee: Seiko Epson Corporation (Seiko Group)
• Original Assignee: Seiko Epson Corporation (Seiko Group)
• Inventors: YAMADA, Kohei, HASHIMOTO, Nobuaki
• Granted Patent: US 8,823,941 B2
• Time in Patent Office: Days
• US Class Current: 356/436
• CPC Class Codes: G01N 21/474 Details of optical heads therefor, e.g. using optical fibres
• CPC Class Codes: G01N 21/55 Specular reflectivity
• CPC Class Codes: G01N 21/553 and using surface plasmons fluorescence excitation G01N21/648; enhanced Raman G01N21/658
• CPC Class Codes: G01N 21/554 detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
• CPC Class Codes: G01N 21/658 enhancement Raman, e.g. surface plasmons
• CPC Class Codes: G01N 2291/0215 Mixtures of three or more gases, e.g. air
• CPC Class Codes: G01N 2291/02809 Concentration of a compound, e.g. measured by a surface mass change
• CPC Class Codes: G01N 29/022 Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices microdevices per se B81B
• CPC Class Codes: G01N 5/02 by absorbing or adsorbing components of a material and determining change of weight of the adsorbent, e.g. determining moisture content absorption bulbs B01D53/00

Abstract

A detection device includes a flow channel for a fluid sample, a suction section adapted to draw the fluid sample into the flow channel, an optical device disposed in the flow channel, a light source adapted to irradiate the optical device with light, a light detection section adapted to detect light emitted from the optical device, a microbalance sensor chip having a piezoelectric substrate provided with an oscillation electrode, and disposed in the flow channel, and a quantitative analysis section adapted to perform quantitative analysis on the fluid sample based on output from the light detection section and the microbalance sensor chip. The optical device has a metal nanostructure including projections ranging in size from 1 through 1000 nm, and emits light representing the fluid sample adsorbed to the metal nanostructure.

Claims

1. A detection device comprising:

a flow channel;

a suction section adapted to draw a fluid sample in the flow channel;

an optical device disposed in the flow channel;

a light source adapted to irradiate the optical device with light;

a light detection section adapted to detect light emitted from the optical device;

a microbalance sensor chip disposed in the flow channel, the microbalance sensor chip having a piezoelectric substrate provided with an oscillation electrode; and

a quantitative analysis section adapted to perform quantitative analysis on the fluid sample based on output from the light detection section and the microbalance sensor chip,

wherein the optical device has a metal nanostructure including a projection in a size range of 1 through 1000 nm, and

the optical device emits light representing the fluid sample adsorbed to the metal nanostructure.

2. The detection device according to claim 1, wherein

the optical device and the microbalance sensor chip are disposed side by side in the flow channel in a plan view.

3. The detection device according to claim 1, wherein

the optical device and the microbalance sensor chip are disposed in a stack in the flow channel.

4. The detection device according to claim 3, wherein

the metal nanostructure is formed on the oscillation electrode of the microbalance sensor chip.

5. The detection device according to claim 1, wherein

the piezoelectric substrate is a quartz crystal.

6. The detection device according to claim 1, wherein

the microbalance sensor chip is a surface acoustic wave oscillation device.

7. The detection device according to claim 1, wherein

if a variation in output intensity of the light detection section and a variation in output of the microbalance sensor chip both either increase or decrease,

the quantitative analysis section performs the quantitative analysis based on the output intensity of the light detection section.

8. The detection device according to claim 7, wherein

if the variation in the output intensity of the light detection section and the variation in the output of the microbalance sensor chip oppositely increase or decrease, or

if there is no variation in the output of the microbalance sensor chip,

the quantitative analysis section does not perform the quantitative analysis.

9. A detection device comprising:

an optical device;

a light source selectively irradiating the optical device with light;

a light detection section periodically detecting light emitted from the optical device;

a microbalance sensor chip having a piezoelectric substrate including an oscillation electrode; and

a quantitative analysis section selectively performing quantitative analysis on a fluid sample based on output from the light detection section and the microbalance sensor chip,

wherein the optical device has a nanostructure of projections, and

the optical device emits light indicative of the fluid sample adsorbed to the nanostructure.

10. The detection device according to claim 9, wherein the projections have a size range of 1 through 1000 nm.

11. The detection device according to claim 9, wherein the nanostructure is metallic.

12. A method of selectively perming quantitative analysis on a fluid sample comprising:

providing an optical device having a metal nanostructure of projection;

providing a microbalance sensor chip having a piezoelectric substrate including an oscillation electrode;

exposing the optical device and the microbalance sensor chip to the fluid sample;

irradiating the optical device with light from a light source so that the optical device emits light representing the fluid sample adsorbed to the metal nanostructure; and

detecting the light emitted from the optical device with a light detector;

wherein;

if a variation in output intensity of the light detector and a variation in output of the microbalance sensor chip both either increase or decrease, performing the quantitative analysis based on the output intensity of the light detection section; and

if the variation in the output intensity of the light detector and the variation in the output of the microbalance sensor chip oppositely increase or decrease, or if there is no variation in the output of the microbalance sensor chip, refraining from performing the quantitative analysis and repeating the detecting step.