ANIMAL PARASITE-CONTROL METHOD USING INSECT GROWTH REGULATORS

• US 20120264788A1
• Filed: 06/22/2012
• Published: 10/18/2012
• Est. Priority Date: 09/06/2007
• Status: Active Grant

• Current Assignee: Hartz Mountain Corporation (Unicharm Corporation)
• Original Assignee: Hartz Mountain Corporation (Unicharm Corporation)
• Inventors: ECKER, William, HEMSARTH, Lance
• Granted Patent: US 8,846,722 B2
• Time in Patent Office: Days
• US Class Current: 514/345
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A01N 43/40 six-membered rings
• CPC Class Codes: A01N 47/02 the carbon atom having no bond to a nitrogen atom
• CPC Class Codes: A01N 49/00 Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group , wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group , wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof containing hydrocarbons A01N27/00
• CPC Class Codes: A01N 53/00 Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
• CPC Class Codes: A61K 31/09 having two or more such linkages
• CPC Class Codes: A61K 31/216 of acids having aromatic rings, e.g. benactizyne, clofibrate
• CPC Class Codes: A61K 31/231 having one or two double bonds
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/4402 only substituted in position 2, e.g. pheniramine, bisacodyl
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 33/14 Ectoparasiticides, e.g. scabicides

Abstract

Methods and formulations for treating animal ectoparasites, effective against parasites such as fleas and ticks are provided. The methods comprise topically co-administering a non-mobile insect growth regulator and a mobile insect growth regulator to the animal. Parasiticidal formulations for treating animal ectoparasites are also provided, which can be safe to use and avoid the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of two insect growth regulators, a non-mobile insect growth regulator and a mobile insect growth regulator. The topical formulation can be packaged with the two insect growth regulators together or packaged to prevent mixing of the two insect growth regulators prior to administering the topical insecticide formulation to the animal.

Claims

1. An insecticidal formulation comprising an effective amount of a mobile insect growth regulator component comprising methoprene or hydroprene, which is capable of translocating from one area to another area by vaporizing and redepositing, and a non-mobile insect growth regulator component comprising pyriproxyfen, sufficient to reduce the parasitic infestation of a non-human animal treated with the formulation.

2. The insecticidal formulation of claim 1, wherein the amount of methoprene or hydroprene is between 0.01% and 10% by weight of the total formulation.

3. The insecticidal formulation of claim 1, wherein the amount of pyriproxyfen is between 0.005% and 5% by weight of the total formulation.

4. The insecticidal formulation of claim 1, wherein a weight ratio of methoprene or hydroprene to pyriproxyfen is in the range of 20:

1 to 1;

20.

5. The insecticidal formulation of claim 1, wherein the mobile insect growth regulator component comprises methoprene.

6. The insecticidal formulation of claim 1, wherein the mobile insect growth regulator component comprises hydroprene.

7. The insecticidal formulation of claim 1, further comprising 1% to 99% by weight of a carrier.

8. The insecticidal formulation of claim 7, wherein the carrier is an N,N dialkyl fatty acid amide.

9. The insecticidal formulation of claim 7, wherein the carrier is N,N dimethyl octanamide.

10. The insecticidal formulation of claim 7, wherein the carrier is diisopropyl adipate (DIPA).

11. The insecticidal formulation of claim 1, further comprising n-octyl pyrrolidone.

12. The insecticidal formulation of claim 1, wherein mobile insect growth regulator component and the non-mobile insect growth regulator component are packaged to prevent their mixing prior to administration, and to permit their dispensing simultaneously or nearly simultaneously onto the animal.

13. A method of treating parasitic infestation in a non-human animal, the method comprising topically administering to the animal the insecticidal formulation of claim 1.

14. The method of claim 13, comprising topically administering to the animal the insecticidal formulation of claim 2.

15. A method of treating parasitic infestation in a non-human animal, the method comprising topically co-administering to the animal a mobile insect growth regulator component comprising methoprene or hydroprene, which is capable of translocating from one area to another area by vaporizing and redepositing, and a non-mobile insect growth regulator component comprising pyriproxyfen.

16. The method of claim 15, wherein the amount of methoprene or hydroprene is between 0.01% and 10% by weight of the total administration.

17. The method of claim 15, wherein the amount of pyriproxyfen is between 0.005% and 5% by weight of the total administration.

18. The method of claim 15, wherein the mobile insect growth regulator component comprises methoprene.

19. The method of claim 15, wherein the mobile insect growth regulator component comprises hydroprene.

20. The method of claim 15, wherein the mobile insect growth regulator component and the non-mobile insect growth regulator component are applied to the animal in a single combined formulation.

21. The method of claim 15, wherein the mobile insect growth regulator component and the non-mobile insect growth regulator component are separated to prevent mixing prior to administration, and are dispensed simultaneously or nearly simultaneously onto the animal.

22. The method of claim 15, further comprising applying the mobile insect growth regulator component and the non-mobile insect growth regulator component to a surface in the animal'"'"'s surroundings.