TISSUE-INTEGRATING SENSORS

• US 20120265034A1
• Filed: 10/06/2011
• Published: 10/18/2012
• Est. Priority Date: 10/06/2010
• Status: Active Grant

• Current Assignee: Profusa, Inc.
• Original Assignee: Profusa, Inc.
• Inventors: Wisniewski, Natalie A., Helton, Kristen, McMillan, William A.
• Granted Patent: US 10,463,287 B2
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/0017 transmitting optical signals transmission by light H04B10/00
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/14735 comprising an immobilised reagent
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence

Abstract

Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.

Claims

1. A tissue-integrating sensor for detecting an analyte, the sensor comprising

a tissue-integrating scaffold;

and

one or more sensing moieties, wherein the sensing moieties produce a detectable signal in the presence of the analyte; and

further wherein the sensor provides detection of the analyte when placed into the tissue of a subject.

2. The sensor of claim 1, wherein the scaffold consists of the one or more sensing moieties.

3. The sensor of claim 1, wherein the scaffold comprises a polymer.

4. The sensor of claim 3, wherein the polymer comprises a hydrogel.

5. The sensor of claim 1, wherein the sensing moieties are embedded within the scaffold.

6. The sensor of claim 1, wherein the sensing moieties are attached to the exterior of the scaffold.

7. The sensor of claim 6, further comprising a coating exterior to the sensing moieties.

8. The sensor of claim 1, wherein the scaffold is porous and further wherein at least two of the pores of the scaffold are interconnected.

9. The sensor of claim 1, wherein the sensing moieties comprise microspheres or nanospheres.

10. The sensor of claim 1, wherein the sensor comprises multiple layers.

11. The sensor of claim 1, wherein the sensor comprises one or more fibers.

12. The sensor of claim 1, further comprising one or more calibration moieties.

13. A system for detecting an analyte, the system comprising

a tissue-integrating sensor according to claim 1;

and

a module that generates or measures the signal produced by the sensing moieties.

14. The system of claim 13, further comprising a component selected from the group consisting of a detector, a signal receiver, a signal transmitter, a signal processing component, an energy storage component, a data storage component, a data transmitter, a data display device, a data processing component and combinations thereof.

15. A method for detection of an analyte in a tissue of a subject, the method comprising

integrating a sensor according to claim 1 into the tissue and

detecting the presence of the analyte.