ESTIMATING THE VOLUME OF FLUID IN THERAPEUTIC FLUID DELIVERY DEVICE RESERVOIR

• US 20120265144A1
• Filed: 04/03/2012
• Published: 10/18/2012
• Est. Priority Date: 04/13/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Kalpin, Scott L., Baudino, Michael D.
• Granted Patent: US 8,568,389 B2
• Time in Patent Office: Days
• US Class Current: 604/140
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/152 pressurised by contraction of elastic reservoirs containers for dispensing contents by contraction of an elastic bag provided therein, in general B65D83/0061

Abstract

A number of parameters related to the operation of a fluid delivery device are determined based on pressures within the device sensed using multiple pressure sensors. In one example, the volume of therapeutic fluid within a reservoir of a fluid delivery device is estimated based on a measured pressure differential. In another example, the rate at which a therapeutic fluid is added to or removed from the reservoir is estimated based on the measured pressure differential.

Claims

1. A method comprising:

measuring a pressure within a therapeutic fluid reservoir of an implantable fluid delivery device with a first pressure sensor;

measuring a pressure within a chamber of the fluid delivery device at least partially surrounding the reservoir with a second pressure sensor;

estimating a volume of a therapeutic fluid within the reservoir based on a pressure differential between the measured pressure within the reservoir and the measured pressure within the chamber, wherein estimating the volume comprises estimating a rate at which the therapeutic fluid is added to or removed from the reservoir based on the measured pressure within the reservoir and the measured pressure within the chamber; and

displaying an indication of the estimated rate at which the therapeutic fluid is added to or removed from the reservoir.

2. The method of claim 1, wherein the chamber comprises a propellant gas chamber configured to store a propellant gas configured to regulate the pressure within the reservoir.

3. The method of claim 1, wherein estimating the rate at which the therapeutic fluid is added to or removed from the reservoir comprises estimating the rate based on a rate of change of the pressure differential over time and a pressure sensitivity to volume changes constant for the reservoir.

4. The method of claim 1, wherein estimating the volume of the therapeutic fluid within the reservoir comprises estimating the volume based on the estimated rate at which the therapeutic fluid is added to or removed from the reservoir and a baseline volume of therapeutic fluid in the reservoir.

5. The method of claim 4, wherein the baseline volume comprises a starting volume of therapeutic fluid in the reservoir when the therapeutic fluid is first added to or removed from the reservoir.

6. The method of claim 5, wherein estimating the volume of the therapeutic fluid within the reservoir comprises:

multiplying the estimated rate at which the therapeutic fluid is added to or removed from the reservoir by a time over which the therapeutic fluid is added to or removed from the reservoir; and

adding the starting volume to the estimated rate multiplied by the time.

7. The method of claim 1, further comprising displaying an indication of the estimated volume of the therapeutic fluid within the reservoir.

8. The method of claim 7, wherein displaying the indication of the estimated volume comprises displaying a volume gauge on a computing device communicatively connected to the fluid delivery device.

9. The method of claim 1, further comprising generating an alert when the estimated rate at which the therapeutic fluid is added to or removed from the reservoir is greater than or equal to a maximum recommended refill rate.

10. The method of claim 9, wherein the alert comprises at least one of an audible, visual, or tactile alert.

11. The method of claim 9, wherein generating the alert when the estimated rate at which the therapeutic fluid is added to or removed from the reservoir is greater than or equal to the maximum recommended refill rate comprises displaying an indication to slow down an actual rate at which the therapeutic fluid is added to or removed from the reservoir.

12. The method of claim 1, further comprising:

displaying an indication of one or more of a maximum recommended refill rate and a difference between the estimated rate at which the therapeutic fluid is added to or removed from the reservoir and the maximum recommended refill rate.

19. The system of claim 1, wherein the processor is further configured to control the display device to display an indication of the estimated volume of the therapeutic fluid within the reservoir.

20. The system of claim 19, wherein to control the display device to display the indication of the estimated volume, the processor is configured to control the display device to display a volume gauge on a computing device communicatively connected to the fluid delivery device.

13. A fluid delivery system comprising:

an implantable fluid delivery device comprising;

a reservoir configured to store a therapeutic fluid;

a chamber at least partially surrounding the reservoir;

a first pressure sensor configured to sense a pressure within the reservoir;

a second pressure sensor configured to sense a pressure within the chamber;

a display device; and

a processor configured to receive the sensed measurements of the pressure within the reservoir from the first pressure sensor, receive the sensed measurements of the pressure within the chamber from the second pressure sensor, and estimate a volume of a therapeutic fluid within the reservoir based on a pressure differential between the measured pressure within the reservoir and the measured pressure within the chamber,

wherein to estimate the volume, the processor is configured to estimate a rate at which the therapeutic fluid is added to or removed from the reservoir based on the measured pressure within the reservoir and the measured pressure within the chamber, and

wherein the processor is further configured to control the display device to display an indication of the estimated rate at which the therapeutic fluid is added to or removed from the reservoir.

14. The system of claim 13, wherein the chamber comprises a propellant gas chamber configured to store a propellant gas configured to regulate the pressure within the reservoir.

15. The system of claim 13, wherein to estimate the rate at which the therapeutic fluid is added to or removed from the reservoir, the processor is configured to estimate the rate based on a rate of change of the pressure differential over time and a pressure sensitivity to volume changes constant for the reservoir.

16. The system of claim 13, wherein to estimate the volume of the therapeutic fluid within the reservoir, the processor is configured to estimate the volume based on the estimated rate at which the therapeutic fluid is added to or removed from the reservoir and a baseline volume of therapeutic fluid in the reservoir.

17. The system of claim 16, wherein the baseline volume comprises a starting volume of therapeutic fluid in the reservoir when the therapeutic fluid is first added to or removed from the reservoir.

18. The system of claim 17, wherein to estimate the volume of the therapeutic fluid within the reservoir, the processor is configured to:

multiply the estimated rate at which the therapeutic fluid is added to or removed from the reservoir by a time over which the therapeutic fluid is added to or removed from the reservoir; and

add the starting volume to the estimated rate multiplied by the time.

21. The system of claim 13, wherein the processor is further configured to generate an alert when the estimated rate at which the therapeutic fluid is added to or removed from the reservoir is greater than or equal to a maximum recommended refill rate.

22. The system of claim 21, wherein the alert comprises at least one of an audible, visual, or tactile alert.

23. The system of claim 21, wherein to generate the alert when the estimated rate at which the therapeutic fluid is added to or removed from the reservoir is greater than or equal to the maximum recommended refill rate, the processor is configured to control the display device to display an indication to slow down an actual rate at which the therapeutic fluid is added to or removed from the reservoir.

24. The system of claim 13, wherein the processor is further configured to:

control the display device to display an indication of one or more of a maximum recommended refill rate and a difference between the estimated rate at which the therapeutic fluid is added to or removed from the reservoir and the maximum recommended refill rate.

25. A computer-readable storage medium comprising instructions for causing a programmable processor to:

measure a pressure within a therapeutic fluid reservoir of an implantable fluid delivery device with a first pressure sensor;

measure a pressure within a chamber of the fluid delivery device at least partially surrounding the reservoir with a second pressure sensor;

estimate a volume of a therapeutic fluid within the reservoir based on a pressure differential between the measured pressure within the reservoir and the measured pressure within the chamber, wherein the instructions that cause the processor to estimate the volume comprise instructions that cause the processor to estimate a rate at which the therapeutic fluid is added to or removed from the reservoir based on the measured pressure within the reservoir and the measured pressure within the chamber; and

display an indication of the estimated rate at which the therapeutic fluid is added to or removed from the reservoir.

26. A system comprising:

a first means for measuring a pressure within a therapeutic fluid reservoir of an implantable fluid delivery device;

a second means for measuring a pressure within a chamber of the fluid delivery device at least partially surrounding the reservoir; and

means for estimating a volume of a therapeutic fluid within the reservoir based on a pressure differential between the measured pressure within the reservoir and the measured pressure within the chamber, wherein the means for estimating the volume comprises means for estimating a rate at which the therapeutic fluid is added to or removed from the reservoir based on the measured pressure within the reservoir and the measured pressure within the chamber; and

means for displaying an indication of the estimated rate at which the therapeutic fluid is added to or removed from the reservoir.