DEVICES AND METHODS FOR ENHANCING DRUG ABSORPTION RATE

• US 20120265166A1
• Filed: 04/06/2010
• Published: 10/18/2012
• Est. Priority Date: 03/30/2009
• Status: Abandoned Application

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: Yodfat, Ofer
• Application Number:
  US13/260,820
• Publication Number:
  US 20120265166A1
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 25/0606 "Over-the-needle" catheter assemblies, e.g. I.V. catheters
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Devices, systems and methods directed to a drug delivery device including a soft subcutaneously insertable cannula are disclosed. Some embodiments of the cannula include an elongated soft tube having a plurality of apertures spaced around and/or along a wall of the elongated soft tube. The plurality of apertures is configured for fluid flow therethrough resulting-in/causing an increase in an absorption rate of the fluid in the body of the user. The drug delivery device can be an insulin pump.

Claims

1-36. -36. (canceled)

37. A drug delivery device for dispensing a drug into a tissue of a user/patient, the device comprising:

a reservoir for retaining a drug;

a cannula insertable into a tissue of a user/patient;

a pump for dispensing the drug from the reservoir into the tissue via the cannula, wherein;

the cannula comprises a soft tube having a plurality of apertures, the plurality of apertures being configured for delivering the drug into the tissue.

38. The device of claim 37, wherein the tube comprises a flexible tube.

39. The device of claim 37, wherein the apertures are disposed at one of around and along the tube.

40. The device of claim 37, further comprising a plurality of tubes.

41. The device of claim 37, wherein the plurality of apertures causes an increase in absorption rate of the drug in the tissue.

42. The device of claim 37, wherein the plurality of apertures are adapted to form a plurality of depots for the drug.

43. The device of claim 42, wherein the plurality of depots further correspond to an effective diffusion area substantially larger than an effective diffusion area formed from a single aperture forming a single depot.

44. The device of claim 37, wherein the tissue comprises a subcutaneous tissue and/or an intradermal tissue.

45. The device of claim 37, wherein at least one of the plurality of apertures is located in cutaneous tissue.

46. The device of claim 37, wherein:

the cannula is provided with a penetrating member having a sharp tip, the penetrating member is longitudinally traversable through the cannula, and after cannula insertion into the tissue, the penetrating member is retracted and the cannula is retained within the tissue.

47. The device of claim 37, wherein the pump is contained within at least one housing, the at least one housing is configured for repeated connection and disconnection to and from a skin adherable cradle, wherein the skin adherable cradle is provided with a passageway, and the cannula is insertable into the tissue through the passageway and is connected to the cradle after insertion.

48. The device of claim 37, wherein a proximal end of the soft tube is provided with a connector for establishing fluid communication between the reservoir and the cannula.

49. The device of claim 48, wherein the connector is fitted with a self-sealable septum, and wherein the self-sealable septum is configured for repeated piercing by a needle.

50. The device of claim 37, wherein the cannula and/or tube is made of a polymer.

51. The device of claim 37, wherein the plurality of apertures are configured with substantially similar dimensions.

52. The device of claim 37, wherein at least one aperture of the plurality of apertures is configured with one or more dimensions different from another aperture of the plurality of apertures.

53. The device of claim 37, wherein the cannula comprises a tip, and wherein the tip is provided with an opening.

54. The device of claim 53, wherein said opening is further adapted with a self-sealable septum.

55. The device of claim 37, wherein one or more of the plurality of apertures include at least one unidirectional valve.

56. The device of claim 37, wherein the cannula is configured for insertion into the skin of the user substantially perpendicular with respect to the skin surface.

57. The device of claim 37, wherein the cannula is configured for insertion into the skin of the user at an angle with respect to the skin surface.

58. The device of claim 37, wherein the cannula is configured for connection with a sensor, and wherein said sensor is capable of sensing an analyte concentration.

60. A cannula for dispensing of a drug into a tissue of a user/patient, the cannula comprising:

an elongated tube having a plurality of apertures disposed at least one of around and along the elongated tube, the plurality of apertures configured for delivering the drug into the tissue;

a connector provided on a proximal end of the tube for establishing fluid communication between a fluid delivery device and the cannula;

wherein the cannula is insertable into the tissue by using a rigid penetrating member having a sharp tip and,

wherein the plurality of apertures causes an increase in an absorption rate of the fluid in the body of the user/patient.

61. The cannula of claim 60, wherein the tube comprises a flexible tube.

62. A method for increasing the absorption rate of a therapeutic fluid in the body of a user/patient comprising:

providing a cannula for dispensing of the therapeutic fluid into a tissue of a user/patient, the cannula comprising;

a soft tube having a plurality of apertures, the plurality of apertures being configured for delivering the fluid to the tissue;

a connector provided on a proximal end of the soft tube for establishing fluid communication between a fluid delivery device and the cannula;

inserting the cannula into a tissue of the user/patient via a rigid penetrating member having a sharp tip;

and

dispensing the therapeutic fluid through the cannula, wherein the therapeutic fluid flows through the plurality of apertures and into the tissue of the user/patient resulting in an increase in the absorption rate of the therapeutic fluid in the body of the user/patient.