ENGINEERED PROTEINS INCLUDING MUTANT FIBRONECTIN DOMAINS
First Claim
Patent Images
1. An engineered protein comprising a first genetically modified fibronectin domain that binds a first epitope on a molecular target and a second genetically modified fibronectin domain that binds a second epitope on the target.
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Abstract
The present invention features engineered proteins that can include a genetically modified Fn domain; two or more such domains joined to one another; or at least one genetically modified Fn domain joined to a target-specific protein scaffold. One or more accessory sequences can be included in or added to any of these configurations. Methods of use, including methods of treating cancer, with the engineered proteins are also disclosed.
61 Citations
54 Claims
- 1. An engineered protein comprising a first genetically modified fibronectin domain that binds a first epitope on a molecular target and a second genetically modified fibronectin domain that binds a second epitope on the target.
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- 30. An engineered protein comprising (a) a genetically modified fibronectin domain that specifically binds a first epitope on a receptor tyrosine kinase and (b) a heterologous protein that specifically binds a second epitope on the tyrosine kinase receptor.
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33-36. -36. (canceled)
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38-40. -40. (canceled)
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42-47. -47. (canceled)
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50. (canceled)
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54-55. -55. (canceled)
Specification