PREDICTIVE MODELING

• US 20120271612A1
• Filed: 04/20/2012
• Published: 10/25/2012
• Est. Priority Date: 04/20/2011
• Status: Abandoned Application

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Barsoum, Wael K., Kattan, Michael W., Morris, William H., Johnston, Douglas R.
• Application Number:
  US13/451,984
• Publication Number:
  US 20120271612A1
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

This disclosure relates to predictive modeling. Systems and methods can be utilized extract data from a plurality of data sources to provide a set of predictor variables. The predictor variables can be analyzed to generate a model having a portion of the predictor variables with weighted coefficients according to an event or outcome for which the model is generated. A prediction tool can employ the model to predict the even or outcome for one or more patients.

Claims

1. A computer implemented method, comprising:

extracting patient data from a database, the patient data comprising final coded data for each of a plurality of patients and encounter patient data for at least a subset of the plurality of patients;

assigning a value to each code in a set of possible codes for each respective patient based on comparing data for each patient in the final coded data relative to the set of possible codes to provide model data;

storing the model data in memory;

assigning a value to each code of the set of possible codes for each respective patient in the subset of patients based on comparing data for each patient in the encounter patient data relative to the set of possible codes to provide testing data;

storing the testing data in the memory;

generating a model for predicting a selected patient event or outcome, the model having a plurality of predictor variables, corresponding to a selected set of the possible codes, derived from the model data, each of the predictor variables having coefficients calculated from the testing data based on a concordance index of the respective predictor variable to the patient event or outcome; and

storing the model in the memory.

2. The method of claim 1, further comprising:

prior to generating the model, computing a ranked list of predictor variables from the set of possible codes that ranks each of the predictor variables according to their relative efficacy in predicting the event or outcome based on the model data; and

selecting a subset of the predictor variables from the ranked list, the model being generated based on the selected subset of predictor variables.

3. The method of claim 2, wherein the predictor variables are combined according to a principle component analysis.

4. The method of claim 3, wherein the principle component analysis comprises a method programmed to generate a second set of the predictor variables from the model data as a weighted combination of codes selected from the set of possible codes, the model being generated from the second set of the predictor variables.

5. The method of claim 2, wherein both the ranking and the selecting of the subset of predictor variables are performed according to a least absolute shrinkage and selection operator (LASSO) method applied to the model data.

6. The method of claim 5, wherein the predictor variables comprise ICD codes and procedure codes.

7. The method of claim 2, wherein the generation of the model further comprises computing coefficients for the selected subset of predictor variables based on a concordance correlation coefficient method applied to at least a portion of the testing data.

8. The method of claim 2, wherein the generating comprises generating a plurality of models for predicting a given patient event or condition, each of the plurality of models having a corresponding set of predictor variables with respective coefficients, the method further comprising:

receiving an input encounter data set for a certain patient;

selecting one of the plurality of models based on the input encounter data set; and

calculating a predicted patient event or condition for the certain patient based on the selected model and the input encounter data set.

9. The method of claim 8, wherein the input encounter data set comprises longitudinal patient data for the certain patient, the selected model is selected based on the longitudinal patient data.

10. The method of claim 1, wherein the patient encounter data comprises patient data entered by one or more health care professional during a given patient encounter, and

wherein the final coded data comprises patient data that is coded following patient discharge of each patient according to the set of possible codes.

11. The method of claim 10, wherein the set of possible codes comprises ICD codes and procedure codes.

12. The method of claim 11, wherein the set of possible codes further comprises data representing gender and age for each patient.

13. The method of claim 10, further comprising assigning a unique identifier for each patient that is common across each of the model data and the patient encounter data for each respective patient such that data for a given patient is associated with the same unique identifier in both the model data and the patient encounter data.

14. The method of claim 1, further comprising applying a set of patient encounter data for a given patient to the model to generate an output, the output comprising at least one of a predicted diagnosis for the given patient and a predicted prognosis for the given patient.

15. The method of claim 1, further comprising receiving an input encounter data set for a given patient, the input encounter data set comprising longitudinal patient data for the given patient;

and

modifying the model for the given patient based on the longitudinal patient data to provide an encounter-specific model to facilitate prediction for the given patient; and

applying the input encounter data set to the encounter-specific model to provide a predicted output of a predicted patient event or condition for the given patient.

16. The method of claim 15, wherein the method further comprises:

generating a longitudinal model based on statistical analysis of the longitudinal patient data for each of the plurality of patients; and

aggregating the longitudinal model with the encounter-specific model to provide an aggregate predictive model.

17. The method of claim 1, wherein each assigning of the value further comprises dummy coding to indicate which data elements in the set of possible codes match corresponding data elements in the final coded data for each of the plurality of patients and in the patient encounter data for the subset of the patients.

18. The method of claim 1, wherein the patient data further comprises clinical data representing at least one clinical condition for at least some of the patients in the final coded data and at least some of patients in the patient encounter data, the clinical data being represented by natural values according to the clinical condition represented thereby, the method further modifying the model to include at least one clinical predictor variable and associated weight value based on analysis of the clinical data.

19. A system comprising:

memory to store computer readable instructions and data;

a processing unit to access the memory and execute the computer readable instructions, the computer readable instructions comprising;

an extractor programmed to extract patient data from at least one data source, the patient data comprising a final coded data set for each of a plurality of patients and a patient encounter data set for at least a subset of the plurality of patients;

data inspection logic programmed to assign a value to each code of a set of possible codes for each patient based on comparing data for each respective patient in the final coded data set relative to the set of possible codes to provide a modeling data set, the data inspection logic also being programmed to assign a value to each code of the set of possible codes based on comparing data for each patient in the patient encounter data set relative to the set of possible codes to provide a testing data set; and

a model generator programmed to generate a model having a plurality of predictor variables, corresponding to a selected set of the possible codes, each of the predictor variables having coefficients calculated based on a concordance index of each respective variable to a selected patient event or outcome for which the model is generated.

20. The system of claim 19, wherein the computer readable instructions further comprise:

a predictor selector, wherein prior to generating the model, the predictor selector being programmed to compute a ranked list of predictor variables from the set of possible codes that ranks each of the predictor variables according to their relative efficacy in predicting the event or outcome based on the modeling data, the predictor selector being programmed to select a subset of the predictor variables from the ranked list to define the predictor variables in the model.

21. The system of claim 20, wherein the predictor variables comprise a subset of ICD codes and procedure codes, wherein the predictor selector ranks and selects ICD codes and procedure codes to define the predictor variables for the model according to a least absolute shrinkage and selection operator (LASSO) method applied to the model data,

the model generator being programmed to compute the coefficients for the selected subset of predictor variables based on a concordance correlation coefficient method applied to at least a portion of the testing data set.

22. The system of claim 19, wherein the set of possible codes further comprises data representing gender and data representing age for each patient, the extractor assigning a value to the data representing age for each patient and a value to the data representing gender for each patient, such that the model accounts for gender and age in predicting the event or outcome for a given patient.

23. The system of claim 19, wherein the computer readable instructions further comprise:

a prediction tool configured to predict an event or outcome for a given patient based on applying the model to an input set of patient data acquired for the given patient; and

an output generator configured to generate an output corresponding to the predicted event or outcome.

24. The system of claim 19, wherein model is an encounter-specific model, the computer readable instructions further comprise:

a model modification function programmed to generate a longitudinal model based on statistical analysis of longitudinal patient data for each of the plurality of patients, the model modification function being programmed to aggregate the longitudinal model with the encounter-specific model to provide an aggregate model for predicting the event or outcome.

25. The system of claim 19, wherein the event or outcome comprises length of stay for a patient.