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CONTROLLED NUCLEATION DURING FREEZING STEP OF FREEZE DRYING CYCLE USING PRESSURE DIFFERENTIAL ICE FOG DISTRIBUTION

  • US 20120272544A1
  • Filed: 04/29/2011
  • Published: 11/01/2012
  • Est. Priority Date: 04/29/2011
  • Status: Active Grant
First Claim
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1. A method of controlling and enhancing the nucleation of product in a freeze dryer, comprising:

  • maintaining the product at a predetermined temperature and pressure in a chamber of the freeze dryer;

    creating a predetermined volume of ice fog in a condenser chamber separate from the product chamber and connected thereto by a vapor port, the ice fog having a predetermined pressure that is greater than that of the product chamber; and

    rapidly conveying the ice fog through the vapor port into the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.

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