Analysis Device

• US 20120273368A1
• Filed: 04/25/2012
• Published: 11/01/2012
• Est. Priority Date: 04/26/2011
• Status: Active Grant

• Current Assignee: ARKRAY, Inc
• Original Assignee: ARKRAY, Inc
• Inventors: Tsukada, Masashi
• Granted Patent: US 9,045,790 B2
• Time in Patent Office: Days
• US Class Current: 205/775
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 2333/902 Oxidoreductases (1.)
• CPC Class Codes: G01N 2333/904 acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875

Abstract

An analysis device is disclosed which includes an electron detection medium to obtain information needed for analyzing an analyte in correlation with an electron transfer level, and a reagent part which is disposed on the electron detection medium and includes an electron transporting substance to transport electrons between the analyte and the electron detection medium, the electron transporting substance including a water-soluble aromatic heterocycle compound, and being free of a metal complex. An analysis method using the analysis device is also disclosed.

Claims

1. An analysis device comprising:

an electron detection medium to obtain information needed for analyzing an analyte in correlation with an electron transfer level; and

a reagent part which is disposed on the electron detection medium and comprises an electron transporting substance to transport electrons between the analyte and the electron detection medium, the electron transporting substance comprising a water-soluble aromatic heterocycle compound, and being free of a metal complex.

2. The analysis device according to claim 1, wherein the electron transporting substance comprises at least one water-soluble aromatic heterocycle compound selected from the group consisting of pyridine compounds and imidazole compounds.

3. The analysis device according to claim 1, wherein the water-soluble aromatic heterocycle compound has a molecular weight of 1,000 or less.

4. The analysis device according to claim 1, wherein the reagent part further comprises an electron transfer compound that transfers an electron to or from the analyte.

5. The analysis device according to claim 4, wherein the electron transfer compound is an oxidoreductase.

6. The analysis device according to claim 4, wherein a concentration of the electron transporting substance is a concentration that allows transportation of electrons between the electron detection medium and the electron transfer compound.

7. The analysis device according to claim 1, wherein a concentration of the electron transporting substance is from 10 mass % to 60 mass % based on a total mass of the reagent part.

8. The analysis device according to claim 1, wherein the electron transporting substance comprises at least one water-soluble aromatic heterocycle compound selected from the group consisting of pyridine and aminomethyl pyridine.

9. The analysis device according to claim 1, wherein the reagent part comprises a crosslinked substance.

10. The analysis device according to claim 1, wherein the reagent part comprises a crosslinked substance obtained by crosslinking using at least one selected from the group consisting of glutaraldehyde, carbodiimide compounds and succinimide esters.

11. The analysis device according to claim 1, wherein the electron detection medium is an electric conductor.

12. The analysis device according to claim 1, wherein the analyte is a saccharide.

13. An analysis method comprising obtaining information needed for analyzing an analyte based on an electron transfer level of the analyte using the analysis device according to claim 1.