Apparatus and Method for Enhanced HGH Generation in Humans

• US 20120277641A1
• Filed: 04/26/2011
• Published: 11/01/2012
• Est. Priority Date: 04/26/2011
• Status: Active Grant

• Current Assignee: Vasper Systems LLC
• Original Assignee: Vasper Vitality, LLC
• Inventors: Wasowski, Peter Z.
• Granted Patent: US 10,357,421 B2
• Time in Patent Office: Days
• US Class Current: 601/15
• CPC Class Codes: A61F 2007/0002 Head or parts thereof
• CPC Class Codes: A61F 2007/0024 Back
• CPC Class Codes: A61F 2007/0029 Arm or parts thereof
• CPC Class Codes: A61F 2007/0039 Leg or parts thereof
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/0091 inflatable
• CPC Class Codes: A61F 2007/0093 programmed
• CPC Class Codes: A61H 2201/0214 cooled
• CPC Class Codes: A61H 2201/0264 using heat exchanger, e.g. between fresh and used fluids
• CPC Class Codes: A61H 2201/5071 Pressure sensors
• CPC Class Codes: A61H 2203/0456 Supine
• CPC Class Codes: A61H 2205/02 Head
• CPC Class Codes: A61H 2205/06 Arms
• CPC Class Codes: A61H 2205/10 Leg
• CPC Class Codes: A61H 2230/255 used as a control parameter for the apparatus
• CPC Class Codes: A61H 9/0078 with intermittent or alternately inflated bladders or cuffs mattresses for preventing bed-sores with alternated pressurized chambers A61G7/05776
• CPC Class Codes: A63B 2213/006 under hypoxy conditions, i.e. oxygen supply subnormal
• CPC Class Codes: A63B 2225/66 Cooled
• CPC Class Codes: B64G 1/60 Crew or passenger accommodations
• CPC Class Codes: B64G 1/66 Arrangements or adaptations of apparatus or instruments, not otherwise provided for

Abstract

A conditioning process for the enhanced production of human growth hormone in a human has a first step of application of pressurized cooling to the limbs of a subject, who experiences a ramp-up exertion followed by a series of conditioning cycles, followed by a ramp-down cycle. The condition cycles include an interval of intense exertion followed by an interval of reduced exertion, and during ramp-up cycle, conditioning cycle, and ramp-down cycle, the pressure cooling to the limbs is set as a fraction of systolic blood pressure, with the fraction in the range 33% to 220%.

Claims

1. ) A process for generation of human growth hormone in a subject having a systolic blood pressure, the process operative on one or more pressurizable cuffs developing an operational pressure by pumping a chilled coolant from a chilled coolant reservoir through said pressurized cuff and thereafter through a regulation valve for each said pressurized cuff which controls the return of chilled coolant to the coolant reservoir, each said pressurized cuff additionally having a transducer to measure subject blood flow, the process having:

a first step of placing subject extremities in said pressurizable cuff;

a second step of using said transducer to measure a systolic blood pressure by varying at least one said regulation valve associated with said cuff;

a third ramp-up step during a subject exertion interval whereby said pressurized cuff has a ramp-up coolant pressure P in the range of 33% to 220% of said measured systolic blood pressure, said pressurized cuff developing said ramp-up coolant pressure by control of said regulation valve of said cuff which returns said coolant to said coolant reservoir, said pressurized coolant at a temperature and pressure sufficient to reduce circulation in a subject;

a fourth step of a sequence of N conditioning cycles, each conditioning cycle having an intense exertion interval performed by the subject followed by a reduced exertion interval performed by the subject, the intense exertion interval requiring substantially greater subject exertion than the ramp-up subject exertion;

a fifth cool-down step of removing pressure from said pressurized cuffs by opening said regulation valves, and thereafter placing the subject in a substantially horizontal position and applying a cooled liquid contained in a flexible bladder to a spinal region for cooling of a patient cerebral spinal fluid (CSF).

2. ) The method of claim 1 where said subject is a human.

3. ) The method of claim 1 where said chilled coolant delivered by said pump to said pressurized cuffs has a temperature of 38 to 68 degrees Fahrenheit.

4. ) The method of claim 1 where said third step pressure P is periodically recomputed from a new value of systolic blood pressure.

5. ) The method of claim 1 where said subject is a human and at least two of said pressurized cuffs are applied to the legs.

6. ) The method of claim 1 where said subject is a human and at least two of said pressurized cuffs are applied to the arms.

7. ) The method of claim 1 where said fifth step bladder has a central elongate region with an incrementally lower temperature than a region which surrounds said elongate region.

8. ) The method of claim 7 where said fifth step bladder central elongate region is at a temperature between 38 to 68 degrees Fahrenheit and said region which surrounds said elongate region is at a temperature which is below that of said central elongate region.

9. ) The method of claim 1 where said first step systolic blood pressure measurement causes a regulation valve associated with a particular pressure cuff to close until said transducer no longer detects a blood flow, said systolic pressure being the pressure measured at the regulation valve inlet at the time said blood flow is no longer detected.

10. ) A process for generation of human growth hormone in a subject having a systolic blood pressure, the process operative on one or more pressurized cuffs developing said operational pressure by pumping a chilled coolant from a chilled coolant reservoir through said pressurized cuff and thereafter through a regulation valve for said pressurized cuff which controls the return of chilled coolant to the coolant reservoir, each said pressurized cuff additionally having a transducer to measure subject blood flow, the process having:

a first step of placing subject extremities in said pressurized cuff;

a second ramp-up step during a subject exertion interval whereby said pressurized cuff has a ramp-up coolant pressure P in the range of 33% to 220% of said measured systolic blood pressure, said pressurized cuff developing said ramp-up coolant pressure by control of said regulation valve of said cuff which returns said coolant to said coolant reservoir, said pressurized coolant at a temperature and pressure sufficient to reduce circulation in a subject;

a third step of a sequence of N conditioning cycles, each conditioning cycle having an intense exertion interval performed by the subject followed by a reduced exertion interval performed by the subject, the intense exertion interval requiring substantially greater subject exertion than the ramp-up subject exertion;

a fourth cool-down step of removing pressure from said pressurized cuffs by opening said regulation valves, and thereafter placing the subject in a substantially horizontal position and applying a cooled liquid contained in a flexible bladder to a spinal region for cooling of a patient cerebral spinal fluid (CSF).

11. ) The method of claim 10 where said subject is a human.

12. ) The method of claim 10 where said chilled coolant delivered by said pump to said pressurized cuffs has a temperature of 38 to 68 degrees Fahrenheit.

13. ) The method of claim 10 where said second step pressure varies with systolic blood pressure.

14. ) The method of claim 10 where said subject is a human and at least two of said first step pressurized cuffs are applied to the legs.

15. ) The method of claim 10 where said subject is a human and at least two of said pressurized cuffs are applied to the arms.

16. ) The method of claim 10 where said first step systolic blood pressure measurement causes a regulation valve associated with a particular pressure cuff to close until said transducer no longer detects a blood flow, said systolic pressure being the pressure measured at the regulation valve inlet.

17. ) A method for generating increased HGH production in a human subject, the method having:

a first step where a human subject exercises aerobically for 20 minutes or more;

a second step where said human subject is placed on a substantially horizontal surface with a liquid cooled bladder circulating a liquid thermally coupled to said human subject spine and sufficient to cool the CSF of said human subject.

18. ) The method of claim 17 where said flexible bladders are coupled to a local ground potential.