Attachment of a Biomaterial to Tissue

• US 20120277773A1
• Filed: 02/24/2012
• Published: 11/01/2012
• Est. Priority Date: 04/27/2011
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Tyco Healthcare Group LP (Medtronic Plc)
• Inventors: Sargeant, Timothy, Thomas, Jonathan
• Granted Patent: US 8,968,760 B2
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61L 31/04 Macromolecular materials

Abstract

A method for attaching an implant to tissue is disclosed. In embodiments, a method includes applying a sprayable material to tissue, the sprayable material possessing functional groups capable of binding to tissue. The sprayable material also possesses functional groups capable of binding to an implant. In embodiments, the functional groups capable of binding to an implant include nucleotides. In such a case, the implant possesses complementary nucleotides capable of binding to the nucleotides on the sprayable material, thereby permitting hydrogen binding between the two. The implant may thus be affixed to tissue, and repositioned as necessary, prior to more permanent attachment utilizing means such as sutures, tacks, etc.

Claims

1. A method comprising:

applying a sprayable material to tissue, the sprayable material comprising at least one functional group capable of binding to tissue and at least one nucleotide;

allowing the at least one functional group on the sprayable material to bind to the tissue;

applying an implant to the sprayable material, the implant possessing at least a second nucleotide complementary to the at least one nucleotide; and

permitting the at least one nucleotide on the sprayable material to bond with the second nucleotide on the implant, thereby binding the implant to the sprayable material.

2. The method of claim 1, wherein the sprayable material comprises a core selected from the group consisting of polyalkylene oxides, polyvinyl alcohol, poly(vinyl pyrrolidinone), poly(amino acids), poly(saccharides), hyaluronic acid, proteins, and combinations thereof.

3. The method of claim 1, wherein the at least one functional group capable of binding to tissue is selected from the group consisting of isocyanates, N-hydroxy succinimides, cyanoacrylates, aldehydes, and combinations thereof.

4. The method of claim 1, wherein the nucleotides on the sprayable material and the implant are selected from the group consisting of cytosine, guanine, adenine, thymine, uracil, and combinations thereof.

5. The method of claim 1, wherein the implant comprises a mesh.

6. The method of claim 5, wherein the mesh comprises a polymeric material having a glass transition temperature from about 40°

C. to about 60°

C.

7. The method of claim 6, wherein the mesh possesses a surface feature selected from the group consisting of dimples, grains, grooves, folds, textures, wrinkles, and combinations thereof, that are introduced into the mesh prior to cooling the polymeric material below its glass transition temperature.

8. The method of claim 6, further comprising locally heating the mesh to a temperature above the glass transition temperature of the polymeric material after applying the implant to the sprayable material.

9. The method of claim 5, wherein the mesh comprises a polymeric material having a glass transition temperature from about 25°

C. to about 37°

C.

10. The method of claim 9, wherein the mesh possesses a surface feature selected from the group consisting of dimples, grains, grooves, folds, textures, wrinkles, and combinations thereof, that are introduced into the mesh prior to cooling the polymeric material below its glass transition temperature.

11. The method of claim 10, wherein the introduction of the mesh into the body warms the mesh to a temperature above its glass transition temperature, so that the polymeric material softens and becomes smoother.

12. The method of claim 5, wherein the mesh comprises a shape memory material having a glass transition temperature from about 40°

C. to about 60°

C.

13. The method of claim 12, wherein the mesh possesses a surface feature selected from the group consisting of dimples, grains, grooves, folds, textures, wrinkles, and combinations thereof, that are introduced into the mesh prior to cooling the polymeric material below its glass transition temperature.

14. The method of claim 12, further comprising locally heating the implant in the body to a temperature above its glass transition temperature, at which point the material softens and becomes smooth.

15. The method of claim 5, wherein at least one side of the surgical mesh may be covered with functional groups permitting hydrogen bonding.

16. The method of claim 5, wherein the functional groups comprise a coating on the mesh present in an amount from about 10% to about 100% of the area of the mesh.

17. The method of claim 5, wherein the functional groups comprise a coating in an amount of from about 0.1% to about 20% by weight of the total weight of the mesh.

18. The method of claim 1, wherein the implant further comprises a bioactive agent.