METHODS AND SYSTEM FOR PERFORMING REMOTE ISCHEMIC PRECONDITIONING

• US 20120277789A1
• Filed: 07/06/2012
• Published: 11/01/2012
• Est. Priority Date: 12/06/2006
• Status: Active Grant

• Current Assignee: Hospital For SICK Children
• Original Assignee: Hospital For SICK Children
• Inventors: Caldarone, Christopher, Redington, Andrew
• Granted Patent: US 9,119,761 B2
• Time in Patent Office: Days
• US Class Current: 606/202
• CPC Class Codes: A61B 17/132 Tourniquets sphygmomanometer A61B5/022
• CPC Class Codes: A61B 17/135 inflatable for measuring blood pressure A61B5/022; inflatable pressure pads A61F5/34
• CPC Class Codes: A61B 17/1355 Automated control means therefor
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/02233 Occluders specially adapted therefor tourniquets A61B17/132
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2201/5007 computer controlled
• CPC Class Codes: A61H 2201/5071 Pressure sensors
• CPC Class Codes: A61H 2201/5082 Temperature sensors
• CPC Class Codes: A61H 2230/30 Blood pressure A61H2230/04 takes precedence
• CPC Class Codes: A61H 9/0078 with intermittent or alternately inflated bladders or cuffs mattresses for preventing bed-sores with alternated pressurized chambers A61G7/05776
• CPC Class Codes: A61H 9/0092 Cuffs therefor

Abstract

A system for remote ischemic preconditioning that includes a cuff, and actuator, and a controller that operates the actuator according to a treatment protocol. The treatment protocol includes a plurality of treatment cycles that each comprise cuff actuation, an ischemic duration, cuff release, and a reperfusion duration.

Claims

1-22. -22. (canceled)

23. An automatic device for remote ischemic preconditioning treatment, the device comprising:

a cuff configured to retract about a limb of a subject,

a controller detachably connected to said cuff, said controller being configured to periodically;

inflate said cuff to a cuff pressure at or above a limb occlusion pressure of the subject,

maintain said cuff pressure at or above said limb occlusion pressure for a period of at least about one minute, and

deflate said cuff,

wherein said cuff is further configured to be retained about said limb and deliver said remote ischemic preconditioning treatment.

24. The device as in claim 23, wherein said controller is connected to an outer side of said cuff over said limb.

25. The device as in claim 24, wherein said controller is connected to an inflatable portion of said cuff and oriented to face a user.

26. The device as in claim 23, wherein said controller is sufficiently powered for at least two remote ischemic preconditioning treatments.

27. An automatic device for remote ischemic preconditioning treatment, the device comprising:

a cuff configured to retract about a limb of a subject,

a controller detachably connected to an outer side of said cuff over said limb, said controller being configured to periodically;

inflate said cuff to a cuff pressure at or above a limb occlusion pressure of the subject,

maintain said cuff pressure at or above said limb occlusion pressure for a period of at least about one minute, and

deflate said cuff,

wherein after initial activation by a user, said controller is further configured to conduct and complete said entire treatment without further user input.

28. The device as in claim 27, wherein said initial activation is a single user input.

29. The device as in claim 27, wherein said controller is further configured for automatic hemodynamic surveillance of the subject during said remote ischemic preconditioning treatment.

30. The device as in claim 29, wherein said hemodynamic surveillance is based on measuring pressure in said cuff.

31. The device as in claim 30, wherein said controller is further configured to detect systolic blood pressure of said subject.

32. The device as in claim 31, wherein said controller is further configured to detect systolic blood pressure of said subject at least once during maintaining said cuff pressure at or above said limb occlusion pressure for said period of at least about one minute.

33. A device for remote ischemic preconditioning, the device comprising:

a cuff sized to retract about a limb of a subject,

a controller connected to said cuff, said controller configured to inflate and deflate said cuff according to a remote ischemic preconditioning treatment protocol, said treatment protocol including a plurality of treatment cycles, each of said treatment cycles comprising;

inflating said cuff to a cuff pressure at or above a limb occlusion pressure of the subject,

maintaining said cuff pressure at or above said limb occlusion pressure for a period of at least about one minute, and

deflating said cuff,

wherein during maintaining said cuff pressure at or above said limb occlusion pressure, said controller is further configured to vary said cuff pressure above said limb occlusion pressure at least once during at least one of said treatment cycles.

34. The device as in claim 33, wherein said controller is further configured to detect a systolic blood pressure of the subject during varying of said cuff pressure.

35. The device as in claim 34, wherein said controller is further configured to inflate said cuff pressure at or above a previously recorded systolic blood pressure during varying of said cuff pressure.

36. The device as in claim 35, wherein said controller is further configured to determine a diastolic pressure of the subject, whereby said subject is under continuous hemodynamic surveillance throughout said ischemic preconditioning treatment.