System, Device and Method for Preparing Tracers and Transferring Materials During Radiosynthesis

• US 20120283490A1
• Filed: 04/12/2012
• Published: 11/08/2012
• Est. Priority Date: 04/08/2010
• Status: Active Grant

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Inventors: Gangadharmath, Umesh B., Walsh, Joseph C., Kolb, Hartmuth C., Elizarov, Arkadij M., Rodriguez, Ricardo, Ball, Carroll Edward
• Granted Patent: US 10,639,608 B2
• Time in Patent Office: Days
• US Class Current: 570/153
• CPC Class Codes: A61K 51/0455 having six-membered rings with one nitrogen as the only ring hetero atom
• CPC Class Codes: A61K 51/08 Peptides, e.g. proteins , carriers being peptides, polyamino acids, proteins
• CPC Class Codes: A61K 51/082 the peptide being a RGD-containing peptide
• CPC Class Codes: B01J 19/004 Multifunctional apparatus for automatic manufacturing of various chemical products sequential reactions B01J19/0046
• CPC Class Codes: B01J 4/008 Feed or outlet control devices
• CPC Class Codes: C07B 59/00 Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
• CPC Class Codes: Y10T 137/86035 Combined with fluid receiver

Abstract

A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.

Claims

1. A system for transferring chemical solutions, the system comprising:

a primary container;

a secondary container;

a first line in communication with the primary container and the secondary container, the first line configured to facilitate the flow of gas and/or liquid between the primary container and the secondary container;

a valve upstream of the secondary container and downstream of the primary container, the valve configured to regulate flow within the first line;

a second line in communication with the secondary container; and

a pressure source in communication with the primary container, the pressure source configured to drive gas and/or liquid to the secondary container via the first line;

wherein the first line and the second line are configured to move within the secondary container.

2. The system of claim 1, wherein the second line moves independently of the first line.

3. The system of claim 1, wherein the secondary container is in communication with an HPLC load vial via the second line.

4. The system of claim 1, wherein the system is configured to synthesize radiolabeled tracers.

5. The system of claim 1, wherein the first line and the second line are configured to move toward and away from a chemical solution when the chemical solution is in the secondary container.

6. An apparatus for transferring chemical solutions, the apparatus comprising:

a container configured to contain chemical reagents, reaction intermediates and/or reaction products;

a first line in communication with the container, the first line configured to deliver the chemical reagents, reaction intermediates and/or reaction products to the container;

a second line in communication with the container,

wherein the first line and second line are configured to move toward and away from the bottom of the container.

7. The apparatus of claim 6, further comprising a pneumatic device coupled to the first line and to the second line, the pneumatic device configured to move the first line and the second line.

8. The apparatus of claim 6, wherein the first line and the second line move substantially vertically with respect to a ground plane.

9. A method of transferring chemical solutions, the method comprising:

providing a source of chemical reagents, reaction intermediates and/or products;

providing a container;

providing a pressure source configured to move chemical reagents, reaction intermediates and/or products into the container;

providing a first line in communication with the source of chemical reagents, reaction intermediates and/or products and the container;

providing a second line in communication with the container,

wherein the first line and the second line are configured to move relative to the container,

positioning the first line so that it interacts with chemical reagents, reaction intermediates and/or products when the chemical reagents, reaction intermediates, and/or products are introduced into the container;

positioning the second line so that it is excluded from interacting with the chemical reagents, reaction intermediates and/or products when the chemical reagents, reaction intermediates, and/or products are introduced into the container;

transferring the chemical reagents, reaction intermediates and/or products to the container through the first line, via pressure from the pressure source, such that the first line is in contact with the chemical reagents, reaction intermediates and/or products and the second line is out of contact with the chemical reagents, reaction intermediates and/or products;

moving the first line out of contact with the chemical reagents, reaction intermediates and/or products; and

moving the second line in contact with the chemical reagents, reaction intermediates and/or products.

10. The method of claim 9, further comprising closing the valve after the transferring step.

11. A system for synthesizing a tracer, the system comprising:

a source of a solution comprising a radionuclide;

a first container comprising a tracer precursor, the first container in communication with the source of solution comprising radionuclide;

a second container in communication with the first container, the second container configured to store the tracer; and

a valve downstream of the source of solution comprising radionuclide and upstream of the first container.

12. The system of claim 11, further comprising an apparatus configured to separate the radionuclide from the solution, wherein the apparatus is disposed downstream of the source of solution comprising a radionuclide and upstream of the first container.

13. The system of claim 12, further comprising a third container in communication with the first container, wherein the third container is disposed upstream of the apparatus configured to separate the radionuclide from the solution.

14. The system of claim 13, wherein the third container is configured to comprise an eluting solvent configured to elute radionuclide from the apparatus configured to separate the radionuclide from the solution.

15. The system of claim 11, further comprising a gas source in communication with the third container, wherein the gas source is configured to push contents in the three containers toward the first container.

16. The system of claim 11, further comprising an apparatus for transferring chemical solutions, the apparatus comprising:

a first line in communication with the first container, the first line configured to deliver chemical reagents, reaction intermediates and/or reaction products to the first container; and

a second line in communication with the first container,

wherein the first line and second line are configured to move toward and away from the bottom of the first container.

17. The system of claim 11, wherein at least one component is disposable.

18. A system for synthesizing a tracer, the system comprising:

a source of a solution comprising a radionuclide;

a first container comprising a tracer precursor, the first container in communication with the source of solution comprising radionuclide;

an apparatus configured to separate the radionuclide from the solution, the apparatus being disposed downstream of the source of solution comprising radionuclide and upstream of the first container; and

a source of eluting solvent configured to elute radionuclide separated by the apparatus configured to separate the radionuclide from the solution.

19. The system of claim 18, wherein the first container comprises a tracer precursor.

20. The system of claim 18, further comprising an apparatus for transferring chemical solution, the apparatus comprising:

a first line in communication with the first container, the first line configured to deliver chemical reagents, reaction intermediates and/or reaction products to the first container; and

a second line in communication with the first container,

wherein the first line and second line are configured to move toward and away from the bottom of the first container.

21. A method for synthesizing an ¹⁸F-labeled probe comprising:

a step of eluting an amount of ¹⁸F with a first solvent which includes a predetermined amount of water and at least one organic solvent, wherein the ¹⁸F elutes as an ¹⁸F solution; and

a step of using the ¹⁸F solution to perform ¹⁸F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the ¹⁸F-labeled probe,

wherein drying the ¹⁸F is excluded starting from a time when the eluting step is performed and ending at a time when the ¹⁸F-labeling step is performed.