DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE

• US 20120283648A1
• Filed: 09/29/2010
• Published: 11/08/2012
• Est. Priority Date: 09/30/2009
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Veasey, Robert, Bilton, Simon Lewis, Jones, Christopher, Kouyoumjian, Garen, MacDonald, Catherine Anne
• Granted Patent: US 9,375,534 B2
• Time in Patent Office: Days
• US Class Current: 604/207
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2005/3142 Modular constructions, e.g. supplied in separate pieces to be assembled by end-user
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31555 by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31558 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

A first output member is rotatable around an axis relatively to the body. A second output member is movable relatively to the body along the axis. The first output member and the second output member are rotationally coupled. A drive feature is provided to generate a rotation of the first output member. A part which is removable from and attachable to the body is provided so that the first output member is unidirectionally rotationally coupled with the drive feature when the part is attached to the body.

Claims

1-15. -15. (canceled)

16. Drive mechanism for a drug delivery device, comprising:

a body having a distal end and a proximal end, which are spaced apart in the direction of an axis,

a first output member arranged within the body, the first output member being rotatable around the axis relatively to the body,

a second output member arranged within the body along the axis, the second output member being movable relatively to the body along the axis,

the first output member and the second output member being rotationally coupled, and a drive feature that is provided to generate a rotation of the first output member,

characterized in that

the device further comprises a removable and attachable part, which is removable from and attachable to the body, the first output member being unidirectionally rotationally coupled with the drive feature when the part is attached to the body, so that the first output member is rotatable in one direction,

a resilient element,

the removable and attachable part restraining the resilient element when the part is attached to the body, and

the resilient element removing the unidirectional rotational coupling when the removable and attachable part is removed from the body, so that the first output member is rotatable in an opposite direction.

17. The drive mechanism according to claim 16, wherein the first output member is an output sleeve, and the second output member is an output shaft.

18. The drive mechanism according to claim 16, wherein the removable and attachable part is a cartridge holder provided at the distal end of the body.

19. The drive mechanism according to claim 16, further comprising a pinion member rotationally coupling the first output member and the drive feature.

20. The drive mechanism according to claim 19, further comprising:

a pawl member allowing a rotation of the first output member in only one direction when the removable and attachable part is attached to the body, and allowing a rotation of the first output member in an opposite direction when the removable and attachable part is removed from the body.

21. The drive mechanism according to claim 19, further comprising:

the pinion member having notches,

the pawl member being a hinged tongue or a resilient or resiliently mounted cantilever,

the pawl member having a tip or edge that engages the notches, thus preventing rotation of the pinion member in one direction, and

the pawl member being permanently disengaged from the notches when the removable and attachable part is removed from the body.

22. The drive mechanism according to claim 19, further comprising:

a first input member arranged within the body parallel to the axis along a further axis (5), the first input member being movable relatively to the body along the further axis,

a second input member arranged within the body, the second input member being rotatable around the further axis relatively to the body,

the first input member and the second input member being coupled by a screw thread, and

a clutch rotationally locking the second input member with the pinion member when a load is exerted on the second input member in the distal direction, and not locking the second input member with the pinion member when no load is exerted on the second input member in the distal direction.

23. The drive mechanism according to claim 22, wherein a shift of the first input member in the distal direction generates a rotation of the second input member, the rotation of the second input member generates a rotation of the first output member, and the rotation of the first output member generates a shift of the second output member in the distal direction.

24. The drive mechanism according to claim 22, wherein a set operation is performed by shifting the first input member in the proximal direction, while the second input member is not locked with the pinion member.

25. The drive mechanism according to claim 22, wherein a reset operation is performed, after the removable and attachable part has been removed from the body, by shifting the second output member in the proximal direction.

26. The drive mechanism according to claim 22, further comprising:

a last-dose nut arranged within the body, the last-dose nut being movable relatively to the body along the further axis,

the last-dose nut being coupled with the second input member by a further screw thread and being rotationally coupled with the first output member,

the second input member rotating relatively to the last-dose nut when the first input member is shifted in the proximal direction as the second input member is not locked with the pinion member and consequently not locked to the first output member, thus generating a movement of the last-dose nut in the distal or proximal direction by means of the further screw thread, and

a protruding part of the second input member, the protruding part limiting the movement of the last-dose nut in the distal or proximal direction.

27. The drive mechanism according to claim 26, wherein

a reset operation is performed by shifting the second output member in the proximal direction, the first output member rotating according to the rotational coupling to the second output member,

the rotation of the first output member generates a rotation of the last-dose nut, and

the rotation of the last-dose nut relatively to the second input member generates a movement of the last-dose nut in the distal or proximal direction.

28. The drive mechanism according to claim 27, wherein

the first output member and the second output member are coupled by a screw thread,

the screw thread coupling the output members and the further screw thread are provided with pitches that are adapted to the rotational coupling of the last-dose nut with the first output member in such a manner as to produce a movement of the last-dose nut to a start position during a reset operation, the start position having a defined distance from the protruding part of the second input member.

29. The drive mechanism according to claim 16, further comprising:

a groove or track of the body locking the second output member rotationally to the body while allowing a shift of the second output member along the axis.