Method for Assembling a Drug Delivery Device, Assembly for a Drug Delivery Device and Piston Rod for a Drug Delivery Device

• US 20120283662A1
• Filed: 09/29/2010
• Published: 11/08/2012
• Est. Priority Date: 09/30/2009
• Status: Abandoned Application

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: MacDonald, Catherine Anne, Veasey, Robert, Plumptre, David, Jones, Christopher, Kouyoumjian, Garen
• Application Number:
  US13/496,701
• Publication Number:
  US 20120283662A1
• Time in Patent Office: Days
• US Class Current: 604/236
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/3121 via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/31515 Connection of piston with piston rod
• CPC Class Codes: A61M 5/31555 by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button

Abstract

A method for assembling a drug delivery device comprising a body (2) retaining a piston rod (3) and a cartridge (5) retaining a bung (6) and holding a drug, said body (2) having a distal end (11) and a proximal end (12),

comprises the following steps:

• A) Providing the cartridge (5) and the body (2) retaining the piston rod (3), wherein the piston rod (3) is plastically deformable, at least a part of said plastically deformable piston rod being manufactured from a plastically deformable material,
• B) Applying a force on the piston rod (3), at least a part of the piston rod (3) being in a state that allows plastic deformation, so that the piston rod (3) is plastically deformed and an element of the piston rod (3) abuts the bung (6),
• C) Applying conditions in order to bring the plastically deformed piston rod (3) of step B) into an altered state wherein no further plastic deformation takes place,
• D) Securing the cartridge (5) to the body (2).

Claims

1. A method for assembling a drug delivery device comprising a body retaining a piston rod and a cartridge retaining a bung and holding a drug, said body having a distal end and a proximal end,

comprising the following steps:

A) Providing the cartridge and the body retaining the piston rod, wherein the piston rod is plastically deformable, at least a part of said plastically deformable piston rod being manufactured from a plastically deformable material,

B) Applying a force on the piston rod, at least a part of the piston rod being in a state that allows plastic deformation, so that the piston rod is plastically deformed and an element of the piston rod abuts the bung,

C) Applying conditions in order to bring the plastically deformed piston rod of step B) into an altered state wherein no further plastic deformation takes place

D) Securing the cartridge to the body.

2. The method according to claim 1, wherein in step B) the applied force results from a movement of the piston rod in distal direction, or a movement of a component being fixed to the piston rod in distal direction, or a movement of the cartridge in proximal direction, or a movement of a component being fixed to the cartridge in proximal direction.

3. The method according to claim 1, wherein in step B) the piston rod is plastically deformed during attachment of the cartridge to the body.

4. The method according to claim 1, wherein between step A) and step B) the following step is carried out:

E) the plastically deformable material is brought into a plastically deformable state of matter by heating.

5. The method according to claim 1, wherein the plastically deformable material of step A) comprises a thermoplastic polymer or consists of a thermoplastic polymer.

6. The method according to claim 1, wherein the altered state of matter of step C) is obtained by cooling or by effecting a chemical reaction of the plastically deformable material.

7. The method according to claim 4, wherein the plastically deformable material comprises an inductively heatable compound and wherein in step E) the plastically deformable material is inductively heated.

8. The method according to claim 1, wherein the piston rod of step A) comprises a first element comprising the plastically deformable material and a second element at least a part of which is manufactured from an inductively heatable material, wherein the first element abuts the second element, and wherein in step E) the plastically deformable material is inductively heated.

11. The method according to claim 1, wherein the distance defining component is a cartridge holder.

14. The assembly obtained by the method of claim 1.

9. A method for assembling a drug delivery device comprising a body retaining a piston rod and a cartridge retaining a bung and holding a drug, said body having a distal end and a proximal end,

comprising the following steps:

A′

) Providing a component defining the distance between the proximal face of the bung and the proximal end of the piston rod,

B′

) Engaging the cartridge and the distance defining component,

C′

) Arranging the cartridge in its most distal position with respect to the distance defining component and determining a distance between the proximal face of the bung and the proximal end of the distance defining component,

D′

) Calculating the gap between the proximal face of the bung and the distal end of the piston rod from the distance determined in step C′

),

E′

) Adjusting the length of the piston rod,

F′

) Securing the cartridge to the body.

10. The method according to claim 9, wherein the piston rod is plastically deformable.

12. A piston rod contained in an assembly for a drug delivery device having a distal end and a proximal end which are spaced apart in the direction of an axis, said piston rod comprising a predetermined area of weakness, which is deformable upon application of a force in the direction of the axis with respect to the piston rod.

13. An assembly for a drug delivery device having a distal end and a proximal end, comprising

a body retaining a piston rod,

a cartridge retaining a bung,

wherein the cartridge is secured to the body

and wherein the piston rod abuts the proximal face of the bung, the piston rod comprising a plastically deformed area, at least a part of said plastically deformed piston rod being obtained from a plastically deformable material.

15. The assembly according to claim 13, wherein the plastically deformed area is obtained by deformation of a predetermined area of weakness.

16. A drug delivery device comprising the assembly according to claim 13.