METHODS AND PROCEDURES FOR LIGAMENT REPAIR

• US 20120283831A1
• Filed: 05/01/2012
• Published: 11/08/2012
• Est. Priority Date: 01/25/2006
• Status: Active Grant

• Current Assignee: Children's Medical Center Corporation
• Original Assignee: Children's Medical Center Corporation
• Inventors: Murray, Martha M.
• Granted Patent: US 10,786,232 B2
• Time in Patent Office: Days
• US Class Current: 623/13.14
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/0469 Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
• CPC Class Codes: A61B 17/1146 of tendons
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/0414 having a suture-receiving opening, e.g. lateral opening lateral eyelet for attaching suture to needle A61B2017/06019
• CPC Class Codes: A61B 2017/044 with a threaded shaft, e.g. screws
• CPC Class Codes: A61B 2017/0458 Longitudinal through hole, e.g. suture blocked by a distal suture knot
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61F 2002/0888 Anchor in or on a blind hole or on the bone surface without formation of a tunnel
• CPC Class Codes: A61L 17/12 Homopolymers or copolymers of glycolic acid or lactic acid
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 27/22 Polypeptides or derivatives thereof , e.g. degradation products
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges

Abstract

Methods and devices for the repair of a ruptured ligament using a scaffold device are provided. Aspects of the invention, may include a scaffold attached by a suture to an anchor. In aspects of the invention, the anchor may be secured to a bone near or at the repair site.

Claims

1. A construct for repair or augmentation of a tissue exposed to synovial fluid comprising a compressible porous support scaffold configured for repair or augmentation of the tissue, wherein the scaffold allows cell ingrowth.

2. The construct of claim 1, wherein the tissue is a ligament, tendon, meniscus, cartilage, labrum or muscle.

3. The construct of claim 2, wherein the ligament is an ACL.

4. The construct of claim 1, wherein the scaffold is expandable.

5. The construct of claim 1, further comprising a suture.

6. The construct of claim 5, wherein the suture is bioabsorbable.

7. The construct of claim 1, further comprising an anchor.

8. The construct of claim 7, wherein the anchor is selected from the group consisting of a screw, a barb, a helical anchor, a staple, a clip, a snap, and a rivet.

9. The construct of claim 1, further comprising a bone insertion device.

10. The construct of claim 1, wherein the scaffold comprises a therapeutic agent.

11. The construct of claim 10, wherein the therapeutic agent is selected from the group consisting of hormones, cytokines, growth factors, clotting factors, anti-protease proteins, angiogenic proteins, antiangiogenic proteins, bone morphogenic proteins, osteoinductive factor, fibronectin, endothelial cell growth factor, cementum attachment extracts, ketanserin, human growth hormone, animal growth hormones, epidermal growth factor, interleukin-1, human alpha thrombin, transforming growth factor, insulin-like growth factor, platelet derived growth factors, fibroblast growth factors, and periodontal ligament chemotactic factors.

12. The construct of claim 1, wherein the scaffold comprises a clotting factor.

13. The construct of claim 1, wherein the scaffold comprises platelets or platelet rich plasma.

14. The construct of claim 1, wherein the scaffold comprises collagen.

15. The construct of claim 1, wherein the scaffold is a sponge.

16. The construct of claim 1, wherein the scaffold is tubular, semi-tubular, or cylindrical.

17. The construct of claim 1, wherein the scaffold is an amorphous shape that conforms to the shape of a repair space.

18. The construct of claim 1, comprising the scaffold, at least one bone insertion device and at least one suture.

19. The construct of claim 18, comprising a platelet and a clotting factor in the scaffold.

20. The construct of claim 1, wherein the construct further comprises xenograft tissue, allograft tissue, or autograft tissue.

21. A kit comprising the construct of claim 1, and a scaffold, suture, and a bone insertion device.

22. A kit comprising the construct of claim 1, a scaffold and platelets or means for obtaining platelets from a patient.

23. The kit of claim 21, further comprising a therapeutic agent.

24. The kit of claim 22, further comprising a therapeutic agent.

25. The kit of claim 23, wherein the therapeutic agent is a clotting factor.

26. The kit of claim 24, wherein the therapeutic agent is a clotting factor.