Please download the dossier by clicking on the dossier button x
×

PEPTIDE OLIGONUCLEOTIDE CONJUGATES

  • US 20120289457A1
  • Filed: 11/17/2011
  • Published: 11/15/2012
  • Est. Priority Date: 05/05/2011
  • Status: Active Grant
First Claim
Patent Images

1. A conjugate comprising:

  • (a) a carrier peptide comprising amino acid subunits; and

    (b) a nucleic acid analogue comprising a substantially uncharged backbone and a targeting base sequence for sequence-specific binding to a target nucleic acid;

    wherein;

    two or more of the amino acid subunits are positively charged amino acids, the carrier peptide comprises a glycine (G) or proline (P) amino acid subunit at a carboxy terminus of the carrier peptide, no more than seven contiguous amino acid subunits are arginine, and the carrier peptide is covalently attached to the nucleic acid analogue.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×