PACKAGE FOR IMPROVED TREATMENT OF CONDITIONS

• US 20120289534A1
• Filed: 05/11/2012
• Published: 11/15/2012
• Est. Priority Date: 05/11/2011
• Status: Abandoned Application

• Current Assignee: Kirax Corporation
• Original Assignee: Kirax Corporation
• Inventors: PERGOLIZZI, Joseph, Chopra, Maninder, Muniz, Edmundo, Flanzraich, Neil
• Application Number:
  US13/470,150
• Publication Number:
  US 20120289534A1
• Time in Patent Office: Days
• US Class Current: 514/282
• CPC Class Codes: A61J 1/035 Blister-type containers blisters in general B65D75/36
• CPC Class Codes: A61J 7/04 Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/08 for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention provides an improved package from the administration of active ingredients. The present invention provides a package comprising: a standard portion comprising one or more active ingredients in a plurality of different potencies, and a rescue portion comprising one or more same or different active ingredients. The package may be optionally be used with a patient assessment module. The present invention also provides a kit comprising: a package comprising a standard portion comprising one or more active ingredients in a plurality of different potencies, and a patient assessment module comprising instructions for administration of the standard portion. The package may optionally further comprise a rescue portion.

Claims

1. A package comprising:

a standard portion comprising one or more active ingredients, and

a rescue portion comprising one or more same or different active ingredients.

2. The package of claim 1, wherein the standard portion comprises a plurality of sections comprising a plurality of different potencies of one or more active ingredients.

3. The package of claim 1, wherein each of the plurality of sections comprises an amount of one or more active ingredients to be administered over a predetermined time period.

4. The package of claim 3, wherein plurality of sections is arranged in decreasing potency.

5. The package of claim 4, wherein the plurality of sections is arranged in sequentially decreasing potency.

6. The package of claim 3, wherein the predetermined time period is selected from the group consisting of one day, one week, one month, and one year.

7. The package of claim 1, wherein the package further comprises placebo unit dosage forms.

8. The package of claim 1, wherein the standard portion and the rescue portion both comprises one or more of the same active ingredients.

9. The package of claim 1, wherein the one or more active ingredients comprises an agent selected from the group consisting of:

analgesics, antimigraine medications, H₂ receptor antagonists, proton pump inhibitors, sedatives, opioid receptor antagonists, nicotine replacement medications, antiemetics, anxiolytics, and antidiarrheal medications.

10. The package of claim 1, wherein the one or more active ingredients comprises opioids.

11. The package of claim 1, wherein the package comprises two or more active ingredients, wherein one of the active ingredients enhances the activity, provides a synergistic effect, or decreases the side effects of another active ingredient.

12. A kit comprising:

a package comprising a standard portion comprising a plurality of sections comprising a plurality of different potencies of one or more active ingredients, and

a patient assessment module comprising a device configured for subjective assessment of the patient'"'"'s condition and optionally correlated to subsequent administration of one or more active ingredients.

13. The kit of claim 12, wherein the patient assessment module comprises a component selected from the group consisting of:

numerical rating scales, visual analog scales, and charts.

14. The kit of claim 12, wherein the package further comprises a rescue portion comprising one or more same or different active ingredients.

15. The kit of claim 14, wherein the patient assessment module comprises a device configured for subjective assessment of the patient'"'"'s condition and optionally correlated to subsequent administration of one or more active ingredients in the standard portion, the rescue portion, or both the standard portion and the rescue portion.

16. The kit of claim 12, wherein each of the plurality of sections sections comprises an amount of one or more active ingredients to be administered over a predetermined time period.

17. The kit of claim 12, wherein the plurality of sections are arranged in decreasing potency.

18. The kit of claim 12, wherein the plurality of sections are arranged in sequentially decreasing potency.

19. The kit of claim 16, wherein the predetermined time period is selected from the group consisting of one day, one week, one month, and one year.

20. The kit of claim 14, wherein the standard portion and the rescue portion both comprises one or more of the same active ingredients.

21. The kit of claim 12, wherein the one or more active ingredients comprises an agent selected from the group consisting of:

analgesics, antimigraine medications, H₂ receptor antagonists, proton pump inhibitors, sedatives, opioid receptor antagonists, nicotine replacement medications, antiemetics, anxiolytics, and antidiarrheal medications.

22. The kit of claim 12, wherein the one or more active ingredients comprises an opioid.

23. The kit of claim 12, wherein the package comprises two or more active ingredients, wherein one of the active ingredients enhances the activity, provides a synergistic effect, or decreases the side effects of another active ingredient.

24. The kit of claim 12, wherein the package and the patient assessment module are configured together as one piece.

25. A package comprising:

a standard portion comprising a plurality of sections comprising unit dosage forms comprising oxycodone and acetaminophen, wherein each of the plurality of sections comprises an amount of oxycodone and acetaminophen to be administered over a period of one day,

wherein the standard portion comprises;

a first section comprising oxycodone 45 mg and acetaminophen 1,950 mg;

a second section comprising oxycodone 37.5 mg and acetaminophen 1,625 mg;

a third section comprising oxycodone 30 mg and acetaminophen 1,300 mg;

a fourth section comprising oxycodone 30 mg and acetaminophen 1,300 mg;

a fifth section comprising oxycodone 22.5 mg and acetaminophen 975 mg;

a sixth section comprising oxycodone 22.5 mg and acetaminophen 975 mg;

a seventh section comprising oxycodone 22.5 mg and acetaminophen 975 mg; and

an eighth section comprising oxycodone 22.5 mg and acetaminophen 975 mg.

26. The package of claim 25, wherein the package further comprises a rescue portion comprising unit dosage forms comprising oxycodone 52.5 mg and acetaminophen 2,275 mg.

27. A package comprising:

a standard portion comprising a plurality of sections comprising unit dosage forms comprising hydrocodone and acetaminophen, wherein each of the plurality of sections comprises an amount of oxycodone and acetaminophen to be administered over a period of one day,

wherein the standard portion comprises;

a first section comprising hydrocodone 30 mg and acetaminophen 3,000 mg;

a second section comprising hydrocodone 25 mg and acetaminophen 2,500 mg;

a third section comprising hydrocodone 20 mg and acetaminophen 2,000 mg;

a fourth section comprising hydrocodone 20 mg and acetaminophen 2,000 mg;

a fifth section comprising hydrocodone 15 mg and acetaminophen 1,500 mg;

a sixth section comprising hydrocodone 15 mg and acetaminophen 1,500 mg;

a seventh section comprising hydrocodone 15 mg and acetaminophen 1,500 mg; and

an eighth section comprising hydrocodone 15 mg and acetaminophen 1,500 mg.

28. The package of claim 27, wherein the package further comprises a rescue portion comprising unit dosage forms comprising hydrocodone 35 mg and acetaminophen 3,500 mg.