EMBOLIC DEVICES
First Claim
Patent Images
1. An expansile device for implantation comprising:
- a polymeric filament including a poly (ethylene glycol) 10,000 macromer;
an ethylenically unsaturated monomer; and
at least one visualization element,wherein the expansile device includes no metal support members.
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Abstract
Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations of the vasculature with radiopaque hydrogel filaments with delayed controlled rates of expansion. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
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Citations
22 Claims
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1. An expansile device for implantation comprising:
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a polymeric filament including a poly (ethylene glycol) 10,000 macromer;
an ethylenically unsaturated monomer; and
at least one visualization element,wherein the expansile device includes no metal support members. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of forming an environmentally responsive hydrogel comprising:
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a. preparing a polymerization solution comprising a poly (ethylene glycol) macromer;
at least one ethylenically unsaturated monomer; and
at least one visualization element in a solvent;b. polymerizing the polymerization solution to create a polymerized hydrogel; and c. treating said polymerized hydrogel in a non-physiological pH for a predetermined amount of time thereby creating an environmentally responsive hydrogel. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A hydrogel filament consisting essentially of about 25% w/w poly(ethylene glycol) 10,000 diacrylamide, about 11% w/w sodium acrylate, about 1% w/w N,N-methylenebisacrylamide, about 63% barium sulfate, and about <
- 1% 2,2′
-azobis(2-methylpropionaamidine)dihydrochloride.
- 1% 2,2′
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22. A hydrogel filament consisting essentially of about 29% w/w poly(ethylene glycol) 10,000 diacrylamide, about 12% w/w sodium acrylate, about 1% w/w N,N-methylenebisacrylamide, about 58% barium sulfate, and about <
- 1% 2,2′
-azobis(2-methylpropionaamidine)dihydrochloride.
- 1% 2,2′
Specification