PORTABLE HEMOSTASIS ANALYZER

• US 20120294767A1
• Filed: 05/18/2012
• Published: 11/22/2012
• Est. Priority Date: 05/19/2011
• Status: Abandoned Application

• Current Assignee: Hemosonics LLC (Stago International SAS)
• Original Assignee: Hemosonics LLC (Stago International SAS)
• Inventors: Viola, Francesco, Walker, William F.
• Application Number:
  US13/475,347
• Publication Number:
  US 20120294767A1
• Time in Patent Office: Days
• US Class Current: 422/73
• CPC Class Codes: G01N 2291/02466 Biological material, e.g. blood
• CPC Class Codes: G01N 2291/02818 Density, viscosity
• CPC Class Codes: G01N 2291/02827 Elastic parameters, strength or force
• CPC Class Codes: G01N 2291/044 Internal reflections (echoes), e.g. on walls or defects
• CPC Class Codes: G01N 2291/101 one transducer
• CPC Class Codes: G01N 29/024 by measuring propagation velocity or propagation time of acoustic waves
• CPC Class Codes: G01N 29/222 Constructional or flow details for analysing fluids optoacoustic fluid cells G01N29/2425
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors

Abstract

Provided are devices, systems and methods for the use of a portable unit for the evaluation of hemostasis. For example, a portable system for determining a plurality of hemostatic parameters may be included. The system includes a blood sample receptacle, an analyzer and a housing. The blood sample receptacle is configured to hold at least one blood sample. The analyzer is configured to determine at least two hemostatic parameters of the at least one blood sample. The housing is configured to operably couple the blood sample receptacle and the analyzer. The housing is portable and may, for example, have a thickness of 17.5 cm or smaller.

Claims

1. A portable system for determining a plurality of hemostatic parameters, the system comprising:

a. a blood sample receptacle configured to hold at least one blood sample;

b. an analyzer configured to determine at least two hemostatic parameters of the at least one blood sample; and

c. a housing configured to operably couple the blood sample receptacle and the analyzer, the housing having a thickness of 17.5 cm or smaller.

2. A system of claim 1, wherein the hemostatic parameters are determined by measuring changes in viscoelastic properties of the blood sample over time.

3. A system of claim 1, wherein the thickness is a minimum outer dimension of the housing and is 2.65 cm or smaller.

4. A system of claim 1, further comprising a pumping mechanism configured to fill the blood sample receptacle.

5. A system of claim 4, wherein the pumping mechanism comprises a micro-pump, wherein the micro-pump is contained within the housing.

6. A system of claim 5, wherein the micro-pump includes a piezo-actuated component.

7. A system of claim 6, wherein the micro-pump includes a diaphragm.

8. A system of claim 4, wherein the pumping mechanism comprises a manually-operated pump system with at least one check valve.

9. A system of claim 1, further comprising a temperature mechanism configured control a temperature of the blood sample.

10. A system of claim 9, wherein the temperature mechanism includes a heater.

11. A system of claim 10, wherein the temperature mechanism includes a temperature sensor.

29. A system of claim 9, wherein the temperature mechanism is a Peltier device.

30. A system of claim 10, wherein the heater is configured to generate heat for the test chambers and blood samples.

12-24. -24. (canceled)

25. A portable system comprising:

a. a consumable receptacle configured to receive a consumable holding at least one blood sample;

b. a processor configured to compute at least two hemostatic indexes; and

c. a display connected to the sensor and configured to display the at least two hemostatic indexes;

d. wherein the consumable receptacle, processor and display are 10 pounds or less.

26. A system of claim 25, wherein the hemostatic indexes include at least one of a group consisting of a coagulation factor function, a fibrinogen concentration, a fibrinogen function, a platelet function and a fibrinolysis function.

27. A system of claim 25, wherein the system is further configured to correct for environmental vibrations.

31. A system of claim 25, further comprising a temperature mechanism configured to control a temperature of the blood sample.

32. A system of claim 31, wherein the temperature mechanism includes a heater configured to generate heat for the test chambers and blood samples.

28. A system for determining at least one hemostatic parameter, the system comprising:

a. a blood sample receptacle configured to hold at least one blood sample and eliminate an interface between the blood sample and a gas;

b. an analyzer configured to determine the at least one hemostatic parameter of the at least one blood sample; and

c. a housing configured to operably couple the blood sample receptacle and the analyzer, the housing having a thickness of 4.4 cm or smaller.

33. A system of claim 28, further comprising a temperature mechanism configured to control a temperature of the blood sample.