System and Method for Hybrid Radiofrequency Labeling for Magnetic Resonance Imaging

• US 20120296193A1
• Filed: 05/19/2011
• Published: 11/22/2012
• Est. Priority Date: 05/19/2011
• Status: Active Grant

• Current Assignee: Northshore University Healthsystem (Advocate Aurora Health, Inc.)
• Original Assignee: Northshore University Healthsystem (Advocate Aurora Health, Inc.)
• Inventors: Koktzoglou, Ioannis
• Granted Patent: US 10,413,213 B2
• Time in Patent Office: Days
• US Class Current: 600/410
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

A system and method is provided for magnetic resonance angiography (MRA) that includes applying a first labeling pulse sequence to a first labeling region having a first portion of a vasculature of a subject extending through the first labeling region to label spins moving within the first labeling region. A second labeling pulse sequence is applied to a second labeling region having a second portion of a vasculature of the subject extending through the second labeling region to label spins moving within the second labeling region. The first and second labeling pulse sequences include different labeling techniques. An imaging pulse sequence is applied to an imaging region having a third portion of a vasculature of the subject extending through the imaging region that is displaced from the first and second labeling region to acquire imaging data from the spins labeled by the first labeling pulse sequence and the second labeling pulse sequence. An MRA image is reconstructed of at least the third portion of the vasculature of the subject from the medical imaging data.

Claims

1. A method for acquiring a magnetic resonance angiography (MRA) image of a portion of a vasculature of a subject using a magnetic resonance imaging system, the method comprising:

applying a first labeling pulse sequence to a first labeling region having a first portion of a vasculature of a subject extending through the first labeling region to label spins moving within the first labeling region;

applying a second labeling pulse sequence to a second labeling region having a second portion of a vasculature of the subject extending through the second labeling region to label spins moving within the second labeling region, wherein the first and second labeling pulse sequences include different labeling techniques;

applying an imaging pulse sequence to an imaging region having a third portion of a vasculature of the subject extending through the imaging region that is displaced from the first and second labeling region to acquire imaging data from the spins labeled by the first labeling pulse sequence and the second labeling pulse sequence; and

reconstructing an MRA image of at least the third portion of the vasculature of the subject from the medical imaging data.

2. The method of claim 1 wherein the first labeling region and the second labeling region are discontinuously separate.

3. The method of claim 1 wherein the first labeling region and the second labeling region overlap at least partially.

4. The method of claim 1 wherein one of the first labeling pulse sequence or second labeling pulse sequence includes a non-continuous RF labeling technique and at least one of the first labeling pulse sequence and the second labeling pulse sequence includes a substantially continuous RF labeling technique.

5. The method of claim 1 wherein the first labeling region and the second labeling region are located along an upstream portion of vasculature of the subject with respect to the imaging region.

6. The method of claim 5 wherein the first labeling pulse sequence includes a substantially continuous labeling technique and the second labeling pulse sequence includes a non-continuous labeling technique.

7. The method of claim 5 wherein the first labeling pulse sequence includes a non-continuous labeling technique and the second labeling pulse sequence includes a substantially continuous labeling technique.

8. The method of claim 1 further comprising performing a planning study prior to application of the first labeling pulse sequence to determine at least one of anatomical and physiological parameters of the subject with respect to at least one of the first, second, and third portion of the vasculature of the subject.

9. A magnetic resonance imaging (MRI) system comprising:

a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;

a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;

a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data therefrom;

a computer system programmed to;

apply a first labeling pulse sequence to a first labeling region having a first portion of a vasculature of a subject extending through the first labeling region to label spins moving within the first labeling region;

apply a second labeling pulse sequence to a second labeling region having a second portion of a vasculature of the subject extending through the second labeling region to label spins moving within the second labeling region, wherein the first and second labeling pulse sequences include different labeling techniques;

apply an imaging pulse sequence to an imaging region having a third portion of a vasculature of the subject extending through the imaging region that is displaced from the first and second labeling region to acquire imaging data from the spins labeled by the first labeling pulse sequence and the second labeling pulse sequence; and

reconstructing an MRA image of at least the third portion of the vasculature of the subject from the medical imaging data.

10. The system of claim 9 wherein the first labeling region and the second labeling region are discontinuously separate.

11. The method of claim 9 wherein the first labeling region and the second labeling region overlap at least partially.

12. The system of claim 9 wherein one of the first labeling pulse sequence and the second labeling pulse sequence includes a non-continuous RF labeling technique and one of the first labeling pulse sequence and second labeling pulse sequence includes a substantially continuous RF labeling technique.

13. The system of claim 9 wherein the first labeling region and the second labeling region are located along an upstream portion of vasculature of the subject with respect to the imaging region.

14. The system of claim 13 wherein the first labeling pulse sequence includes a substantially continuous labeling technique and the second labeling pulse sequence includes a non-continuous labeling technique.

15. The method of claim 13 wherein the first labeling pulse sequence includes a non-continuous labeling technique and the second labeling pulse sequence includes a substantially continuous labeling technique.

16. The system of claim 9 further comprising performing a planning study prior to application of the first labeling pulse sequence to determine at least one of anatomical and physiological parameters of the subject with respect to at least one of the first, second, and third portion of the vasculature of the subject.