METHOD AND SYSTEM FOR FACILITATING ADJUSTING A CIRCADIAN PACEMAKER

• US 20120296400A1
• Filed: 02/01/2011
• Published: 11/22/2012
• Est. Priority Date: 02/01/2010
• Status: Abandoned Application

• Current Assignee: Rensselaer Polytechnic Institute
• Original Assignee: Rensselaer Polytechnic Institute
• Inventors: Bierman, Andrew, Rea, Mark S., Figueiro, Mariana
• Application Number:
  US13/575,788
• Publication Number:
  US 20120296400A1
• Time in Patent Office: Days
• US Class Current: 607/88
• CPC Class Codes: A61M 2021/0044 by the sight sense
• CPC Class Codes: A61M 21/00 Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/332 Force measuring means
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2230/50 Temperature
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61N 2005/0628 including a radiation sensor
• CPC Class Codes: A61N 2005/0647 the applicator adapted to be worn on the head
• CPC Class Codes: A61N 2005/0648 the light being directed to the eyes
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 2005/0667 Filters
• CPC Class Codes: A61N 5/0618 Psychological treatment

Abstract

A method and system for facilitating adjusting a user'"'"'s circadian pacemaker are provided, including determining a current circadian pacemaker state of the user, as well as potential future states of the user'"'"'s circadian pacemaker. The potential future states are related to a target circadian pacemaker state representing a circadian pacemaker goal for the user. This is accomplished on a state-variable plane using vectors. An optimum potential future state is selected as a basis for constructing a light exposure treatment schedule for the user. A light exposure treatment schedule is then constructed and provided to the user to facilitate taking control of the user'"'"'s circadian pacemaker and manipulating it for benefits such as health and performance benefits.

Claims

1. A method for facilitating adjusting a user'"'"'s circadian pacemaker, the method comprising:

constructing a light exposure treatment schedule to facilitate attaining a circadian pacemaker goal for the user, the constructing comprising;

determining, by a processor, the user'"'"'s current circadian pacemaker state at a time t_c;

ascertaining at least two potential future states of the user'"'"'s circadian pacemaker based on the user'"'"'s current circadian pacemaker state, and wherein the at least two potential future states are ascertained based on different respective potential light exposure conditions applied to the user;

automatically choosing one potential future state of the at least two potential future states for use in constructing the light exposure treatment schedule, the automatically choosing being based on the relation of each potential future state of the at least two potential future states to a target exogenous clock state derived from the circadian pacemaker goal for the user; and

constructing the light exposure treatment schedule based on the chosen one potential future state; and

providing the constructed light exposure treatment schedule to the user to facilitate the user attaining the circadian pacemaker goal.

2. The method of claim 1, wherein the target exogenous clock state comprises a state of an exogenous clock, and wherein the circadian pacemaker goal comprises entraining the user'"'"'s circadian pacemaker to the exogenous clock.

3. The method of claim 2, further comprising plotting the exogenous clock on a state-variable plane.

4. The method of claim 3, wherein the automatically choosing comprises relating the at least two potential future states of the user'"'"'s circadian pacemaker to the target exogenous clock state on the state-variable plane.

5. The method of claim 4, wherein the relating comprises evaluating vector distance between each potential future state and the target exogenous clock state on the state-variable plane, and wherein the automatically choosing further comprises selecting the potential future state having the shortest vector distance between it and the target exogenous clock state.

6. The method of claim 3, wherein the entraining the user'"'"'s circadian pacemaker to the exogenous clock comprises matching, within a predefined amount, the user'"'"'s circadian pacemaker to the exogenous clock on the state-variable plane.

7. The method of claim 1, wherein the at least two potential future states are ascertained for a future time t_f. and wherein the target exogenous clock state comprises a state of an exogenous clock for the future time t_f.

8. The method of claim 1, wherein the circadian pacemaker goal comprises a desired manipulation to the user'"'"'s circadian pacemaker.

9. The method of claim 1, wherein the constructed light exposure treatment schedule comprises a first light exposure treatment schedule, and wherein the method further comprises:

automatically repeating the constructing at some later time t_l to construct a second light exposure treatment schedule, the automatically repeating the constructing at the later time t_l comprising determining the user'"'"'s circadian pacemaker state at the later time t_l; and

dynamically replacing the first light exposure treatment schedule with the second light exposure treatment schedule constructed.

10. The method of claim 9, further comprising updating the circadian pacemaker goal for the user prior to repeating the constructing and the providing the second light exposure treatment schedule.

11. The method of claim 1, further comprising providing by the user one or more constraints on the constructed light exposure treatment schedule, and wherein constructing the light exposure treatment schedule comprises accounting for the one or more constraints.

12. The method of claim 11, wherein the one or more constraints on the constructed light exposure treatment schedule comprise at least one of:

availability of a time for receiving a light exposure treatment, or a light exposure limit.

13. The method of claim 1, wherein determining the user'"'"'s current circadian pacemaker state comprises ascertaining a current level of circadian entrainment of the user, the ascertaining the current level comprising performing phasor analysis on a set of the obtained light exposure data and activity data for the user obtained during a defined interval of time, and wherein the set of obtained light exposure data and activity data comprises measurements of a primary stimulus to the user'"'"'s circadian pacemaker and measurements of an output marker of the user'"'"'s circadian pacemaker, and wherein the output marker comprises at least one of minimum core body temperature, or melatonin onset.

14. A system for facilitating adjusting a user'"'"'s circadian pacemaker, the system comprising:

one or more processors to perform;

constructing a light exposure treatment schedule to facilitate attaining a circadian pacemaker goal for the user, the constructing comprising;

determining the user'"'"'s current circadian pacemaker state at a time t_c;

ascertaining at least two potential future states of the user'"'"'s circadian pacemaker based on the user'"'"'s current circadian pacemaker state, and wherein the at least two potential future states are ascertained based on different respective potential light exposure conditions applied to the user;

automatically choosing one potential future state of the at least two potential future states for use in constructing the light exposure treatment schedule, the automatically choosing being based on the relation of each potential future state of the at least two potential future states to a target exogenous clock state derived from the circadian pacemaker goal for the user; and

constructing the light exposure treatment schedule based on the chosen one potential future state; and

providing the constructed light exposure treatment schedule to the user to facilitate the user attaining the circadian pacemaker goal.

15. The system of claim 14, wherein the target exogenous clock state comprises a state of an exogenous clock, wherein the circadian pacemaker goal comprises entraining the user'"'"'s circadian pacemaker to the exogenous clock, and wherein the one or more processors further perform plotting the exogenous clock on a state-variable plane.

16. The system of claim 14, wherein the automatically choosing comprises relating the at least two potential future states of the user'"'"'s circadian pacemaker to the target exogenous clock state on the state-variable plane, wherein the relating comprises evaluating vector distance between each potential future state and the target exogenous clock state on the state-variable plane, and wherein the automatically choosing further comprises selecting the potential future state having the shortest vector distance between it and the target exogenous clock state.

17. The system of claim 14, wherein the circadian pacemaker goal comprises a desired manipulation to the user'"'"'s circadian pacemaker.

18. The system of claim 15, wherein the constructed light exposure treatment schedule comprises a first light exposure treatment schedule, and wherein the one or more processors further perform:

automatically repeating the constructing at some later time t_l to construct a second light exposure treatment schedule, the automatically repeating the constructing at the later time t_l comprising determining the user'"'"'s circadian pacemaker state at the later time t_l; and

dynamically replacing the first light exposure treatment schedule with the second light exposure treatment schedule constructed.

19. The system of claim 14, wherein the user provides one or more constraints on the constructed light exposure treatment schedule, and wherein the constructing the light exposure treatment schedule comprises accounting for the one or more constraints.

20. The system of claim 19, wherein the one or more constraints on the constructed light exposure treatment schedule comprise at least one of:

availability of a time for receiving a light exposure treatment, or a light exposure limit.