Cortical Interface for Motor Signal Recording and Sensory Signal Stimulation

• US 20120296444A1
• Filed: 05/16/2012
• Published: 11/22/2012
• Est. Priority Date: 05/16/2011
• Status: Active Grant

• Current Assignee: Cortigent Incorporated
• Original Assignee: Second Sight Medical Products, Inc.
• Inventors: Greenberg, Robert J., Zhou, David Daomin, Talbot, Neil Hamilton, Dai, Rongqing, McClure, Kelly H., Mech, Brian V., Castro, Richard Agustin
• Granted Patent: US 10,137,303 B2
• Time in Patent Office: Days
• US Class Current: 623/25
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37514 Brain implants
• CPC Class Codes: A61N 1/37518 Anchoring of the implants, e.g. fixation
• CPC Class Codes: H01L 2224/05599 Material
• CPC Class Codes: H01L 2224/45144 Gold (Au) as principal constituent
• CPC Class Codes: H01L 2224/48227 connecting the wire to a bond pad of the item
• CPC Class Codes: H01L 2224/48465 the other connecting portion not on the bonding area being a wedge bond, i.e. ball-to-wedge, regular stitch
• CPC Class Codes: H01L 2224/85099 Ambient temperature
• CPC Class Codes: H01L 2224/85399 Material
• CPC Class Codes: H01L 2924/00 Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/00014 the subject-matter covered by the group, the symbol of which is combined with the symbol of this group, being disclosed without further technical details
• CPC Class Codes: H01L 2924/3011 Impedance
• CPC Class Codes: H05K 1/118 specially for flexible printed circuits, e.g. using folded portions
• CPC Class Codes: H05K 1/189 characterised by the use of a flexible or folded printed circuit H05K3/326 takes precedence
• CPC Class Codes: H05K 2201/0154 : Polyimide
• CPC Class Codes: H05K 2201/10098 : Components for radio transmission, e.g. radio frequency identification [RFID] tag, printed or non-printed antennas

Abstract

The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. The output signals provide control for a motor prosthesis and the inputs signals provide sensory feedback for the motor prosthesis. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

Claims

1. An implantable device comprising:

a hermetic package enclosing an electronic circuit suitable to implanted within a head;

a flexible circuit including a plurality of electrodes electrically coupled to the electronic circuit suitable to record neural activity; and

a wireless transceiver electrically coupled to the electronic circuit for sending data derived from the neural activity and receiving sensory data.

2. The implantable device according to claim 1, where the electronic circuit is adapted to record Electrocorticographic Signals.

3. The implantable device according to claim 1, wherein the electronic circuit is adapted to record local field potential signals.

4. The implantable device according to claim 1, wherein the data controls a motor prosthesis.

5. The implantable device according to claim 1, wherein the plurality of electrodes are part of a flexible circuit electrode array bonded to the hermetic package.

6. A flexible circuit electrode array with integrated array cable adapted for neural stimulation comprising:

a polymer base layer forming an array portion and a cable portion, the cable portion adapted to connect to an electronic control unit and the array portion divided into separate fingers;

patterned metal traces deposited on said polymer base layer,

a polymer top layer deposited on said polymer base layer and said polymer top layer defining voids for electrodes;

wherein at least some of the electrodes are in different planes.

7. The flexible circuit electrode array according to claim 6, wherein at least some of the fingers are curved.

8. The flexible circuit electrode array according to claim 6, wherein at least some of the fingers are pointed.

9. The flexible circuit electrode array according to claim 6, wherein the voids include plated electrodes.

10. The flexible circuit electrode array according to claim 9, wherein the plated electrodes have a fractal surface.

11. A neural interface comprising:

a hermetic package enclosing an electronic circuit suitable to implanted within a head;

a wireless transceiver electrically coupled to the electronic circuit for sending data derived from the neural activity and receiving sensory data; and

an electrode array including

a polymer base layer forming an array portion and a cable portion, the cable portion adapted to connect to an electronic control unit and the array portion divided into separate fingers;

patterned metal traces deposited on said polymer base layer,

a polymer top layer deposited on said polymer base layer and said metal traces defining voids for electrodes.

12. The neural interface according to claim 11, wherein said electrode array includes more than 50 electrodes.

13. The neural interface according to claim 11, wherein said electrode array includes more than 75 electrodes.

14. The neural interface according to claim 11, wherein said electrode array includes more than 100 electrodes.

15. The neural interface according to claim 11, wherein said electrode array includes more than 200 electrodes.

16. The neural interface according to claim 11, further comprising a plurality of thin film electrode arrays electrically coupled to the electronics.

17. The neural interface according to claim 11, wherein the hermetic package is suitable to be attached to tissue.

18. The neural interface according to claim 17, wherein the tissue is a dura.

19. The neural interface according to claim 17, wherein the tissue is a cranium.

20. The neural interface according to claim 17, wherein the tissue is a scalp.

21. A flexible circuit electrode array with integrated array cable adapted for neural stimulation comprising:

a polymer base layer forming an array portion and a cable portion, the cable portion adapted to connect to an electronic control unit and the array portion divided into separate fingers;

patterned metal traces deposited on said polymer base layer,

a polymer top layer deposited on said polymer base layer and said polymer top layer defining voids for electrodes;

wherein the fingers define voids suitable to accept an insertion tool.

22. The flexible circuit electrode array according to claim 21, wherein at least some of the fingers are curved.

23. The flexible circuit electrode array according to claim 21, wherein at least some of the fingers are pointed.

24. The flexible circuit electrode array according to claim 21, wherein the voids include plated electrodes.

25. The flexible circuit electrode array according to claim 21, wherein the plated electrodes have a fractal surface.