Antiviral Compounds

• US 20120302556A1
• Filed: 03/29/2012
• Published: 11/29/2012
• Est. Priority Date: 03/29/2011
• Status: Active Grant

• Current Assignee: Prosetta Antiviral Inc.
• Original Assignee: Prosetta Antiviral Inc.
• Inventors: Hurt, Clarence R., Lingappa, Vishwanath, Freeman, Beverly, Atuegbu, Andy, Kitaygorodskyy, Anatoliy
• Granted Patent: US 8,809,317 B2
• Time in Patent Office: Days
• US Class Current: 514/225.8
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: C07D 279/20 with hydrogen atoms directly attached to the ring nitrogen atom

Abstract

Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.

Claims

1. A compound having the structure:

2. A compound of claim 1, wherein R³ is selected from the group consisting of:

alkyloxyalkylamino, di-(alkyloxyalkyl)amino, alkylthioalkylamino, di-(alkylthioalkyl)amino, alkylamino alkylamino, di-(alkylaminoalkyl)amino, aryloxyalkylamino, di-(aryloxyalkyl)amino, arylthioalkylamino, di-(arylthioalkyl)amino, arylaminoalkylamino, di-(arylaminoalkylene)amino, heteroaryloxyalkylamino, di-(heteroaryloxyalkylene)amino, heteroarylthioalkylamino, di-(heteroarylthioalkyl)amino, heteroarylaminoalkylamino, and di-(heteroarylaminoalkyl)amino.

3. A compound of claim 2, wherein at least one of R¹ and R⁸ is selected from the group consisting of:

halo, nitro, cyano, carboxyl, formyl, and optionally substituted alkyl.

4. A compound of claim 3, wherein at least one of R¹ and R⁸ is selected from the group consisting of:

halo, carboxyl, and optionally substituted alkyl.

5. A compound of claim 4, wherein at least one of R¹ and R⁸ is selected from the group consisting of:

halo, carboxyl, and optionally substituted alkyl.

6. A compound of claim 5, wherein at least one of R¹ and R⁸ is halo.

7. A compound of claim 6, wherein least one of R¹ and R⁸ is fluoro.

8. A compound of claim 6, wherein least one of R¹ and R⁸ is chloro.

9. A compound of claim 6, wherein R¹ and R⁸ are both halo.

10. A compound of claim 9, wherein R¹ and R⁸ are both fluoro.

11. A compound of claim 9, wherein R¹ and R⁸ are both chloro.

12. A compound of claim 1, wherein at least one of R¹ and R⁸ is selected from the group consisting of:

halo, carboxyl, and optionally substituted alkyl.

13. A compound of claim 12, wherein at least one of R¹ and R⁸ is selected from the group consisting of:

halo, carboxyl, and optionally substituted alkyl.

14. A compound of claim 13, wherein at least one of R¹ and R⁸ is halo.

17. A compound of claim 14, wherein R¹ and R⁸ are both halo.

18. A compound of claim 17, wherein R¹ and R⁸ are both fluoro.

19. A compound of claim 17, wherein R¹ and R⁸ are both chloro.

20. A method for treating a viral disease in a mammal acted with such disease, comprising administering to such mammal a therapeutically effective amount of the compound of claim 1.

15. A compound of claim 15, wherein at least one of R¹ and R⁸ is fluoro.

16. A compound of claim 15, wherein at least one of R¹ and R⁸ is chloro.