METHOD FOR EVALUATING VASCULAR ENDOTHELIUM FUNCTION AND A SYSTEM THEREFOR
First Claim
1. A method for evaluating vascular endothelium function in a human subject, the method comprising:
- (a) measuring and recording as a function of time the intensity of NADH fluorescence signal emitted from skin tissue cells in a selected location on an upper limb of said subject to obtain a baseline;
(b) blocking blood flow to the upper limb upstream to the selected location, while continuing measuring and recording said intensity as it grows up as a function of time;
(c) releasing the block of blood flow while continuing measuring and recording said intensity as it changes as a function of time until obtaining a stationary state; and
(d) determining parameters indicative of endothelial function from the course of changes of said intensity.
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Accused Products
Abstract
A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal emitted from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.
5 Citations
31 Claims
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1. A method for evaluating vascular endothelium function in a human subject, the method comprising:
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(a) measuring and recording as a function of time the intensity of NADH fluorescence signal emitted from skin tissue cells in a selected location on an upper limb of said subject to obtain a baseline; (b) blocking blood flow to the upper limb upstream to the selected location, while continuing measuring and recording said intensity as it grows up as a function of time; (c) releasing the block of blood flow while continuing measuring and recording said intensity as it changes as a function of time until obtaining a stationary state; and (d) determining parameters indicative of endothelial function from the course of changes of said intensity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for determination of parameters for evaluation of vascular endothelium function in a human subject, the method comprising:
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(a) measuring and recording as a function of time the intensity of NADH fluorescence signal emitted from skin tissue cells in a selected location on an upper limb of said subject to obtain a baseline; (b) blocking blood flow to the upper limb upstream to the selected location, while continuing measuring and recording said intensity as it grows up as a function of time; (c) releasing the block of blood flow while continuing measuring and recording said intensity as it changes as a function of time until obtaining a stationary state; and (d) determining parameters indicative of endothelial function from the course of changes of said intensity. - View Dependent Claims (17, 18, 19, 20, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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16. A system for evaluation of vascular endothelium function in a human subject, said system comprising a means for illumination of a skin tissue of an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time, and a restriction means for blocking and releasing blood flow in the upper limb of said subject.
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21-22. -22. (canceled)
Specification