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RSV IMMUNOGENS, ANTIBODIES AND COMPOSITIONS THEREOF

  • US 20120315270A1
  • Filed: 10/21/2010
  • Published: 12/13/2012
  • Est. Priority Date: 10/21/2009
  • Status: Abandoned Application
First Claim
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1. An RSV immunogen comprising an amino acid sequence of 1LP1_b (SEQ ID NO:

  • 11) having from one to twenty amino acid substitutions, wherein at least one amino acid substitution is selected from the group consisting of;

    (a) substitution of a serine at amino acid position N-25 in SEQ ID NO;

    11;

    (b) substitution of a leucine at amino acid position I-28 in SEQ ID NO;

    11;

    (c) substitution of a serine at amino acid position Q-29 in SEQ ID NO;

    11;

    (d) substitution of an isoleucine at amino acid position L-31 in SEQ ID NO;

    11;

    (e) substitution of an asparagine at amino acid position K-32 in SEQ ID NO;

    11;

    (f) substitution of an aspartic acid at amino acid position K-4 in SEQ ID NO;

    11;

    (g) substitution of a lysine at amino acid position Q-6 in SEQ ID NO;

    11;

    (h) substitution of a lysine at amino acid position Q-7 in SEQ ID NO;

    11;

    (i) substitution of a leucine at amino acid position N-8 in SEQ ID NO;

    11;

    (j) substitution of a serine at amino acid position F-10 in SEQ ID NO;

    11; and

    (k) substitution of an asparagine at amino acid position Y-11 in SEQ ID NO;

    11.

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