METHODS AND APPARATUS FOR ASSESSING ACTIVITY OF AN ORGAN AND USES THEREOF
First Claim
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1. A method for assessing the activity of an organ in a subject with the aid of a digital computer comprising:
- a) accessing by one or more computers a quantitative three-dimensional image of the organ that is represented as voxels, wherein each voxel contains information about the activity of a portion of the organ;
b) calculating by the one or more computers a mean of the activity represented by the voxels, wherein voxels representing values at upper and lower extremes are excluded from calculation of the mean;
c) calculating by the one or more computers a standard deviation of the mean obtained in step b), wherein voxels representing activity above a certain standard deviation of the mean indicate areas of the organ having increased activity and wherein voxels representing activity below a certain standard deviation of the mean indicate areas of the organ having reduced activity; and
d) outputting by the one or more computers to an output device a representation of the organ showing areas of the organ having increased activity and/or reduced activity.
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Abstract
Methods and apparatus are provided for imaging activity of an organ of a subject for diagnosis and prognosis of pathology or injury to the organ, where unaffected portions of the organ are used as a reference for assessing activity of afflicted areas of the organ.
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Citations
26 Claims
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1. A method for assessing the activity of an organ in a subject with the aid of a digital computer comprising:
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a) accessing by one or more computers a quantitative three-dimensional image of the organ that is represented as voxels, wherein each voxel contains information about the activity of a portion of the organ; b) calculating by the one or more computers a mean of the activity represented by the voxels, wherein voxels representing values at upper and lower extremes are excluded from calculation of the mean; c) calculating by the one or more computers a standard deviation of the mean obtained in step b), wherein voxels representing activity above a certain standard deviation of the mean indicate areas of the organ having increased activity and wherein voxels representing activity below a certain standard deviation of the mean indicate areas of the organ having reduced activity; and d) outputting by the one or more computers to an output device a representation of the organ showing areas of the organ having increased activity and/or reduced activity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification