METHODS AND COMPOSITIONS FOR THE TREATMENT OF MIGRAINE HEADACHES
First Claim
1. A method of treating or reducing the likelihood of a migraine, ameliorating the symptoms of a migraine, reducing the frequency or duration of migraines, or treating a condition characterized by increased cardiovascular risk or endothelial dysfunction and musculoskeletal symptoms in a subject in need thereof, said method comprising administering to said subject (i) a statin or an analog thereof and (ii) vitamin D or an analog thereof, wherein said statin or analog thereof and said vitamin D or analog thereof are administered in amounts and for a duration that together are sufficient to treat or reduce the likelihood of a migraine in said subject, to ameliorate the symptoms of a migraine in said subject, to reduce the frequency or duration of migraines in said subject, or to treat said condition.
1 Assignment
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Accused Products
Abstract
The present invention is related to compositions and methods for treating or reducing the likelihood of a migraine, reducing the severity of migraine, reducing the frequency of migraines, reducing the duration of migraine, and ameliorating the symptoms of a migraine. The methods and compositions of the present invention may also be used to treat or prevent condition characterized by increased cardiovascular risk or endothelial dysfunction and musculoskeletal symptoms.
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Citations
40 Claims
- 1. A method of treating or reducing the likelihood of a migraine, ameliorating the symptoms of a migraine, reducing the frequency or duration of migraines, or treating a condition characterized by increased cardiovascular risk or endothelial dysfunction and musculoskeletal symptoms in a subject in need thereof, said method comprising administering to said subject (i) a statin or an analog thereof and (ii) vitamin D or an analog thereof, wherein said statin or analog thereof and said vitamin D or analog thereof are administered in amounts and for a duration that together are sufficient to treat or reduce the likelihood of a migraine in said subject, to ameliorate the symptoms of a migraine in said subject, to reduce the frequency or duration of migraines in said subject, or to treat said condition.
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2-4. -4. (canceled)
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12. (canceled)
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17-18. -18. (canceled)
- 20. A pharmaceutical composition comprising (i) a statin or an analog thereof, (ii) vitamin D or an analog thereof, and (iii) a pharmaceutically acceptable carrier, wherein said statin or analog thereof and said vitamin D or analog thereof are present in an amount that, when administered to a subject, are sufficient to treat or reduce the likelihood of a migraine in said subject, to ameliorate the symptoms of a migraine in said subject, to reduce the frequency or duration of migraines in said subject, or to treat a condition characterized by increased cardiovascular risk or endothelial dysfunction and musculoskeletal symptoms in said subject.
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21-23. -23. (canceled)
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27-29. -29. (canceled)
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36. (canceled)
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40-41. -41. (canceled)
Specification