Embolic Implant and Method of Use

• US 20120330348A1
• Filed: 05/30/2012
• Published: 12/27/2012
• Est. Priority Date: 06/03/2011
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Reverse Medical Corporation (Medtronic Plc)
• Inventors: Strauss, Brian Michael, Valko, Jeffrey J., Lenker, Jay A., Pecor, Robert A., Barker, Peter, Castaneda, Maricruz
• Granted Patent: US 8,641,777 B2
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12154 having stretch limiting means
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00539 hydraulically
• CPC Class Codes: A61B 2017/00544 pneumatically
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/12068 detachable by heat
• CPC Class Codes: A61B 2017/12077 Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory
• CPC Class Codes: A61B 2017/12081 detachable by inflation
• CPC Class Codes: A61B 2017/12086 magnetically detachable
• CPC Class Codes: A61B 2017/12095 Threaded connection
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/823 : Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2220/0058 : soldered or brazed or welded
• CPC Class Codes: A61F 2230/0071 : spherical
• CPC Class Codes: A61F 2230/0076 : ellipsoidal or ovoid
• CPC Class Codes: A61L 2400/04 : Materials for stopping bleeding
• CPC Class Codes: A61L 2400/14 : Adhesives for ostomy devices
• CPC Class Codes: A61L 2400/16 : Materials with shape-memory or superelastic properties
• CPC Class Codes: A61L 2420/04 : Coatings containing a composite material such as inorganic/organic, i.e. material comprising different phases
• CPC Class Codes: A61L 2430/36 : for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61L 31/022 : Metals or alloys
• CPC Class Codes: A61L 31/10 : Macromolecular materials
• CPC Class Codes: A61L 31/146 : Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 27/18 : Homopolymers or copolymers or tetrafluoroethene

Abstract

A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Claims

1. An embolic implant for parent artery occlusion, said embolic implant characterized by a proximal end and a distal end, said embolic implant comprising:

a wire frame structure characterized by a proximal end and a distal end, said wire-frame structure comprising;

a pair of opposing zigzag segments including a plurality of V-shaped elements joined at the open end of the V-shaped segments via short longitudinally aligned struts to form a central portion of the wire-frame structure, said short struts being longitudinally displaced from each other, said V-shaped elements defining vertices pointing away from the center of the wire frame structure;

a plurality of serpentine longitudinally oriented struts extending from the proximally pointing vertices of the V-shaped elements, said serpentine longitudinally oriented struts being joined together near the radial center of the wire-frame structure at the proximal end of the embolic implant;

wherein the wireframe structure is formed of a self-expanding material; and

an electrolytic detachment joint fixed to the proximal end of the embolic implant; and

a blood impermeable membrane disposed over the proximal end of the embolic implant, said blood impermeable membrane extending over at least one of the zigzag segments.

2. The embolic implant of claim 1 wherein the wire-frame structure further comprises:

a second plurality of serpentine longitudinally oriented struts extending from the distally pointing vertices of the V-shaped elements, said serpentine longitudinally oriented struts being joined together near the radial center of the wire-frame structure at the proximal end of the embolic implant.

3. The embolic implant of claim 1 wherein the wire-frame structure further comprises a pseudoelastic metal alloy.

4. The embolic implant of claim 1 wherein the membrane comprises ePTFE impregnated with an adhesive, said membrane being glued to the wire-frame structure.

5. The embolic implant of claim 1 wherein the membrane comprises two layers of ePTFE impregnated with an adhesive, said membrane being glued to the wire-frame structure.

6. The embolic implant of claim 1 wherein the wire frame structure has a fully expanded configuration with a diameter of about 5 mm, and a second fully compacted configuration with a diameter of less than about 1 mm.

14. A method of treating a defect in the cerebral blood vessel of a patient, said method comprising:

providing a first and second embolic implants according to claim 1;

implanting the first embolic implant in the cerebral blood vessel at a location distal to the defect, between the defect and a source of redundant blood flow;

implanting the second embolic implant in the cerebral blood vessel at a location proximal to the defect.

7. A system for parent artery occlusion, said system comprising:

an said embolic implant characterized by a proximal end and a distal end, said embolic implant comprising;

a wire frame structure characterized by a proximal end and a distal end, said wire-frame structure comprising;

a pair of opposing zigzag segments including a plurality of V-shaped elements joined at the open end of the V-shaped segments via short longitudinally aligned struts to form a central portion of the wire-frame structure, said short struts being longitudinally displaced from each other, said V-shaped elements defining vertices pointing away from the center of the wire frame structure;

a plurality of serpentine longitudinally oriented struts extending from the proximally pointing vertices of the V-shaped elements, said serpentine longitudinally oriented struts being joined together near the radial center of the wire-frame structure at the proximal end of the embolic implant;

wherein the wireframe structure is formed of a self-expanding material; and

an electrolytic detachment joint fixed to the proximal end of the embolic implant; and

a blood impermeable membrane disposed over the proximal end of the embolic implant, said blood impermeable membrane extending over at least one of the zigzag segments;

a delivery catheter adapted for navigation through the patient'"'"'s vasculature to the parent artery, said delivery catheter also adapted to house the embolic implant within the distal tip of the delivery catheter;

a deliver rod slidably disposed within the delivery catheter, said delivery rod having a distal end fixed to the embolic implant via the electrolytic detachment joint;

a conductor for supplying power to the electrolytic detachment joint from a power supply.

8. The system of claim 7 wherein the wire-frame structure further comprises:

a second plurality of serpentine longitudinally oriented struts extending from the distally pointing vertices of the V-shaped elements, said serpentine longitudinally oriented struts being joined together near the radial center of the wire-frame structure at the proximal end of the embolic implant.

9. The system of claim 7 wherein the wire-frame structure further comprises a pseudoelastic metal alloy.

10. The system of claim 7 wherein the membrane comprises ePTFE impregnated with an adhesive, said membrane being glued to the wire-frame structure.

11. The system of claim 7 wherein the membrane comprises two layers of ePTFE impregnated with an adhesive, said membrane being glued to the wire-frame structure.

12. The system of claim 7 wherein the wire frame structure has a fully expanded configuration with a diameter of about 5 mm, and a second fully compacted configuration with a diameter of less than about 1 mm.

13. The system of claim 7 wherein the wire frame structure has a fully expanded configuration with a diameter of about 5 mm, and a second fully compacted configuration with a diameter of less than about 0.6 mm.