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SYSTEMS AND METHODS FOR HYBRID ASSEMBLY OF NUCLEIC ACID SEQUENCES

  • US 20120330559A1
  • Filed: 06/20/2012
  • Published: 12/27/2012
  • Est. Priority Date: 06/21/2011
  • Status: Abandoned Application
First Claim
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1. A computer implemented method for assembling a nucleic acid sequence, comprising:

  • receiving, into a memory, a plurality of single fragment sequence reads and a plurality of paired fragment sequence reads, each paired fragment sequence read comprising at least two sequence reads separated by an insert;

    assembling the single fragment sequence reads into a plurality of contigs;

    mapping the paired fragment sequence reads to the contigs;

    identifying a gap region comprising a portion of the partially assembled nucleic acid sequence for which the single fragment sequence reads do not map, andutilizing hanging pairwise sequence reads of the mapped paired fragment sequence reads to fill in the gap region using a processor.

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