Synthetic Antibacterial Clay Compositions and Method of Using Same

• US 20130004544A1
• Filed: 06/01/2010
• Published: 01/03/2013
• Est. Priority Date: 06/02/2009
• Status: Abandoned Application

• Current Assignee: Arizona Board of Regents (University of Arizona)
• Original Assignee: Arizona Board of Regents (University of Arizona)
• Inventors: Eberl, Dennis D., Blum, Alex E., Metge, David W., Williams, Lynda, Harvey, Ronald W.
• Application Number:
  US13/515,309
• Publication Number:
  US 20130004544A1
• Time in Patent Office: Days
• US Class Current: 424/400
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

The present invention is directed to synthetic bactericidal compositions having clay like properties and a method of using these compositions to topically treat bactenally-caused skin infections and skin diseases. The compositions within the scope of the invention compnse a bactericidal effective amount of a reducing agent, such as pyπte, marcasite, pyrrhotite, FeS2, FeS, FeS04—or other reducing agents having like properties, and a natural clay or clay mineral and/or synthetic clay or clay mineral, or other suitable matenals having clay-like properties. The synthetic bactericidal compositions are synthesized by adding the reducing agent to the clay or clay mineral. It is the presence of the reducing agent in said compositions that renders them bacteπcidal. The clays serve as a vehicle within which the reducing agent is dispersed, as a diluent to the reducing agent, and also as an adsorbent and low permeability banner in use of the composition

Claims

1. (canceled)

4. The composition of claim 1, wherein said fine particulate reducing agent is present in said composition in an amount ranging from approximately 0.5% wt. to 10% wt. of said composition.

2. A synthetic bactericidal composition, comprising

a bactericidal effective amount of a particulate reducing agent selected from the group consisting of pyrite, marcasite, pyrrhotite, FeS₂, FeS, FeSO₄, and a combination thereof, and

a clay or clay mineral comprising a smectite clay, an illite clay, a rectorite clay, or a combination thereof.

5. The composition of claim 2, wherein the particle size of said reducing agent is less than 1 micron.

8. The composition of claim 2, wherein said reducing agent is pyrite, and wherein said day is a smectite day.

9. The composition of claim 8, wherein said composition comprises 0.5% wt. to 10% wt. fine particulate pyrite;

and wherein the particle size of said pyrite is less than one micron.

10. The composition of claim 8, wherein said composition comprises approximately 10% wt. pyrite and a Ca-saturated smectite clay.

19. A method of treating a bacterial skin infection, comprising topically applying to the site of said bacterial skin infection a composition as set forth in claim 2.

20. A method of treating a bacterial skin infection, comprising:

adding to a composition as set forth in claim 2 a suitable aqueous liquid in an amount so as to create a paste; and

topically applying said hydrated composition to the site of said bacterial skin infection.

21. The method of claim 20, wherein said suitable aqueous liquid is water.

22. The method of claim 20, wherein said bacterial skin infection is caused by one or more bacteria selected from the group consisting of Mycobacterium ulcerans, E. coli, ESBL E. coli, Pseudomonas aeruginosa, Salmonella typhimurium, Staphylococcus epidermidis, S. aureus, MRSA, M. smegmatis, Streptococcus sp. and M. marinum.

3. (canceled)

6-7. -7. (canceled)

11-18. -18. (canceled)

23. A method of making a synthetic bactericidal composition comprising:

adding a bactericidal effective amount of a reducing agent in fine particulate form to a non-bactericidal clay or non-bactericidal day mineral, wherein said reducing agent is pyrite, marcasite, pyrrhotite, FeS₂, FeSO₄ FeS; and

rendering said composition bactericidal.

25. The method of claim 23, wherein said fine particulate reducing agent is added to said clay or day mineral so as to be present in said bactericidal composition in an amount ranging from 0.5% wt. to 10% wt.

26. The method of claim 23, wherein said non-bactericidal day or said non-bactericidal day mineral are synthetic.

27. The method of claim 23, wherein said non-bactericidal day is a smectite day, an illite clay;

or a rectorite clay.

24. (canceled)

28-33. -33. (canceled)

34. A method of determining whether a day has bactericidal properties, wherein said method comprises chemically and/or mineralogically analyzing said clay to determine the presence of a reducing agent comprising pyrite or marcasite therein or measuring the oxidation-reduction potential of a slurry containing said day.

35-36. -36. (canceled)

37. A synthetic antibacterial day or day mineral, wherein said antibacterial clay or day mineral is produced by:

synthesizing a clay or day mineral or by treating or altering the chemistry of a natural clay or day mineral to yield a synthetic antibacterial day or day mineral containing within its crystal structure or within its exchange positions an antibacterial effective amount of a reducing agent;

wherein said reducing agent ferrous iron and renders said clay or day mineral antibacterial.

38-43. -43. (canceled)