Polymer Nanofilm Coatings

• US 20130004560A1
• Filed: 09/11/2012
• Published: 01/03/2013
• Est. Priority Date: 06/08/2007
• Status: Abandoned Application

• Current Assignee: Northwestern University, Regents of the University of California (University of California)
• Original Assignee: Northwestern University, Regents of the University of California (University of California)
• Inventors: Chen, Mark, Pierstorff, Erik, Huang, Houjin, Chow, Edward K., Cheng, Genhong, Ho, Dean
• Application Number:
  US13/609,588
• Publication Number:
  US 20130004560A1
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/24355 Continuous and nonuniform or irregular surface on layer or component [e.g., roofing, etc.]
• CPC Class Codes: Y10T 428/24975 No layer or component greater than 5 mils thick

Abstract

Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.

Claims

1. A membrane comprising:

a) a first layer comprising parylene, and

b) a second layer comprising a copolymer selected from the group consisting of polyethylene oxidepolymethylmethacrylate, polymethyloxazoline-polydimethylsiloxiane-polymthoxazoline, and a mixture thereof,

wherein the membrane has a thickness between 0.1 nm and 20 nm.

2. The membrane of claim 1, wherein said membrane comprises a third layer, wherein the third layer comprises parylene.

3. The membrane of claim 2, wherein said second layer is between the first and second layers.

4. The membrane of claim 1, further comprising at least one therapeutic agent.

5. The membrane of claim 4, wherein the at least one therapeutic agent is within the second layer.

6. The membrane of claim 1, wherein the first layer comprises nonoporous parylene.

7. The membrane of claim 2, wherein the third layer comprises rough parylene C.

8. The membrane of claim 1, wherein the copolymer comprises a single layer having a thickness from about 1 nm to about 10 nm.