METHODS AND SEQUENCES TO SUPPRESS PRIMATE HUNTINGTON GENE EXPRESSION
First Claim
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1. An isolated nucleic acid duplex comprising a first strand of nucleic acid and a second strand of nucleic acid, wherein the first strand comprises at least 19 contiguous nucleotides encoded by one of SEQ ID NOs:
- 8, 6, 2, 3, or 5, and the second strand is complementary to at least 15 contiguous nucleotides within a respective SEQ ID NO;
8, 6, 2, 3, or 5 of the first strand.
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Abstract
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatto and Homo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease.
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Citations
22 Claims
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1. An isolated nucleic acid duplex comprising a first strand of nucleic acid and a second strand of nucleic acid, wherein the first strand comprises at least 19 contiguous nucleotides encoded by one of SEQ ID NOs:
- 8, 6, 2, 3, or 5, and the second strand is complementary to at least 15 contiguous nucleotides within a respective SEQ ID NO;
8, 6, 2, 3, or 5 of the first strand. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 21, 22)
- 8, 6, 2, 3, or 5, and the second strand is complementary to at least 15 contiguous nucleotides within a respective SEQ ID NO;
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12. An isolated nucleic acid duplex comprising a first strand of nucleic acid and a second strand of nucleic acid, wherein the first strand comprises at least 19 contiguous nucleotides encoded by one of SEQ ID NOs:
- 8, 6, 3, or 5, and the second strand is complementary to at least 15 contiguous nucleotides within a respective SEQ ID NO;
8, 6, 3, or 5 of the first strand, wherein the nucleic acid duplex is between 19 and 30 base pairs in length. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
- 8, 6, 3, or 5, and the second strand is complementary to at least 15 contiguous nucleotides within a respective SEQ ID NO;
Specification