Methods and Systems for Measurement of Tear Glucose Levels
First Claim
1. A sensor for determining glucose concentration in a tear fluid sample, comprising:
- a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample; and
a reference electrode disposed adjacent the working electrode;
wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.
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Abstract
A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.
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Citations
30 Claims
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1. A sensor for determining glucose concentration in a tear fluid sample, comprising:
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a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample; and a reference electrode disposed adjacent the working electrode; wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for determining glucose concentration in a tear fluid sample, comprising:
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a vessel for receiving the tear fluid sample, the vessel including an immobilized glucose oxidase enzyme portion on an inner wall thereof for reacting with glucose in the tear fluid sample; and a sensor comprising a working electrode including a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample, and a reference electrode disposed adjacent the working electrode; wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method for determining glucose concentration in a tear fluid sample, comprising:
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providing a sensor system including a vessel for receiving a tear fluid sample, a working electrode including a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample, a reference electrode disposed adjacent the working electrode, and an immobilized glucose oxidase enzyme portion disposed on one of the working electrode and the vessel, the enzyme portion for reacting with glucose in the tear fluid sample; and electrochemically reacting the enzyme portion with glucose in the tear fluid sample to generate a current related to the glucose concentration in the tear fluid sample. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
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Specification