IMMEDIATE/DELAYED DRUG DELIVERY
2 Assignments
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Accused Products
Abstract
In one aspect, the present invention is concerned with a treatment where it is desired that an active agent is designed to be released immediately following administration and again at a time point some time after administration of the active agent. The present invention is particularly suited to administering an agent which may be released before sleep and whilst a subject is sleeping. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for an immediate, followed by a delayed release of drug.
55 Citations
36 Claims
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1-16. -16. (canceled)
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17. A press-coated tablet formulation for an immediate, followed by a delayed release of an active agent, the tablet comprising
(a) a core comprising an active agent together with an excipient(s); - and
(b) a delayed release layer surrounding the core and comprising a wax and LH-32 in a ratio of 40;
60 to 60;
40 w/w;
wherein the delayed release layer substantially delays release of the active agent within the core for between 3-8 hours after administration of the tablet by a subject and thereafter a pulsed release of the active agent from the core occurs, such that at least 70% of the active agent in the core is released within 5-45 mins; and(c) a top-coating layer comprising a portion of an active agent together with one or more excipients wherein a substantially immediate pulsed release of the active agent occurs following administration to the subject of the tablet. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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- 27. A press-coated tablet comprising a NSAID agent for alleviating pain and/or inflammation, wherein the tablet is intended to be administered immediately prior to a subject going to sleep and wherein a portion of the NSAID is initially to be released immediately following administration and a further portion is released following a period of delay after administration.
- 29. A method of alleviating pain and/or inflammation such as associated with arthritis, the method comprising administering a press-coated tablet comprising an NSAID(s), to a subject, immediately before the subject intends sleeping, wherein the formulation releases an NSAID immediately following administration and further releases an NSAID following a period of delay after administration of the tablet.
Specification