COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS
First Claim
Patent Images
1. A composition formulated for oral consumption, comprising:
- (a) leucine and/or one or more metabolites thereof; and
(b) a sirtuin pathway activator;
wherein the composition is synergistically effective in increasing sirtuin pathway output by at least about 1 fold as compared to that of component (a) or (b) when being used alone, wherein the increased sirtuin-pathway output is evidenced by an increase in a physiological effect selected from the group consisting of fatty acid oxidation, mitochondrial biogenesis, glucose uptake, palmitate uptake, oxygen consumption, weight loss, visceral adipose tissue loss, insulin sensitivity, an inflammation marker level, vasodilatation, and body temperature, when (i) media from myotubes or adipocytes treated with the composition is administered to the other of the myotubes or adipocytes, (ii) the composition is administered to myotubes or adipocytes, or (iii) the composition is administered to a subject.
2 Assignments
0 Petitions
Accused Products
Abstract
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
41 Citations
30 Claims
-
1. A composition formulated for oral consumption, comprising:
-
(a) leucine and/or one or more metabolites thereof; and (b) a sirtuin pathway activator; wherein the composition is synergistically effective in increasing sirtuin pathway output by at least about 1 fold as compared to that of component (a) or (b) when being used alone, wherein the increased sirtuin-pathway output is evidenced by an increase in a physiological effect selected from the group consisting of fatty acid oxidation, mitochondrial biogenesis, glucose uptake, palmitate uptake, oxygen consumption, weight loss, visceral adipose tissue loss, insulin sensitivity, an inflammation marker level, vasodilatation, and body temperature, when (i) media from myotubes or adipocytes treated with the composition is administered to the other of the myotubes or adipocytes, (ii) the composition is administered to myotubes or adipocytes, or (iii) the composition is administered to a subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 29)
-
-
21. A composition comprising:
-
(a) leucine and/or one or more metabolites thereof; and (b) a sub-therapeutic amount of an anti-diabetic agent selected from the group consisting of biguanide and thiazolidinedione; wherein the combination when administered to a subject synergistically increases insulin sensitivity in said subject as compared to administering to a subject component (a) or component (b) alone. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 30)
-
Specification