Systems and Methods for Inter-Population Neurobehavioral Status Assessment Using Profiles Adjustable to Testing Conditions

• US 20130018592A1
• Filed: 07/16/2012
• Published: 01/17/2013
• Est. Priority Date: 07/15/2011
• Status: Abandoned Application

• Current Assignee: Pulsar Informatics, Inc.
• Original Assignee: Pulsar Informatics, Inc.
• Inventors: Mollicone, Daniel Joseph, Mott, Christopher Grey, Wan, Kevin Gar
• Application Number:
  US13/550,522
• Publication Number:
  US 20130018592A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Systems and methods for inter-population assessment of neurobehavioral status employ neurobehavioral profiles to accommodate differing external conditions. Population profiles and external condition data are provided to a neurobehavioral performance model to determine neurobehavioral status under external conditions. Alternatively, neurobehavioral performance values may be retrieved from the profile when such values are stored in conjunction with external condition data. Comparisons of the resulting neurobehavioral status(es) are then determined, and may comprise without limitation one or more of: performance deltas, statistical parameter differences, rankings, above/below performance threshold determinations, pass/fail indicators, and countermeasure recommendations. Populations may comprise pluralities, individuals and empty (“null”) sets. Comparisons may also pertain to one or more relevant times of interest and one or more sets of testing conditions. Fields of application include (without limitation) operational and military fatigue management, medical diagnosis and treatment, fatigue countermeasure training and individualization, sleep research, academic and scientific research, and/or the like.

Claims

1. A method employing neurobehavioral profiles with a computer for determining a comparison of the neurobehavioral status of a first population relative to the neurobehavioral status of a second population, the method comprising:

receiving, at a computer, a first neurobehavioral profile for a first population, the first neurobehavioral profile indicating a neurobehavioral status of the first population corresponding to a set of testing conditions;

receiving, at the computer, a second neurobehavioral profile for a second population, the second neurobehavioral profile indicating a neurobehavioral status of the second population corresponding to a set of testing conditions;

receiving, at the computer, a first set of testing-condition data, the first set of testing-condition data being indicative of a first set of testing conditions;

determining, with the computer, a neurobehavioral status for the first population associated with the first set of testing conditions, wherein the neurobehavioral status for the first population associated with the first set of testing conditions is based at least in part on the received first neurobehavioral profile and the received first set of testing-condition data;

determining, with the computer, a neurobehavioral status for the second population associated with the first set of testing conditions, wherein the neurobehavioral status for the second population associated with the first set of testing conditions is based at least in part on the received second neurobehavioral profile and the received first set of testing-condition data; and

determining, with the computer, a comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status of the second population associated with the first set of testing conditions.

2. A method according to claim 1 wherein the received first neurobehavioral profile comprises at least in part one or more neurobehavioral trait values.

3. A method according to claim 2 wherein determining the neurobehavioral status for the first population associated with the first set of testing conditions comprises applying a neurobehavioral performance model to the first neurobehavioral profile and the first set of testing-condition data.

4. A method according to claim 1 wherein the received first neurobehavioral profile comprises at least in part one or more neurobehavioral performance values each associated with one or more testing conditions.

5. A method according to claim 4 wherein determining the neurobehavioral status for the first population associated with the first set of testing conditions comprises identifying neurobehavioral performance values with associated testing conditions that match the testing conditions indicated by the received first set of testing-condition data.

6. A method according to claim 1:

wherein the received second neurobehavioral profile comprises at least in part one or more neurobehavioral trait values, and

wherein determining the neurobehavioral status for the first population associated with the first set of testing conditions comprises applying a neurobehavioral performance model to the first neurobehavioral profile and the first set of testing-condition data.

7. A method according to claim 1:

wherein the received second neurobehavioral profile comprises at least in part one or more neurobehavioral performance values each associated with one or more testing conditions; and

wherein determining the neurobehavioral status for the second population associated with the first set of testing conditions comprises selecting neurobehavioral performance values with associated testing conditions that match the testing conditions indicated by the received first set of testing-condition data.

8. A method according to claim 1 wherein the first set of testing-condition data corresponds to a first time of interest, and further comprises:

receiving, at the computer, a second set of testing-condition data, the second set of testing-condition data being indicative of a second set of testing conditions corresponding to a second time of interest;

determining, with the computer, a neurobehavioral status for the first population associated with the second set of testing conditions, wherein the neurobehavioral status for the first population associated with the second set of testing conditions is based at least in part on the received first neurobehavioral profile and the received second set of testing-condition data;

determining, with the computer, a neurobehavioral status for the second population associated with the second set of testing conditions, wherein the neurobehavioral status for the second population associated with the second set of testing conditions is based at least in part on the received second neurobehavioral profile and the received second set of testing-condition data; and

determining, with the computer, one or more of;

a comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status of the first population associated with the second set of testing conditions,

a comparison of the determined neurobehavioral status of the first population associated with the second set of testing conditions relative to the determined neurobehavioral status of second the population associated with the second set of testing conditions, and

a comparison of the determined neurobehavioral status of the second population associated with the first set of testing conditions relative to the determined neurobehavioral status of the second population associated with the second set of testing conditions.

9. A method according to claim 1 wherein the first population comprises an individual.

10. A method according to claim 1 wherein the second population comprises an individual.

11. A method according to claim 1 either wherein the first population is a subset of the second population or wherein the second population is a subset of the first population.

12. A method according to claim 11 either wherein the first population comprises a plurality of individuals and the second population comprises an individual selected from the first population or wherein the second population comprises a plurality of individuals and the first population comprises an individual selected from the second population.

14. A method according to claim 1 wherein the first population and the second population are the same population.

15. A method according to claim 1 wherein the determined comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status of the second population associated with the first set of testing conditions comprises one or more of:

a difference in one or more statistical measures of the determined neurobehavioral status of the first population associated with the first set of testing conditions and the determined neurobehavioral status of the second population associated with the first set of testing conditions, and

a ratio of the number of individuals of the first population with a neurobehavioral status above or below a threshold to the number of individuals of the second population with a neurobehavioral status above or below the threshold.

16. A method according to claim 9 wherein the determined comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status of the second population associated with the first set of testing conditions comprises one or more of:

a percentile raking of the individual with respect to the second population,

a numerical ranking of the individual with respect to the second population,

a percentage of the second population with neurobehavioral response above or below the neurobehavioral status of the individual, and

the number of members of the second population with neurobehavioral status above or below the neurobehavioral response of the individual.

17. A method according to claim 10 wherein the determined comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status to the second population associated with the first set of testing conditions comprises one or more of:

a percentage of the first population with a neurobehavioral status above or below the neurobehavioral status of the individual,

a number of individuals within the first population with a neurobehavioral status above or below the neurobehavioral status of the individual, and

a ratio of the number of individuals within the first population with a neurobehavioral status above the neurobehavioral status of the individual to the number of individuals within the first population with a neurobehavioral status below the neurobehavioral status of the individual.

18. A method according to claim 6 wherein the first population and the second population comprise the same individual, and wherein one or more of:

the determined comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status of the first population associated with the second set of testing conditions, and

the determined comparison of the determined neurobehavioral status of the second population associated with the first set of testing conditions relative to the determined neurobehavioral status of the second population associated with the second set of testing conditions;

comprises one or more of;

a difference in neurobehavioral status of the individual under the first and the second sets of testing conditions,

a percentage change in neurobehavioral status of the individual under the first and the second sets of testing conditions, and

a recommended countermeasure to improve neurobehavioral performance to a particular threshold under either the first or the second sets of testing conditions.

19. A method according to claim 1 wherein the first population comprises a first individual, wherein the second population comprises a second individual, and wherein the determined comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status to the second population associated with the first set of testing conditions comprises one or more of:

a difference in determined neurobehavioral status of one or more of the first and second individual under one or more of the first and second set of testing conditions,

a percentage change in determined neurobehavioral status of one or more of the first and second individual under one or more of the first and second set of testing conditions, and

a recommended countermeasure for one or more of the first and second individuals to improve neurobehavioral performance to a particular threshold.

20. A method according to claim 8 wherein the first set of testing conditions and the second set of testing conditions are the same set of testing conditions.

21. A method according to claim 8 wherein the first time of interest and the second time of interest are the same or a comparable time of interest.

22. A method according to claim 1 wherein one or more of the first neurobehavioral profile and the second neurobehavioral profile comprise one or more pairs of statistical parameters corresponding to the distribution of first and second sets of neurobehavioral traits across the first and second populations, respectively.

23. A method according to claim 1 wherein one or more of the first neurobehavioral profile and the second neurobehavioral profiles comprises one or more normal distributions of a neurobehavioral trait across the first and second populations, respectively.

24. A method according to claim 22 wherein the one or more pairs of statistical parameters comprises one or more of:

a mean and a variance; and

a median and a standard deviation.

25. A method according to claim 1 wherein at least one of the first population and the second population comprises at least one of a workforce, a military unit, a plurality of individuals with shared demographics, a plurality of individuals with one or more shared medical conditions, an experimental group in research, and a control group in research.

26. A method according to claim 1 wherein the first set of testing conditions comprise one or more of:

sleep and work history, external factors, dosing or application of neurobehavioral countermeasures, and presence of neurobehavioral stressors.

27. A method according to claim 26 wherein the sleep and work history data comprises one or more of:

actigraphy, a sleep schedule, one or more sleep onset times, one or more sleep interval durations, a duration of total time in bed over an extended period, a work schedule, one or more work shift identifiers, one or more work start times, one or more work interval durations, and a duration of total work time over an extended interval.

28. A method according to claim 26 wherein the external factors comprise one or more of:

weather data, environmental data, and noise or sound data.

29. A method according to claim 26 wherein the dosing or application of neurobehavioral countermeasures comprises one or more of:

a schedule of stimulant ingestion, a sleep schedule, a schedule of physical activity, and an exercise schedule.

30. A method according to claim 26 wherein the existence of neurobehavioral stressors comprises the existence of one or more of:

prolonged wakefulness, circadian misalignment, extended time on duty, and night work.

31. A method according to claim 26 wherein the first set of testing-condition data corresponds to a first time of interest, and the first time of interest comprises a time related to when one or more members of the first population:

report for work, report for military duty, undergo medical examination, undergo medical treatment, drive a vehicle, operate machinery, undergo physical activity, undergo athletic competition, enroll in the military from civilian life, resume civilian life after military duty, and engage in a task with an identifiable neurobehavioral or fatigue risk.

32. A method according to claim 1 wherein the first set of testing-condition data corresponds to a the first time of interest, the first time of interest comprising one or more of a time interval, a plurality of time intervals, an exact time, and a plurality of exact times.

33. A method according to claim 8 wherein the second time of interest represented by the received first set of testing-condition data comprises a time related to when one or more members of the first population:

report for work, report for military duty, undergo medical examination, undergo medical treatment, drive a vehicle, operate machinery, undergo physical activity, undergo athletic competition, enroll in the military from civilian life, resume civilian life after military duty, and engage in a task with an identifiable neurobehavioral or fatigue risk.

34. A method according to claim 1 wherein one or more of the determined neurobehavioral status for the first population associated with the first set of testing conditions and the determined neurobehavioral status for the second population associated with the first set of testing conditions comprise neurobehavioral performance assessment metrics for one or more of:

the psychomotor vigilance test, the motor praxis test, the visual object learning test, the fractal-2-back test, the conditional exclusion task, the matrix reasoning task, the line orientation test, the emotion recognition test, the balloon analog risk task, the digit symbol substitution test, the forward digit span, the reverse digit span, the serial addition and subtraction task, the go/no-go task, the word-pair memory task, the word recall test, the motor skill learning task, the threat detect test, the descending subtraction task, the PANAS-X questionnaire, the pre-sleep/post-sleep questionnaires for astronauts, the Beck depression inventory, the conflict questionnaire, the Karolinska drowsiness scales, the visual analog scales, the Karolinska sleepiness scales, the POMS/POMS-SF questionnaires, and the Stroop test.

35. A method according to claim 1 wherein one or more of the determined neurobehavioral status for the first population associated with the first set of testing conditions and the determined neurobehavioral status for the second population associated with the first set of testing conditions comprise neurobehavioral performance assessment metrics for one or more of:

a workplace-specific task, a standardized line-of-work task, a special tasks, and performance as measured by an embedded performance monitoring system.

36. A method according to claim 2 wherein the biomathematical model comprises the two-process model of fatigue prediction.

37. A method according to claim 36 wherein the one or more neurobehavioral traits values comprising the first neurobehavioral profile comprise values for one or more of:

φ

, γ

, τ

, a₁, ρ

_w, ρ

_s, κ

, and ε

.

38. A method according to claim 2 wherein the biomathematical model comprises one or more of:

the three-process model of alertness, the two-process model revisited, the process-U model, the modified two-process model, the QinetiQ approach, the circadian alertness simulator, the new model class, nonparametric approaches, and neural networks.

39. A method according to claim 2 wherein the one or more of neurobehavioral trait values comprise values for one or more of:

daily sleep need,

whether the testing subject is relatively more alert late at night or relatively more alert in the early morning,

medical disorder severity,

sleep inertia severity,

drug sensitivity,

response bias,

the degree of performance deficits associated with occurrence of or varying degrees of night work,

the degree of performance deficits associated with occurrence of or varying degrees of extended wakefulness,

the degree of performance deficits associated with occurrence of or varying degrees of chronic sleep restriction,

the degree of performance deficits associated with occurrence of or varying degrees of shift work,

the degree of performance deficits associated with occurrence of or varying degrees of extended time on task,

the degree of performance deficits associated with occurrence of or varying degrees of jet lag,

the degree of performance deficits associated with occurrence of or varying degrees of shifts in sleep schedule,

the degree of performance deficits associated with occurrence of or varying degrees of sleep disruption,

the degree of performance deficits associated with occurrence of or varying degrees of medical disorders,

the degree of performance deficits associated with occurrence of or varying degrees of sleep disorders,

the degree of performance deficits associated with occurrence of or varying degrees of medical treatments,

rate of change of the testing subject'"'"'s performance during extended wakefulness,

rate of change of the testing subject'"'"'s performance across multiple days of restricted sleep,

recovery rate of performance for the testing subject during sleep,

extent that time of day influences the performance level of the testing subject, and

an aptitude of the testing subject for a specific performance task.

13. A method according to claim 13 wherein the first population and the second population comprise the same individual.

40. A computer program product embodied in a non-transitory medium and comprising computer-readable instructions that, when executed by a suitable computer, cause the computer to perform a method for determining a comparison of the neurobehavioral status of a first population relative to the neurobehavioral status of a second population, the method comprising:

receiving, at a computer, a first neurobehavioral profile for a first population, the first neurobehavioral profile indicating a neurobehavioral status of the first population corresponding to a set of testing conditions;

receiving, at the computer, a second neurobehavioral profile for a second population, the second neurobehavioral profile of indicating a neurobehavioral status of the second population corresponding to a set of testing conditions;

receiving, at the computer, a first set of testing-condition data, the first set of testing-condition data being indicative of a first set of testing conditions;

determining, with the computer, a neurobehavioral status for the first population associated with the first set of testing conditions, wherein the neurobehavioral status for the first population associated with the first set of testing conditions is based at least in part on the received first neurobehavioral profile and the received first set of testing-condition data;

determining, with the computer, a neurobehavioral status for the second population associated with the first set of testing conditions, wherein the neurobehavioral status for the second population associated with the first set of testing conditions is based at least in part on the received second neurobehavioral profile and the received first set of testing-condition data; and

determining, with the computer, a comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status of the second population associated with the first set of testing conditions.

41. A system for determining a comparison of the neurobehavioral status of a first population relative to the neurobehavioral status of a second population, the system comprising:

a data storage unit, the data storage unit containing a database of neurobehavioral profiles and a database of testing-condition data,

a processor capable of receiving neurobehavioral profiles and testing-condition data from the data storage unit,

wherein determining a comparison of the neurobehavioral status of a first population relative to the neurobehavioral status of a second population comprises;

receiving, at a computer, a first neurobehavioral profile for a first population, the first neurobehavioral profile indicating a neurobehavioral status of the first population corresponding to a set of testing conditions;

receiving, at the computer, a second neurobehavioral profile for a second population, the second neurobehavioral profile of indicating a neurobehavioral status of the second population corresponding to a set of testing conditions;

receiving, at the computer, a first set of testing-condition data, the first set of testing-condition data being indicative of a first set of testing conditions;

determining, with the computer, a neurobehavioral status for the first population associated with the first set of testing conditions, wherein the neurobehavioral status for the first population associated with the first set of testing conditions is based at least in part on the received first neurobehavioral profile and the received first set of testing-condition data;

determining, with the computer, a neurobehavioral status for the second population associated with the first set of testing conditions, wherein the neurobehavioral status for the second population associated with the first set of testing conditions is based at least in part on the received second neurobehavioral profile and the received first set of testing-condition data; and

determining, with the computer, a comparison of the determined neurobehavioral status of the first population associated with the first set of testing conditions relative to the determined neurobehavioral status of the second population associated with the first set of testing conditions.